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AIDS-Related Anal Carcinoma

MedGen UID:
231324
•Concept ID:
C1332038
•
Neoplastic Process
Synonym: AIDS-Related Anal Cancer

Definition

A carcinoma arising from the anus and occurring in HIV-positive patients. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Sexually transmitted human papillomavirus is detected in the majority of the cases. [from NCI]

Professional guidelines

PubMed

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Recent clinical studies

Etiology

Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Non-AIDS-defining cancers and HIV infection.
Lim ST, Levine AM
Curr HIV/AIDS Rep 2005 Aug;2(3):146-53. doi: 10.1007/s11904-005-0008-4. PMID: 16091262
Pathogenesis of non-AIDS-defining cancers: a review.
Wistuba II, Behrens C, Gazdar AF
AIDS Patient Care STDS 1999 Jul;13(7):415-26. doi: 10.1089/apc.1999.13.415. PMID: 10870595
The epidemiology of AIDS--related neoplasms.
Biggar RJ, Rabkin CS
Hematol Oncol Clin North Am 1996 Oct;10(5):997-1010. doi: 10.1016/s0889-8588(05)70380-4. PMID: 8880192
Epidemiology of AIDS-related malignancies.
Rabkin CS
Curr Opin Oncol 1994 Sep;6(5):492-6. doi: 10.1097/00001622-199409000-00008. PMID: 7827152

Diagnosis

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Therapy

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Biology of HPV in HIV infection.
Palefsky J
Adv Dent Res 2006 Apr 1;19(1):99-105. doi: 10.1177/154407370601900120. PMID: 16672559
Non-AIDS-defining cancers and HIV infection.
Lim ST, Levine AM
Curr HIV/AIDS Rep 2005 Aug;2(3):146-53. doi: 10.1007/s11904-005-0008-4. PMID: 16091262
AIDS-related tumors: integrating antiviral and anticancer therapy.
Tirelli U, Bernardi D, Spina M, Vaccher E
Crit Rev Oncol Hematol 2002 Mar;41(3):299-315. doi: 10.1016/s1040-8428(01)00165-2. PMID: 11880206

Prognosis

Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Non-AIDS-defining cancers and HIV infection.
Lim ST, Levine AM
Curr HIV/AIDS Rep 2005 Aug;2(3):146-53. doi: 10.1007/s11904-005-0008-4. PMID: 16091262
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Pathogenesis of non-AIDS-defining cancers: a review.
Wistuba II, Behrens C, Gazdar AF
AIDS Patient Care STDS 1999 Jul;13(7):415-26. doi: 10.1089/apc.1999.13.415. PMID: 10870595

Clinical prediction guides

Non-AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.
Zucchetto A, Virdone S, Taborelli M, Grande E, Camoni L, Pappagallo M, Regine V, Grippo F, Polesel J, Dal Maso L, Suligoi B, Frova L, Serraino D
J Acquir Immune Defic Syndr 2016 Oct 1;73(2):190-6. doi: 10.1097/QAI.0000000000001033. PMID: 27116048
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA
Int J STD AIDS 2007 Feb;18(2):77-80. doi: 10.1258/095646207779949772. PMID: 17331275
Non-AIDS-defining cancers and HIV infection.
Lim ST, Levine AM
Curr HIV/AIDS Rep 2005 Aug;2(3):146-53. doi: 10.1007/s11904-005-0008-4. PMID: 16091262
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Acquired immunodeficiency syndrome-associated cancers in Sub-Saharan Africa.
Thomas JO
Semin Oncol 2001 Apr;28(2):198-206. doi: 10.1016/s0093-7754(01)90092-2. PMID: 11301383

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