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Anal Precancerous Condition

MedGen UID:
231064
•Concept ID:
C1332275
•
Disease or Syndrome
Synonym: Anal Premalignant Condition

Professional guidelines

PubMed

Future Directions for Research on Anal Precancerous Lesion Treatment.
Albuquerque A
J Low Genit Tract Dis 2023 Oct 1;27(4):356-357. Epub 2023 Jul 19 doi: 10.1097/LGT.0000000000000768. PMID: 37729045
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article

Recent clinical studies

Etiology

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, Rosa-Cunha I, Arons A, Pugliese JC, Vena D, Sparano JA, Wilkin TJ, Bucher G, Stier EA, Tirado Gomez M, Flowers L, Barroso LF, Mitsuyasu RT, Lensing SY, Logan J, Aboulafia DM, Schouten JT, de la Ossa J, Levine R, Korman JD, Hagensee M, Atkinson TM, Einstein MH, Cracchiolo BM, Wiley D, Ellsworth GB, Brickman C, Berry-Lawhorn JM; ANCHOR Investigators Group
N Engl J Med 2022 Jun 16;386(24):2273-2282. doi: 10.1056/NEJMoa2201048. PMID: 35704479Free PMC Article
Anal cancer and precancerous lesions: a call for improvement.
Albuquerque A, Nathan M, Cappello C, Dinis-Ribeiro M
Lancet Gastroenterol Hepatol 2021 Apr;6(4):327-334. doi: 10.1016/S2468-1253(20)30304-6. PMID: 33714370
A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.
Clifford GM, Georges D, Shiels MS, Engels EA, Albuquerque A, Poynten IM, de Pokomandy A, Easson AM, Stier EA
Int J Cancer 2021 Jan 1;148(1):38-47. Epub 2020 Jul 29 doi: 10.1002/ijc.33185. PMID: 32621759Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article

Diagnosis

Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, Rosa-Cunha I, Arons A, Pugliese JC, Vena D, Sparano JA, Wilkin TJ, Bucher G, Stier EA, Tirado Gomez M, Flowers L, Barroso LF, Mitsuyasu RT, Lensing SY, Logan J, Aboulafia DM, Schouten JT, de la Ossa J, Levine R, Korman JD, Hagensee M, Atkinson TM, Einstein MH, Cracchiolo BM, Wiley D, Ellsworth GB, Brickman C, Berry-Lawhorn JM; ANCHOR Investigators Group
N Engl J Med 2022 Jun 16;386(24):2273-2282. doi: 10.1056/NEJMoa2201048. PMID: 35704479Free PMC Article
Anal cancer and precancerous lesions: a call for improvement.
Albuquerque A, Nathan M, Cappello C, Dinis-Ribeiro M
Lancet Gastroenterol Hepatol 2021 Apr;6(4):327-334. doi: 10.1016/S2468-1253(20)30304-6. PMID: 33714370
A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.
Clifford GM, Georges D, Shiels MS, Engels EA, Albuquerque A, Poynten IM, de Pokomandy A, Easson AM, Stier EA
Int J Cancer 2021 Jan 1;148(1):38-47. Epub 2020 Jul 29 doi: 10.1002/ijc.33185. PMID: 32621759Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
Pouch-ouch.
Maser EA, Present DH
Curr Opin Gastroenterol 2008 Jan;24(1):70-4. doi: 10.1097/MOG.0b013e3282f2dfa3. PMID: 18043236

Therapy

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, Rosa-Cunha I, Arons A, Pugliese JC, Vena D, Sparano JA, Wilkin TJ, Bucher G, Stier EA, Tirado Gomez M, Flowers L, Barroso LF, Mitsuyasu RT, Lensing SY, Logan J, Aboulafia DM, Schouten JT, de la Ossa J, Levine R, Korman JD, Hagensee M, Atkinson TM, Einstein MH, Cracchiolo BM, Wiley D, Ellsworth GB, Brickman C, Berry-Lawhorn JM; ANCHOR Investigators Group
N Engl J Med 2022 Jun 16;386(24):2273-2282. doi: 10.1056/NEJMoa2201048. PMID: 35704479Free PMC Article
A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.
Clifford GM, Georges D, Shiels MS, Engels EA, Albuquerque A, Poynten IM, de Pokomandy A, Easson AM, Stier EA
Int J Cancer 2021 Jan 1;148(1):38-47. Epub 2020 Jul 29 doi: 10.1002/ijc.33185. PMID: 32621759Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
Human Papillomavirus in Kidney Transplant Recipients.
Chin-Hong PV
Semin Nephrol 2016 Sep;36(5):397-404. doi: 10.1016/j.semnephrol.2016.05.016. PMID: 27772624Free PMC Article

Prognosis

Human papillomavirus vaccination and anal high-grade precancerous lesions and cancer-a real-world effectiveness study.
Baandrup L, Maltesen T, Dehlendorff C, Kjaer SK
J Natl Cancer Inst 2024 Feb 8;116(2):283-287. doi: 10.1093/jnci/djad189. PMID: 37718496
A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.
Clifford GM, Georges D, Shiels MS, Engels EA, Albuquerque A, Poynten IM, de Pokomandy A, Easson AM, Stier EA
Int J Cancer 2021 Jan 1;148(1):38-47. Epub 2020 Jul 29 doi: 10.1002/ijc.33185. PMID: 32621759Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236
Pouch-ouch.
Maser EA, Present DH
Curr Opin Gastroenterol 2008 Jan;24(1):70-4. doi: 10.1097/MOG.0b013e3282f2dfa3. PMID: 18043236

Clinical prediction guides

Human papillomavirus vaccination and anal high-grade precancerous lesions and cancer-a real-world effectiveness study.
Baandrup L, Maltesen T, Dehlendorff C, Kjaer SK
J Natl Cancer Inst 2024 Feb 8;116(2):283-287. doi: 10.1093/jnci/djad189. PMID: 37718496
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Anal cancer and precancerous lesions: a call for improvement.
Albuquerque A, Nathan M, Cappello C, Dinis-Ribeiro M
Lancet Gastroenterol Hepatol 2021 Apr;6(4):327-334. doi: 10.1016/S2468-1253(20)30304-6. PMID: 33714370
Anal Intraepithelial Neoplasia Screening With Anal Pap Tests: Follow-up and Corresponding Histology.
Geltzeiler CB, Son J, Carchman EH, Lawson EH, Harms BA, Striker R, Selvaggi S, Voils CI
J Surg Res 2019 Dec;244:117-121. Epub 2019 Jul 5 doi: 10.1016/j.jss.2019.06.029. PMID: 31284140
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
The increasing incidence of anal cancer: can it be explained by trends in risk groups?
van der Zee RP, Richel O, de Vries HJ, Prins JM
Neth J Med 2013 Oct;71(8):401-11. PMID: 24127500
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
HPV and precancerous lesions of anal canal in women: systematic review.
Castor Md, da Silva HJ, Gondim Martins DB, de Mello RJ
Int J Colorectal Dis 2012 Mar;27(3):271-6. Epub 2011 Aug 17 doi: 10.1007/s00384-011-1298-1. PMID: 21847546

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