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Anaplastic Kidney Wilms Tumor

MedGen UID:
231375
•Concept ID:
C1332289
•
Neoplastic Process
Synonyms: Anaplastic Renal Wilm's Tumor; Anaplastic Renal Wilms Tumor; Anaplastic Renal Wilms' Tumor

Definition

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia. Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia. When anaplasia is diffuse, it is associated with an unfavorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Kidney Wilms Tumor

Professional guidelines

PubMed

Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2:e30342. doi: 10.1002/pbc.30342. PMID: 37096797
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101

Recent clinical studies

Etiology

Surgery for the complex Wilms tumour.
Cox S, Büyükünal C, Millar AJW
Pediatr Surg Int 2020 Feb;36(2):113-127. Epub 2019 Nov 7 doi: 10.1007/s00383-019-04596-w. PMID: 31701302
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties.
Vujanić GM, Schiavo Lena M, Sebire NJ
Virchows Arch 2019 Feb;474(2):227-234. Epub 2018 Dec 4 doi: 10.1007/s00428-018-2500-4. PMID: 30515564
Overexpressed oncogenic tumor-self antigens.
Bright RK, Bright JD, Byrne JA
Hum Vaccin Immunother 2014;10(11):3297-305. doi: 10.4161/hv.29475. PMID: 25483660Free PMC Article
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644
Wilms' tumor: status report, 1990. By the National Wilms' Tumor Study Committee.
J Clin Oncol 1991 May;9(5):877-87. doi: 10.1200/JCO.1991.9.5.877. PMID: 1849987

Diagnosis

Surgery for the complex Wilms tumour.
Cox S, Büyükünal C, Millar AJW
Pediatr Surg Int 2020 Feb;36(2):113-127. Epub 2019 Nov 7 doi: 10.1007/s00383-019-04596-w. PMID: 31701302
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties.
Vujanić GM, Schiavo Lena M, Sebire NJ
Virchows Arch 2019 Feb;474(2):227-234. Epub 2018 Dec 4 doi: 10.1007/s00428-018-2500-4. PMID: 30515564
Management of bilateral Wilms tumours.
Millar AJW, Cox S, Davidson A
Pediatr Surg Int 2017 Jul;33(7):737-745. Epub 2017 May 17 doi: 10.1007/s00383-017-4091-6. PMID: 28516188
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Therapy

Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children's Oncology Group Study AREN0534.
Ehrlich PF, Tornwall B, Chintagumpala MM, Chi YY, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Fernandez CV, Dome JS
Ann Surg Oncol 2022 May;29(5):3252-3261. Epub 2022 Jan 24 doi: 10.1245/s10434-021-11266-6. PMID: 35072864Free PMC Article
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101
Current and emerging chemotherapy treatment strategies for Wilms tumor in North America.
Gratias EJ, Dome JS
Paediatr Drugs 2008;10(2):115-24. doi: 10.2165/00148581-200810020-00006. PMID: 18345721
Wilms tumour: prognostic factors, staging, therapy and late effects.
Kaste SC, Dome JS, Babyn PS, Graf NM, Grundy P, Godzinski J, Levitt GA, Jenkinson H
Pediatr Radiol 2008 Jan;38(1):2-17. Epub 2007 Nov 17 doi: 10.1007/s00247-007-0687-7. PMID: 18026723
Preoperative therapy for intracaval and atrial extension of Wilms tumor.
Ritchey ML, Kelalis PP, Haase GM, Shochat SJ, Green DM, D'Angio G
Cancer 1993 Jun 15;71(12):4104-10. doi: 10.1002/1097-0142(19930615)71:12<4104::aid-cncr2820711249>3.0.co;2-7. PMID: 8389661

Prognosis

Surgery for the complex Wilms tumour.
Cox S, Büyükünal C, Millar AJW
Pediatr Surg Int 2020 Feb;36(2):113-127. Epub 2019 Nov 7 doi: 10.1007/s00383-019-04596-w. PMID: 31701302
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties.
Vujanić GM, Schiavo Lena M, Sebire NJ
Virchows Arch 2019 Feb;474(2):227-234. Epub 2018 Dec 4 doi: 10.1007/s00428-018-2500-4. PMID: 30515564
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
The roles of microRNAs in Wilms' tumors.
Yu X, Li Z, Chan MT, Wu WK
Tumour Biol 2016 Feb;37(2):1445-50. Epub 2015 Dec 3 doi: 10.1007/s13277-015-4514-8. PMID: 26634744

Clinical prediction guides

Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children's Oncology Group Study AREN0534.
Ehrlich PF, Tornwall B, Chintagumpala MM, Chi YY, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Fernandez CV, Dome JS
Ann Surg Oncol 2022 May;29(5):3252-3261. Epub 2022 Jan 24 doi: 10.1245/s10434-021-11266-6. PMID: 35072864Free PMC Article
Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.
Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C
Pediatr Blood Cancer 2022 Feb;69(2):e29401. Epub 2021 Oct 24 doi: 10.1002/pbc.29401. PMID: 34693628Free PMC Article
Immune expression in children with Wilms tumor: a pilot study.
Holl EK, Routh JC, Johnston AW, Frazier V, Rice HE, Tracy ET, Nair SK
J Pediatr Urol 2019 Oct;15(5):441.e1-441.e8. Epub 2019 Mar 20 doi: 10.1016/j.jpurol.2019.03.011. PMID: 30981637
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
B7-H1 expression in Wilms tumor: correlation with tumor biology and disease recurrence.
Routh JC, Ashley RA, Sebo TJ, Lohse CM, Husmann DA, Kramer SA, Kwon ED
J Urol 2008 May;179(5):1954-9; discussion 1959-60. Epub 2008 Mar 20 doi: 10.1016/j.juro.2008.01.056. PMID: 18355839Free PMC Article

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