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Atrial Septum Lipomatous Hypertrophy

MedGen UID:
231085
•Concept ID:
C1332344
•
Disease or Syndrome
Synonyms: Interatrial Septum Lipomatous Hypertrophy; Massive Fatty Deposits of Atrial Septum; Massive Fatty Deposits of the Atrial Septum

Definition

A condition in which deposits of fat accumulate within the interatrial septum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtrial Septum Lipomatous Hypertrophy

Professional guidelines

PubMed

Intracardiac echocardiography (9 MHz) in humans: methods, imaging views and clinical utility.
Ren JF, Schwartzman D, Callans DJ, Brode SE, Gottlieb CD, Marchlinski FE
Ultrasound Med Biol 1999 Sep;25(7):1077-86. doi: 10.1016/s0301-5629(99)00064-2. PMID: 10574340

Recent clinical studies

Etiology

Lipomatous hypertrophy of the atrial septum - a benign heart anomaly causing unexpected surgical problems: a case report.
Bielicki G, Lukaszewski M, Kosiorowska K, Jakubaszko J, Nowicki R, Jasinski M
BMC Cardiovasc Disord 2018 Jul 28;18(1):152. doi: 10.1186/s12872-018-0892-3. PMID: 30055568Free PMC Article
A rare case of gint lipomatous hypertrophy of the atrial septum.
Carino D, Agostinelli A, Ricci M, Romano G, Nicolini F, Gherli T
Acta Biomed 2018 Mar 27;89(1):114-116. doi: 10.23750/abm.v89i1.5224. PMID: 29633754Free PMC Article
Lipomatous Atrial Septal Hypertrophy: A Review of Its Anatomy, Pathophysiology, Multimodality Imaging, and Relevance to Percutaneous Interventions.
Laura DM, Donnino R, Kim EE, Benenstein R, Freedberg RS, Saric M
J Am Soc Echocardiogr 2016 Aug;29(8):717-723. Epub 2016 Jun 7 doi: 10.1016/j.echo.2016.04.014. PMID: 27288088
Lipomatous hypertrophy of the interatrial septum in ECG-gated multislice computed tomography of the heart.
Czekajska-Chehab E, Tomaszewska M, Olchowik G, Tomaszewski M, Adamczyk P, Drop A
Med Sci Monit 2012 Jul;18(7):MT54-9. doi: 10.12659/msm.883197. PMID: 22739745Free PMC Article
Lipomatous hypertrophy of the atrial septum presenting as a right atrial mass.
Burke AP, Litovsky S, Virmani R
Am J Surg Pathol 1996 Jun;20(6):678-85. doi: 10.1097/00000478-199606000-00004. PMID: 8651346

Diagnosis

Lipomatous hypertrophy of the interatrial septum is a pathologic, not an anatomic diagnosis.
An KR, Butany J, Cusimano RJ
J Card Surg 2020 May;35(5):1132-1134. Epub 2020 Apr 1 doi: 10.1111/jocs.14528. PMID: 32237173
Lipomatous Atrial Septal Hypertrophy: A Review of Its Anatomy, Pathophysiology, Multimodality Imaging, and Relevance to Percutaneous Interventions.
Laura DM, Donnino R, Kim EE, Benenstein R, Freedberg RS, Saric M
J Am Soc Echocardiogr 2016 Aug;29(8):717-723. Epub 2016 Jun 7 doi: 10.1016/j.echo.2016.04.014. PMID: 27288088
The right atrium: gateway to the heart--anatomic and pathologic imaging findings.
Malik SB, Kwan D, Shah AB, Hsu JY
Radiographics 2015 Jan-Feb;35(1):14-31. doi: 10.1148/rg.351130010. PMID: 25590385
Cardiovascular pseudoneoplasms.
Miller DV, Tazelaar HD
Arch Pathol Lab Med 2010 Mar;134(3):362-8. doi: 10.5858/134.3.362. PMID: 20196664
Lipomatous hypertrophy of the interatrial septum: a pathological and clinical approach.
Xanthos T, Giannakopoulos N, Papadimitriou L
Int J Cardiol 2007 Sep 14;121(1):4-8. Epub 2007 Feb 12 doi: 10.1016/j.ijcard.2006.11.150. PMID: 17292988

