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Anaplastic Kidney Wilms Tumor

MedGen UID:
231375
•Concept ID:
C1332289
•
Neoplastic Process
Synonyms: Anaplastic Renal Wilm's Tumor; Anaplastic Renal Wilms Tumor; Anaplastic Renal Wilms' Tumor

Definition

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia. Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia. When anaplasia is diffuse, it is associated with an unfavorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Kidney Wilms Tumor

Professional guidelines

PubMed

Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Management of bilateral Wilms tumours.
Millar AJW, Cox S, Davidson A
Pediatr Surg Int 2017 Jul;33(7):737-745. Epub 2017 May 17 doi: 10.1007/s00383-017-4091-6. PMID: 28516188
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101

Recent clinical studies

Therapy

Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children's Oncology Group Study AREN0534.
Ehrlich PF, Tornwall B, Chintagumpala MM, Chi YY, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Fernandez CV, Dome JS
Ann Surg Oncol 2022 May;29(5):3252-3261. Epub 2022 Jan 24 doi: 10.1245/s10434-021-11266-6. PMID: 35072864Free PMC Article
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101
Current and emerging chemotherapy treatment strategies for Wilms tumor in North America.
Gratias EJ, Dome JS
Paediatr Drugs 2008;10(2):115-24. doi: 10.2165/00148581-200810020-00006. PMID: 18345721
Wilms tumour: prognostic factors, staging, therapy and late effects.
Kaste SC, Dome JS, Babyn PS, Graf NM, Grundy P, Godzinski J, Levitt GA, Jenkinson H
Pediatr Radiol 2008 Jan;38(1):2-17. Epub 2007 Nov 17 doi: 10.1007/s00247-007-0687-7. PMID: 18026723
Preoperative therapy for intracaval and atrial extension of Wilms tumor.
Ritchey ML, Kelalis PP, Haase GM, Shochat SJ, Green DM, D'Angio G
Cancer 1993 Jun 15;71(12):4104-10. doi: 10.1002/1097-0142(19930615)71:12<4104::aid-cncr2820711249>3.0.co;2-7. PMID: 8389661

Prognosis

Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors.
Su X, Lu X, Bazai SK, Dainese L, Verschuur A, Dumont B, Mouawad R, Xu L, Cheng W, Yan F, Irtan S, Lindner V, Paillard C, Le Bouc Y, Coulomb A, Malouf GG
Nat Commun 2023 Nov 30;14(1):7884. doi: 10.1038/s41467-023-43290-3. PMID: 38036539Free PMC Article
Children's Oncology Group's 2023 blueprint for research: Renal tumors.
Geller JI, Hong AL, Vallance KL, Evageliou N, Aldrink JH, Cost NG, Treece AL, Renfro LA, Mullen EA; COG Renal Tumor Committee
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30586. Epub 2023 Jul 21 doi: 10.1002/pbc.30586. PMID: 37477907Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Management of bilateral Wilms tumours.
Millar AJW, Cox S, Davidson A
Pediatr Surg Int 2017 Jul;33(7):737-745. Epub 2017 May 17 doi: 10.1007/s00383-017-4091-6. PMID: 28516188
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101

Clinical prediction guides

A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage.
Uno K, Rastegar B, Jansson C, Durand G, Valind A, Chattopadhyay S, Bertolotti A, Ciceri S, Spreafico F, Collini P, Perotti D, Mengelbier LH, Gisselsson D
Mod Pathol 2024 Jan;37(1):100382. Epub 2023 Nov 10 doi: 10.1016/j.modpat.2023.100382. PMID: 37951357
Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors.
Su X, Lu X, Bazai SK, Dainese L, Verschuur A, Dumont B, Mouawad R, Xu L, Cheng W, Yan F, Irtan S, Lindner V, Paillard C, Le Bouc Y, Coulomb A, Malouf GG
Nat Commun 2023 Nov 30;14(1):7884. doi: 10.1038/s41467-023-43290-3. PMID: 38036539Free PMC Article
Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor.
Cai L, Shi B, Zhu K, Zhong X, Lai D, Wang J, Tou J
Sci Rep 2023 Sep 16;13(1):15404. doi: 10.1038/s41598-023-42730-w. PMID: 37717078Free PMC Article
Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.
Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C
Pediatr Blood Cancer 2022 Feb;69(2):e29401. Epub 2021 Oct 24 doi: 10.1002/pbc.29401. PMID: 34693628Free PMC Article
Wilms tumor: "State-of-the-art" update, 2016.
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727

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