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Adrenal medullary hyperplasia

MedGen UID:
231356
•Concept ID:
C1332177
•
Pathologic Function
Synonyms: adrenal medulla hyperplasia; Adrenal Medullary Hyperplasia; adrenal medullary hyperplasia
 
Monarch Initiative: MONDO:0006077

Definition

A hyperplasia that involves the adrenal medulla. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal medullary hyperplasia

Professional guidelines

PubMed

Genotype-Phenotype Correlation in Indian Patients with MEN2-Associated Pheochromocytoma and Comparison of Clinico-Pathological Attributes with Apparently Sporadic Adrenal Pheochromocytoma.
Rajan S, Zaidi G, Agarwal G, Mishra A, Agarwal A, Mishra SK, Bhatia E
World J Surg 2016 Mar;40(3):690-6. doi: 10.1007/s00268-015-3255-6. PMID: 26438242
Dilemmas in the early diagnosis and treatment of multiple endocrine adenomatosis, type II.
Freier DT, Thompson NW, Sisson JC, Nishiyama RH, Freitas JE
Surgery 1977 Sep;82(3):407-13. PMID: 18807

Recent clinical studies

Etiology

Adrenal medullary hyperplasia mimicking pheochromocytoma.
Montebello A, Ceci MA, Vella S
BMJ Case Rep 2020 Sep 22;13(9) doi: 10.1136/bcr-2020-236209. PMID: 32963042Free PMC Article
Laparoscopic adrenalectomy for nonfamilial adrenal medullary hyperplasia.
Marín MR, Arenas MF, Valverde FM, Garaulet ET, Maderuelo MM, Avilés AM, Quirante FP, Blázquez AA
JSLS 2013 Jul-Sep;17(3):433-9. doi: 10.4293/108680813X13693422521476. PMID: 24018082Free PMC Article
Treatment of bilateral pheochromocytoma and adrenal medullary hyperplasia.
Jansson S, Khorram-Manesh A, Nilsson O, Kölby L, Tisell LE, Wängberg B, Ahlman H
Ann N Y Acad Sci 2006 Aug;1073:429-35. doi: 10.1196/annals.1353.046. PMID: 17102111
Weight and shape of the human adrenal medulla in various age groups.
Kreiner E
Virchows Arch A Pathol Anat Histol 1982;397(1):7-15. doi: 10.1007/BF00430889. PMID: 7147700
Adrenal medullary hyperplasia. A morphometric analysis in patients with familial medullary thyroid carcinoma.
DeLellis RA, Wolfe HJ, Gagel RF, Feldman ZT, Miller HH, Gang DL, Reichlin S
Am J Pathol 1976 Apr;83(1):177-96. PMID: 1275056Free PMC Article

Diagnosis

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article
Adrenal Medullary Hyperplasia: An Under the Radar Cause of Endocrine Hypertension.
Rivas Mejia AM, Cameselle-Teijeiro JM, Thavaraputta S, Lado-Abeal J
Am J Med Sci 2022 Jan;363(1):64-68. Epub 2020 Jul 3 doi: 10.1016/j.amjms.2020.06.031. PMID: 32732076
Adrenal medullary hyperplasia mimicking pheochromocytoma.
Montebello A, Ceci MA, Vella S
BMJ Case Rep 2020 Sep 22;13(9) doi: 10.1136/bcr-2020-236209. PMID: 32963042Free PMC Article
Adrenal medullary hyperplasia with coexistent cerebral angiomas.
Gupta L, Bhatt AS, Mallya V, Khurana N, Lal P
Indian J Pathol Microbiol 2018 Oct-Dec;61(4):587-589. doi: 10.4103/IJPM.IJPM_707_17. PMID: 30303158
Adrenal medullary hyperplasia is a precursor lesion for pheochromocytoma in MEN2 syndrome.
Korpershoek E, Petri BJ, Post E, van Eijck CH, Oldenburg RA, Belt EJ, de Herder WW, de Krijger RR, Dinjens WN
Neoplasia 2014 Oct;16(10):868-73. Epub 2014 Oct 23 doi: 10.1016/j.neo.2014.09.002. PMID: 25379023Free PMC Article