Therapy

Lipomatous hypertrophy of the atrial septum - a benign heart anomaly causing unexpected surgical problems: a case report.
Bielicki G, Lukaszewski M, Kosiorowska K, Jakubaszko J, Nowicki R, Jasinski M
BMC Cardiovasc Disord 2018 Jul 28;18(1):152. doi: 10.1186/s12872-018-0892-3. PMID: 30055568Free PMC Article
Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction.
Dudley MH, Fleming SW, Garg U, Edwards JM
J Forensic Sci 2011 Sep;56(5):1376-9. Epub 2011 Jul 25 doi: 10.1111/j.1556-4029.2011.01829.x. PMID: 21790593
Orthodeoxia platypnea syndrome in a patient with lipomatous hypertrophy of the interatrial septum due to long-term steroid use.
Bokhari SSI, Willens HJ, Lowery MH, Wanner A, deMarchena E
Chest 2011 Feb;139(2):443-445. doi: 10.1378/chest.10-0874. PMID: 21285060
Analysis of the interatrial septum by transesophageal echocardiography in adult cardiac surgical patients: anatomic variants and correlation with patent foramen ovale.
Augoustides JG, Weiss SJ, Ochroch AE, Weiner J, Mancini J, Savino JS, Cheung AT
J Cardiothorac Vasc Anesth 2005 Apr;19(2):146-9. doi: 10.1053/j.jvca.2005.01.021. PMID: 15868518
Lipomatous hypertrophy of the cardiac interatrial septum: an unusual complication in long-term home parenteral nutrition in adult patients.
Beau P, Michel P, Coisne D, Morichau-Beauchant M
JPEN J Parenter Enteral Nutr 1991 Nov-Dec;15(6):659-62. doi: 10.1177/0148607191015006659. PMID: 1837317

Prognosis

Lipomatous hypertrophy of the atrial septum - a benign heart anomaly causing unexpected surgical problems: a case report.
Bielicki G, Lukaszewski M, Kosiorowska K, Jakubaszko J, Nowicki R, Jasinski M
BMC Cardiovasc Disord 2018 Jul 28;18(1):152. doi: 10.1186/s12872-018-0892-3. PMID: 30055568Free PMC Article
Lipomatous Hypertrophy of the Interatrial Septum.
Alpert L, Antic T
Int J Surg Pathol 2017 Oct;25(7):611-612. Epub 2017 May 9 doi: 10.1177/1066896917708398. PMID: 28485184
Lipomatous hypertrophy of the intraatrial septum resulting in right atrial inflow obstruction and atrial flutter.
Dickerson JA, Smith M, Kalbfleisch S, Firstenberg MS
Ann Thorac Surg 2010 May;89(5):1647-9. doi: 10.1016/j.athoracsur.2009.10.001. PMID: 20417803
Lipomatous hypertrophy of the interatrial septum: a pathological and clinical approach.
Xanthos T, Giannakopoulos N, Papadimitriou L
Int J Cardiol 2007 Sep 14;121(1):4-8. Epub 2007 Feb 12 doi: 10.1016/j.ijcard.2006.11.150. PMID: 17292988
Lipomatous hypertrophy of the interatrial septum: a prospective study of incidence, imaging findings, and clinical symptoms.
Heyer CM, Kagel T, Lemburg SP, Bauer TT, Nicolas V
Chest 2003 Dec;124(6):2068-73. doi: 10.1378/chest.124.6.2068. PMID: 14665481

Clinical prediction guides

18F-FDG PET/CT helps rule out malignancy in lipomatous hypertrophy of the interatrial septum with atypical MRI manifestations, to avoid unnecessary surgical treatment.
Du Y, Li C, Chen S, Zhong Y, Yu S, Wang G
Int J Cardiovasc Imaging 2022 Sep;38(9):2089-2092. Epub 2022 May 14 doi: 10.1007/s10554-022-02632-w. PMID: 37726612
Lipomatous hypertrophy of the atrial septum - a benign heart anomaly causing unexpected surgical problems: a case report.
Bielicki G, Lukaszewski M, Kosiorowska K, Jakubaszko J, Nowicki R, Jasinski M
BMC Cardiovasc Disord 2018 Jul 28;18(1):152. doi: 10.1186/s12872-018-0892-3. PMID: 30055568Free PMC Article
Lipomatous hypertrophy of the interatrial septum in ECG-gated multislice computed tomography of the heart.
Czekajska-Chehab E, Tomaszewska M, Olchowik G, Tomaszewski M, Adamczyk P, Drop A
Med Sci Monit 2012 Jul;18(7):MT54-9. doi: 10.12659/msm.883197. PMID: 22739745Free PMC Article
Cardiovascular pseudoneoplasms.
Miller DV, Tazelaar HD
Arch Pathol Lab Med 2010 Mar;134(3):362-8. doi: 10.5858/134.3.362. PMID: 20196664
Intracardiac echocardiography (9 MHz) in humans: methods, imaging views and clinical utility.
Ren JF, Schwartzman D, Callans DJ, Brode SE, Gottlieb CD, Marchlinski FE
Ultrasound Med Biol 1999 Sep;25(7):1077-86. doi: 10.1016/s0301-5629(99)00064-2. PMID: 10574340

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