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Abstinence Syndrome

MedGen UID:
231348
•Concept ID:
C1332133
•
Disease or Syndrome

Definition

A syndrome which occurs following withdrawal of an abused substance. Clinical signs vary depending on the substance that was abused and may include irritability, trembling and vomiting. The clinical course depends on the ability to manage the withdrawal symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbstinence Syndrome

Professional guidelines

PubMed

Interventions for the Treatment of Neonatal Abstinence Syndrome.
Cook CE, Fantasia HC
Nurs Womens Health 2019 Aug;23(4):357-365. Epub 2019 Jun 25 doi: 10.1016/j.nwh.2019.05.006. PMID: 31251931
Medication Use and Pain Management in Pregnancy: A Critical Review.
Black E, Khor KE, Kennedy D, Chutatape A, Sharma S, Vancaillie T, Demirkol A
Pain Pract 2019 Nov;19(8):875-899. Epub 2019 Aug 13 doi: 10.1111/papr.12814. PMID: 31242344
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184

Recent clinical studies

Etiology

Eat, Sleep, Console Approach: A Family-Centered Model for the Treatment of Neonatal Abstinence Syndrome.
Grisham LM, Stephen MM, Coykendall MR, Kane MF, Maurer JA, Bader MY
Adv Neonatal Care 2019 Apr;19(2):138-144. doi: 10.1097/ANC.0000000000000581. PMID: 30855311
After NAS.
Oei JL
Semin Fetal Neonatal Med 2019 Apr;24(2):161-165. Epub 2019 Feb 15 doi: 10.1016/j.siny.2019.01.012. PMID: 30797731
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome.
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK
Hosp Pediatr 2018 Jan;8(1):1-6. doi: 10.1542/hpeds.2017-0128. PMID: 29263121
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299
Prenatal substance abuse: short- and long-term effects on the exposed fetus.
Behnke M, Smith VC; Committee on Substance Abuse; Committee on Fetus and Newborn
Pediatrics 2013 Mar;131(3):e1009-24. Epub 2013 Feb 25 doi: 10.1542/peds.2012-3931. PMID: 23439891Free PMC Article

Diagnosis

The Eat, Sleep, Console Method: A Literature Review.
Nicholson S, Waskosky A
Neonatal Netw 2022 Nov 11;41(6):333-340. doi: 10.1891/NN-2021-0003. PMID: 36446434
Neonatal Opioid Withdrawal Syndrome.
Patrick SW, Barfield WD, Poindexter BB; COMMITTEE ON FETUS AND NEWBORN, COMMITTEE ON SUBSTANCE USE AND PREVENTION
Pediatrics 2020 Nov;146(5) doi: 10.1542/peds.2020-029074. PMID: 33106341
Neonatal Abstinence Syndrome.
Jansson LM, Patrick SW
Pediatr Clin North Am 2019 Apr;66(2):353-367. doi: 10.1016/j.pcl.2018.12.006. PMID: 30819342Free PMC Article
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299

Therapy

Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
MacMillan KDL
Clin Perinatol 2019 Dec;46(4):817-832. Epub 2019 Aug 14 doi: 10.1016/j.clp.2019.08.012. PMID: 31653310
Neonatal Abstinence Syndrome.
Jansson LM, Patrick SW
Pediatr Clin North Am 2019 Apr;66(2):353-367. doi: 10.1016/j.pcl.2018.12.006. PMID: 30819342Free PMC Article
Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS).
Mangat AK, Schmölzer GM, Kraft WK
Semin Fetal Neonatal Med 2019 Apr;24(2):133-141. Epub 2019 Feb 5 doi: 10.1016/j.siny.2019.01.009. PMID: 30745219Free PMC Article
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299

Prognosis

Medication Use and Pain Management in Pregnancy: A Critical Review.
Black E, Khor KE, Kennedy D, Chutatape A, Sharma S, Vancaillie T, Demirkol A
Pain Pract 2019 Nov;19(8):875-899. Epub 2019 Aug 13 doi: 10.1111/papr.12814. PMID: 31242344
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome.
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK
Hosp Pediatr 2018 Jan;8(1):1-6. doi: 10.1542/hpeds.2017-0128. PMID: 29263121
Neonatal Abstinence Syndrome.
McQueen K, Murphy-Oikonen J
N Engl J Med 2016 Dec 22;375(25):2468-2479. doi: 10.1056/NEJMra1600879. PMID: 28002715
Nicotine withdrawal.
McLaughlin I, Dani JA, De Biasi M
Curr Top Behav Neurosci 2015;24:99-123. doi: 10.1007/978-3-319-13482-6_4. PMID: 25638335Free PMC Article

Clinical prediction guides

The Eat, Sleep, Console Method: A Literature Review.
Nicholson S, Waskosky A
Neonatal Netw 2022 Nov 11;41(6):333-340. doi: 10.1891/NN-2021-0003. PMID: 36446434
Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials.
Ghazanfarpour M, Najafi MN, Roozbeh N, Mashhadi ME, Keramat-Roudi A, Mégarbane B, Tsatsakis A, Moghaddam MMM, Rezaee R
Daru 2019 Jun;27(1):423-431. Epub 2019 May 15 doi: 10.1007/s40199-019-00266-3. PMID: 31093953Free PMC Article
Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS).
Mangat AK, Schmölzer GM, Kraft WK
Semin Fetal Neonatal Med 2019 Apr;24(2):133-141. Epub 2019 Feb 5 doi: 10.1016/j.siny.2019.01.009. PMID: 30745219Free PMC Article
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Neonatal abstinence syndrome.
Kocherlakota P
Pediatrics 2014 Aug;134(2):e547-61. doi: 10.1542/peds.2013-3524. PMID: 25070299

Recent systematic reviews

Neonatal abstinence syndrome: a systematic review of current databases and registries.
Zakerabasali S, Safdari R, Kadivar M, Rostam Niakan Kalhori S, Mokhtaran M, Karbasi Z, Sayarifard A, Abhari S
J Matern Fetal Neonatal Med 2021 Mar;34(6):979-992. Epub 2019 May 27 doi: 10.1080/14767058.2019.1618827. PMID: 31092074
Non-pharmacological care for opioid withdrawal in newborns.
Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423Free PMC Article
Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials.
Ghazanfarpour M, Najafi MN, Roozbeh N, Mashhadi ME, Keramat-Roudi A, Mégarbane B, Tsatsakis A, Moghaddam MMM, Rezaee R
Daru 2019 Jun;27(1):423-431. Epub 2019 May 15 doi: 10.1007/s40199-019-00266-3. PMID: 31093953Free PMC Article
Role of Clonidine in Neonatal Abstinence Syndrome: A Systematic Review.
Streetz VN, Gildon BL, Thompson DF
Ann Pharmacother 2016 Apr;50(4):301-10. Epub 2016 Jan 18 doi: 10.1177/1060028015626438. PMID: 26783353
Swaddling: a systematic review.
van Sleuwen BE, Engelberts AC, Boere-Boonekamp MM, Kuis W, Schulpen TW, L'Hoir MP
Pediatrics 2007 Oct;120(4):e1097-106. doi: 10.1542/peds.2006-2083. PMID: 17908730

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