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Appendix leiomyoma

MedGen UID:
231077
•Concept ID:
C1332327
•
Neoplastic Process
Synonyms: Appendiceal Leiomyoma; appendiceal leiomyoma; Appendix Leiomyoma; appendix leiomyoma; Leiomyoma of appendix; Leiomyoma of Appendix; leiomyoma of appendix; Leiomyoma of the Appendix; leiomyoma of the appendix; leiomyoma of vermiform appendix; vermiform appendix leiomyoma
SNOMED CT: Leiomyoma of appendix (1196825006)
 
Monarch Initiative: MONDO:0003300

Definition

A well-circumscribed benign smooth muscle neoplasm arising from the appendix. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix leiomyoma

Professional guidelines

PubMed

Guideline No. 435: Minimally Invasive Surgery in Fertility Therapy.
Motan T, Antaki R, Han J, Elliott J, Cockwell H
J Obstet Gynaecol Can 2023 Apr;45(4):273-282.e2. doi: 10.1016/j.jogc.2023.03.004. PMID: 37149339
Laparoscopic treatment of chronic pelvic pain in 100 adult women.
Carter JE
J Am Assoc Gynecol Laparosc 1995 May;2(3):255-62. doi: 10.1016/s1074-3804(05)80105-7. PMID: 9050567

Recent clinical studies

Etiology

Guideline No. 435: Minimally Invasive Surgery in Fertility Therapy.
Motan T, Antaki R, Han J, Elliott J, Cockwell H
J Obstet Gynaecol Can 2023 Apr;45(4):273-282.e2. doi: 10.1016/j.jogc.2023.03.004. PMID: 37149339
A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial.
Middelkoop MA, Huirne JAF, van der Weide MCJ, Bosmans JE, Hehenkamp WJK; MYOMEX-2 TRIAL GROUP
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:63-69. Epub 2020 Oct 28 doi: 10.1016/j.ejogrb.2020.10.058. PMID: 33171419
Extracolonic tumors of the gastrointestinal tract detected incidentally at screening CT colonography.
Pickhardt PJ, Kim DH, Taylor AJ, Gopal DV, Weber SM, Heise CP
Dis Colon Rectum 2007 Jan;50(1):56-63. doi: 10.1007/s10350-006-0806-9. PMID: 17115333
Combined hysteroscopic and laparoscopic findings in patients with chronic pelvic pain.
Carter JE
J Am Assoc Gynecol Laparosc 1994 Nov;2(1):43-7. doi: 10.1016/s1074-3804(05)80830-8. PMID: 9050532
Tumors of the appendix.
Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

Diagnosis

Myometrial myxoidosis in a patient with systemic lupus erythematosus.
Alghamdi DA
Ann Saudi Med 2021 Mar-Apr;41(2):121-126. Epub 2021 Apr 1 doi: 10.5144/0256-4947.2021.121. PMID: 33818144Free PMC Article
Concurrent appendiceal and umbilical endometriosis: a case report and review of the literature.
Paramythiotis D, Stavrou G, Panidis S, Panagiotou D, Chatzopoulos K, Papadopoulos VN, Michalopoulos A
J Med Case Rep 2014 Jul 22;8:258. doi: 10.1186/1752-1947-8-258. PMID: 25052818Free PMC Article
Neurogenous hyperplasia in the oesophagus.
Kara T, Gurses I, Serinsoz E, Bozdogan Arpaci R, Ucbilek E, Polat A
Malays J Pathol 2013 Jun;35(1):99-102. PMID: 23817402
Tumors of the appendix and colon.
Hatch KF, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Davis GB, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):430-6. doi: 10.1007/s002689910068. PMID: 10706915
Leiomyoma of the appendix.
Powell JL, Fuerst JF, Tapia RA
South Med J 1980 Sep;73(9):1298-9. doi: 10.1097/00007611-198009000-00057. PMID: 7414395

Therapy

A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial.
Middelkoop MA, Huirne JAF, van der Weide MCJ, Bosmans JE, Hehenkamp WJK; MYOMEX-2 TRIAL GROUP
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:63-69. Epub 2020 Oct 28 doi: 10.1016/j.ejogrb.2020.10.058. PMID: 33171419
A unique presentation of superinfected pseudomyxoma peritonei secondary to a low-grade appendiceal mucinous neoplasm.
Sullivan BJ, Bolton N, Sarpel U, Magge D
World J Surg Oncol 2019 Feb 18;17(1):34. doi: 10.1186/s12957-019-1578-8. PMID: 30777068Free PMC Article

Prognosis

Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy.
Sohn VY, Arthurs ZM, Martin MJ, Sebesta JA, Branch JB, Champeaux AL
Surg Obes Relat Dis 2008 Sep-Oct;4(5):608-11. Epub 2008 Jun 30 doi: 10.1016/j.soard.2008.01.015. PMID: 18586563
Gastrointestinal stromal tumors: update.
Xie XY, Carter N, Darwin PE, Drachenberg CB
Arkh Patol 2004 Mar-Apr;66(2):36-40. PMID: 15154382
Tumors of the appendix and colon.
Hatch KF, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Davis GB, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):430-6. doi: 10.1007/s002689910068. PMID: 10706915
Laparoscopic treatment of chronic pelvic pain in 100 adult women.
Carter JE
J Am Assoc Gynecol Laparosc 1995 May;2(3):255-62. doi: 10.1016/s1074-3804(05)80105-7. PMID: 9050567
Mucinous carcinoid and endometriosis in an inside-out appendix.
Rodriguez MA, Wasdahl WA
Am J Gastroenterol 1978 Feb;69(2):199-202. PMID: 665643

Clinical prediction guides

A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial.
Middelkoop MA, Huirne JAF, van der Weide MCJ, Bosmans JE, Hehenkamp WJK; MYOMEX-2 TRIAL GROUP
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:63-69. Epub 2020 Oct 28 doi: 10.1016/j.ejogrb.2020.10.058. PMID: 33171419
Neurogenous hyperplasia in the oesophagus.
Kara T, Gurses I, Serinsoz E, Bozdogan Arpaci R, Ucbilek E, Polat A
Malays J Pathol 2013 Jun;35(1):99-102. PMID: 23817402
Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.
Katsetos CD, Jami MM, Krishna L, Jackson R, Patchefsky AS, Cooper HS
Arch Pathol Lab Med 1994 Jun;118(6):633-9. PMID: 8204010
Tumors of the appendix.
Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

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