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Basaloid large cell lung carcinoma

MedGen UID:
231419
•Concept ID:
C1332463
•
Neoplastic Process
Synonyms: basaloid large cell carcinoma of the lung; basaloid large cell lung carcinoma; basaloid lung carcinoma; Lung Basaloid Large Cell Carcinoma
 
Monarch Initiative: MONDO:0004087

Definition

A large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripheral palisading, and comedo type necrosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasaloid large cell lung carcinoma

Recent clinical studies

Etiology

The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Comprehensive pathological analyses in lung squamous cell carcinoma: single cell invasion, nuclear diameter, and tumor budding are independent prognostic factors for worse outcomes.
Kadota K, Nitadori J, Woo KM, Sima CS, Finley DJ, Rusch VW, Adusumilli PS, Travis WD
J Thorac Oncol 2014 Aug;9(8):1126-39. doi: 10.1097/JTO.0000000000000253. PMID: 24942260Free PMC Article
Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity.
Kusafuka K, Abe M, Iida Y, Onitsuka T, Fuke T, Asano R, Kamijo T, Nakajima T
J Clin Pathol 2012 Aug;65(8):704-9. Epub 2012 Jun 20 doi: 10.1136/jclinpath-2012-200801. PMID: 22718848Free PMC Article
Large-cell lung carcinoma with basaloid architecture and neuroendocrine differentiation: a new type of combined large-cell neuroendocrine carcinoma.
Morbini P, Inghilleri S
Int J Surg Pathol 2011 Apr;19(2):252-8. Epub 2010 Dec 2 doi: 10.1177/1066896910382905. PMID: 21131317
Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma.
Li LS, Kim H, Rhee H, Kim SH, Shin DH, Chung KY, Park KS, Paik YK, Chang J, Kim H
Proteomics 2004 Nov;4(11):3394-400. doi: 10.1002/pmic.200400901. PMID: 15378762

Diagnosis

POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC.
Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N
J Thorac Oncol 2022 Sep;17(9):1109-1121. Epub 2022 Jun 24 doi: 10.1016/j.jtho.2022.06.004. PMID: 35760287Free PMC Article
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Large cell carcinoma of lung: On the verge of extinction?
Weissferdt A
Semin Diagn Pathol 2014 Jul;31(4):278-88. Epub 2014 Jun 12 doi: 10.1053/j.semdp.2014.06.005. PMID: 25023633
Large cell carcinoma of the lung: an endangered species?
Pardo J, Martinez-Peñuela AM, Sola JJ, Panizo A, Gúrpide A, Martinez-Peñuela JM, Lozano MD
Appl Immunohistochem Mol Morphol 2009 Oct;17(5):383-92. doi: 10.1097/PAI.0b013e31819bfd59. PMID: 19444077

Therapy

Basaloid large cell lung carcinoma presenting concurrently with metastatic uveal tumor.
Hasturk S, Soylu M, Zeren EH, Hanta I
Lung Cancer 2001 Apr;32(1):95-101. doi: 10.1016/s0169-5002(00)00202-6. PMID: 11282434

Prognosis

NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Basaloid squamous cell carcinoma of the sinonasal tract with metastasis to the liver: a case report and literature review.
Toe BP, Ramli N, Lam SY, Wong KT, Prepageran N
Ear Nose Throat J 2015 Feb;94(2):E27-32. doi: 10.1177/014556131509400216. PMID: 25651356
Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity.
Kusafuka K, Abe M, Iida Y, Onitsuka T, Fuke T, Asano R, Kamijo T, Nakajima T
J Clin Pathol 2012 Aug;65(8):704-9. Epub 2012 Jun 20 doi: 10.1136/jclinpath-2012-200801. PMID: 22718848Free PMC Article
The new World Health Organization classification of lung tumours.
Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y
Eur Respir J 2001 Dec;18(6):1059-68. doi: 10.1183/09031936.01.00275301. PMID: 11829087
Basal cell (basaloid) carcinoma of the lung: a new morphologic and phenotypic entity with separate prognostic significance.
Brambilla E, Moro D, Veale D, Brichon PY, Stoebner P, Paramelle B, Brambilla C
Hum Pathol 1992 Sep;23(9):993-1003. doi: 10.1016/0046-8177(92)90260-a. PMID: 1381335

Clinical prediction guides

NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Increased frequency of bronchiolar histotypes in lung carcinomas associated with idiopathic pulmonary fibrosis.
Caliò A, Lever V, Rossi A, Gilioli E, Brunelli M, Dubini A, Tomassetti S, Piciucchi S, Nottegar A, Rossi G, Kambouchner M, Cancellieri A, Barbareschi M, Pelosi G, Doglioni C, Cavazza A, Carella R, Graziano P, Murer B, Poletti V, Chilosi M
Histopathology 2017 Nov;71(5):725-735. Epub 2017 Aug 4 doi: 10.1111/his.13269. PMID: 28556957
Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study.
Thunnissen E, Noguchi M, Aisner S, Beasley MB, Brambilla E, Chirieac LR, Chung JH, Dacic S, Geisinger KR, Hirsch FR, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL, Pelosi G, Petersen I, Roggli V, Travis WD, Wistuba I, Yatabe Y, Dziadziuszko R, Witte B, Tsao MS, Nicholson AG
J Thorac Oncol 2014 Sep;9(9):1354-62. doi: 10.1097/JTO.0000000000000264. PMID: 25122431
Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity.
Kusafuka K, Abe M, Iida Y, Onitsuka T, Fuke T, Asano R, Kamijo T, Nakajima T
J Clin Pathol 2012 Aug;65(8):704-9. Epub 2012 Jun 20 doi: 10.1136/jclinpath-2012-200801. PMID: 22718848Free PMC Article
Large-cell lung carcinoma with basaloid architecture and neuroendocrine differentiation: a new type of combined large-cell neuroendocrine carcinoma.
Morbini P, Inghilleri S
Int J Surg Pathol 2011 Apr;19(2):252-8. Epub 2010 Dec 2 doi: 10.1177/1066896910382905. PMID: 21131317

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