U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast apocrine carcinoma in situ

MedGen UID:
231073
•Concept ID:
C1332315
•
Neoplastic Process
Synonyms: Apocrine Breast Carcinoma In Situ; apocrine breast carcinoma in situ; Apocrine Carcinoma In Situ of Breast; apocrine carcinoma in situ of breast; Apocrine Carcinoma In Situ of the Breast; apocrine carcinoma in situ of the breast; Breast Apocrine Carcinoma In Situ; breast apocrine carcinoma in situ
 
Monarch Initiative: MONDO:0004562

Definition

A ductal breast carcinoma in situ, characterized by the presence of neoplastic epithelial cells with apocrine differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast apocrine carcinoma in situ

Professional guidelines

PubMed

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Significance of rat mammary tumors for human risk assessment.
Russo J
Toxicol Pathol 2015 Feb;43(2):145-70. Epub 2014 May 28 doi: 10.1177/0192623314532036. PMID: 25714400Free PMC Article
Mammary ductoscopy in the current management of breast disease.
Tang SS, Twelves DJ, Isacke CM, Gui GP
Surg Endosc 2011 Jun;25(6):1712-22. Epub 2010 Dec 18 doi: 10.1007/s00464-010-1465-4. PMID: 21170661

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Mitigating overdiagnosis and overtreatment in breast cancer: what is the role of the pathologist?
Calhoun BC, Livasy CA
Arch Pathol Lab Med 2014 Nov;138(11):1428-31. Epub 2014 Mar 14 doi: 10.5858/arpa.2013-0763-ED. PMID: 24628451
An update on apocrine lesions of the breast.
O'Malley FP, Bane A
Histopathology 2008 Jan;52(1):3-10. doi: 10.1111/j.1365-2559.2007.02888.x. PMID: 18171412

Diagnosis

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303

Therapy

Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Intraductal fulvestrant for therapy of ERα-positive ductal carcinoma in situ of the breast: a preclinical study.
Wang G, Chen C, Pai P, Korangath P, Sun S, Merino VF, Yuan J, Li S, Nie G, Stearns V, Sukumar S
Carcinogenesis 2019 Jul 20;40(7):903-913. doi: 10.1093/carcin/bgz084. PMID: 31046118
Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers.
Vranic S, Feldman R, Gatalica Z
Bosn J Basic Med Sci 2017 Feb 21;17(1):9-11. doi: 10.17305/bjbms.2016.1811. PMID: 28027454Free PMC Article
Mammary ductoscopy in the current management of breast disease.
Tang SS, Twelves DJ, Isacke CM, Gui GP
Surg Endosc 2011 Jun;25(6):1712-22. Epub 2010 Dec 18 doi: 10.1007/s00464-010-1465-4. PMID: 21170661
Toward a physiological approach to breast cancer prevention.
Russo J, Russo IH
Cancer Epidemiol Biomarkers Prev 1994 Jun;3(4):353-64. PMID: 8061586

Prognosis

Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article

Clinical prediction guides

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Current issues in diagnostic breast pathology.
Walker RA, Hanby A, Pinder SE, Thomas J, Ellis IO; National Coordinating Committee for Breast Pathology Research Subgroup
J Clin Pathol 2012 Sep;65(9):771-85. Epub 2012 Jul 19 doi: 10.1136/jclinpath-2012-200733. PMID: 22813732
The "Rosen Triad": tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions.
Brandt SM, Young GQ, Hoda SA
Adv Anat Pathol 2008 May;15(3):140-6. doi: 10.1097/PAP.0b013e31816ff313. PMID: 18434766

Recent systematic reviews

Relationships of sex steroid hormone levels in benign and cancerous breast tissue and blood: A critical appraisal of current science.
Stanczyk FZ, Mathews BW, Sherman ME
Steroids 2015 Jul;99(Pt A):91-102. Epub 2014 Dec 30 doi: 10.1016/j.steroids.2014.12.011. PMID: 25554581
Non-mass-like lesions on breast ultrasonography: a systematic review.
Uematsu T
Breast Cancer 2012 Oct;19(4):295-301. Epub 2012 Mar 29 doi: 10.1007/s12282-012-0364-z. PMID: 22456924

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...