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Anaplastic Kidney Wilms Tumor

MedGen UID:
231375
Concept ID:
C1332289
Neoplastic Process
Synonyms: Anaplastic Renal Wilm's Tumor; Anaplastic Renal Wilms Tumor; Anaplastic Renal Wilms' Tumor

Definition

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia. Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia. When anaplasia is diffuse, it is associated with an unfavorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Kidney Wilms Tumor

Professional guidelines

PubMed

Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101

Recent clinical studies

Etiology

Geller JI, Hong AL, Vallance KL, Evageliou N, Aldrink JH, Cost NG, Treece AL, Renfro LA, Mullen EA; COG Renal Tumor Committee
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30586. Epub 2023 Jul 21 doi: 10.1002/pbc.30586. PMID: 37477907Free PMC Article
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Cox S, Büyükünal C, Millar AJW
Pediatr Surg Int 2020 Feb;36(2):113-127. Epub 2019 Nov 7 doi: 10.1007/s00383-019-04596-w. PMID: 31701302
Bright RK, Bright JD, Byrne JA
Hum Vaccin Immunother 2014;10(11):3297-305. doi: 10.4161/hv.29475. PMID: 25483660Free PMC Article
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Diagnosis

Geller JI, Hong AL, Vallance KL, Evageliou N, Aldrink JH, Cost NG, Treece AL, Renfro LA, Mullen EA; COG Renal Tumor Committee
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30586. Epub 2023 Jul 21 doi: 10.1002/pbc.30586. PMID: 37477907Free PMC Article
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Millar AJW, Cox S, Davidson A
Pediatr Surg Int 2017 Jul;33(7):737-745. Epub 2017 May 17 doi: 10.1007/s00383-017-4091-6. PMID: 28516188
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Therapy

Ehrlich PF, Tornwall B, Chintagumpala MM, Chi YY, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Fernandez CV, Dome JS
Ann Surg Oncol 2022 May;29(5):3252-3261. Epub 2022 Jan 24 doi: 10.1245/s10434-021-11266-6. PMID: 35072864Free PMC Article
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101
Gratias EJ, Dome JS
Paediatr Drugs 2008;10(2):115-24. doi: 10.2165/00148581-200810020-00006. PMID: 18345721
Kaste SC, Dome JS, Babyn PS, Graf NM, Grundy P, Godzinski J, Levitt GA, Jenkinson H
Pediatr Radiol 2008 Jan;38(1):2-17. Epub 2007 Nov 17 doi: 10.1007/s00247-007-0687-7. PMID: 18026723
Ritchey ML, Kelalis PP, Haase GM, Shochat SJ, Green DM, D'Angio G
Cancer 1993 Jun 15;71(12):4104-10. doi: 10.1002/1097-0142(19930615)71:12<4104::aid-cncr2820711249>3.0.co;2-7. PMID: 8389661

Prognosis

Su X, Lu X, Bazai SK, Dainese L, Verschuur A, Dumont B, Mouawad R, Xu L, Cheng W, Yan F, Irtan S, Lindner V, Paillard C, Le Bouc Y, Coulomb A, Malouf GG
Nat Commun 2023 Nov 30;14(1):7884. doi: 10.1038/s41467-023-43290-3. PMID: 38036539Free PMC Article
Geller JI, Hong AL, Vallance KL, Evageliou N, Aldrink JH, Cost NG, Treece AL, Renfro LA, Mullen EA; COG Renal Tumor Committee
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30586. Epub 2023 Jul 21 doi: 10.1002/pbc.30586. PMID: 37477907Free PMC Article
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727
Yu X, Li Z, Chan MT, Wu WK
Tumour Biol 2016 Feb;37(2):1445-50. Epub 2015 Dec 3 doi: 10.1007/s13277-015-4514-8. PMID: 26634744

Clinical prediction guides

Su X, Lu X, Bazai SK, Dainese L, Verschuur A, Dumont B, Mouawad R, Xu L, Cheng W, Yan F, Irtan S, Lindner V, Paillard C, Le Bouc Y, Coulomb A, Malouf GG
Nat Commun 2023 Nov 30;14(1):7884. doi: 10.1038/s41467-023-43290-3. PMID: 38036539Free PMC Article
Cai L, Shi B, Zhu K, Zhong X, Lai D, Wang J, Tou J
Sci Rep 2023 Sep 16;13(1):15404. doi: 10.1038/s41598-023-42730-w. PMID: 37717078Free PMC Article
Ehrlich PF, Tornwall B, Chintagumpala MM, Chi YY, Hoffer FA, Perlman EJ, Kalapurakal JA, Warwick A, Shamberger RC, Khanna G, Hamilton TE, Gow KW, Paulino AC, Gratias EJ, Mullen EA, Geller JI, Fernandez CV, Dome JS
Ann Surg Oncol 2022 May;29(5):3252-3261. Epub 2022 Jan 24 doi: 10.1245/s10434-021-11266-6. PMID: 35072864Free PMC Article
Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C
Pediatr Blood Cancer 2022 Feb;69(2):e29401. Epub 2021 Oct 24 doi: 10.1002/pbc.29401. PMID: 34693628Free PMC Article
Irtan S, Ehrlich PF, Pritchard-Jones K
Semin Pediatr Surg 2016 Oct;25(5):250-256. Epub 2016 Sep 4 doi: 10.1053/j.sempedsurg.2016.09.003. PMID: 27955727

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