Therapy

Adrenal medullary hyperplasia mimicking pheochromocytoma.
Montebello A, Ceci MA, Vella S
BMJ Case Rep 2020 Sep 22;13(9) doi: 10.1136/bcr-2020-236209. PMID: 32963042Free PMC Article
[11C]metahydroxyephedrine and [18F]fluorodeoxyglucose positron emission tomography improve clinical decision making in suspected pheochromocytoma.
Mann GN, Link JM, Pham P, Pickett CA, Byrd DR, Kinahan PE, Krohn KA, Mankoff DA
Ann Surg Oncol 2006 Feb;13(2):187-97. Epub 2006 Jan 19 doi: 10.1245/ASO.2006.04.022. PMID: 16418883

Prognosis

Frequency of Cushing's syndrome due to ACTH-secreting adrenal medullary lesions: a retrospective study over 10 years from a single center.
Falhammar H, Calissendorff J, Höybye C
Endocrine 2017 Jan;55(1):296-302. Epub 2016 Oct 3 doi: 10.1007/s12020-016-1127-y. PMID: 27699708Free PMC Article
Sporadic bilateral adrenal medullary hyperplasia: apparent false positive MIBG scan and expected MRI findings.
Yung BC, Loke TK, Tse TW, Tsang MW, Chan JC
Eur J Radiol 2000 Oct;36(1):28-31. doi: 10.1016/s0720-048x(99)00166-7. PMID: 10996755
Mutation of RET codon 768 is associated with the FMTC phenotype.
Boccia LM, Green JS, Joyce C, Eng C, Taylor SA, Mulligan LM
Clin Genet 1997 Feb;51(2):81-5. doi: 10.1111/j.1399-0004.1997.tb02424.x. PMID: 9111992
Screening for adrenal medullary disease in patients with medullary thyroid carcinoma.
Bonnin F, Schlumberger M, Gardet P, Tenenbaum F, Lumbroso J, Leclere J, Comoy E, Megnigbeto A, Travagli JP, Parmentier C
J Endocrinol Invest 1994 Apr;17(4):253-7. doi: 10.1007/BF03348970. PMID: 7930376
Spontaneous proliferative lesions of the adrenal medulla in aging Long-Evans rats. Comparison to PC12 cells, small granule-containing cells, and human adrenal medullary hyperplasia.
Tischler AS, DeLellis RA, Perlman RL, Allen JM, Costopoulos D, Lee YC, Nunnemacher G, Wolfe HJ, Bloom SR
Lab Invest 1985 Oct;53(4):486-98. PMID: 2864475

Clinical prediction guides

Clinical identification of expressed proteins in adrenal medullary hyperplasia detected with hypertension.
Ma H, Wang K, Lai B, Zhang X, Lv Y, Li R
Front Endocrinol (Lausanne) 2022;13:1014366. Epub 2022 Dec 13 doi: 10.3389/fendo.2022.1014366. PMID: 36583008Free PMC Article
Bilateral adrenal uptake of (123)I MIBG scintigraphy with mild catecholamine elevation, the diagnostic dilemma, and its characteristics.
Inaba Y, Yamamoto M, Urai S, Suzuki M, Nishikage S, Kanzawa M, Aoyama Y, Kanda T, Shigemura K, Bando H, Iguchi G, Nakamura Y, Fujisawa M, Imagawa A, Fukuoka H, Ogawa W
Sci Rep 2022 Jun 3;12(1):9276. doi: 10.1038/s41598-022-13132-1. PMID: 35660748Free PMC Article
Ret protein expression in adrenal medullary hyperplasia and pheochromocytoma.
Powers JF, Brachold JM, Tischler AS
Endocr Pathol 2003 Winter;14(4):351-61. doi: 10.1385/ep:14:4:351. PMID: 14739491
Sugar alcohols as bulk sweeteners.
Dills WL Jr
Annu Rev Nutr 1989;9:161-86. doi: 10.1146/annurev.nu.09.070189.001113. PMID: 2669868
Enzootic and epizootic adrenal medullary proliferative disease of rats: influence of dietary factors which affect calcium absorption.
Roe FJ, Bär A
Hum Toxicol 1985 Jan;4(1):27-52. doi: 10.1177/096032718500400104. PMID: 3988303

Recent systematic reviews

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article

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