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Benign Cardiac Germ Cell Tumor

MedGen UID:
231422
•Concept ID:
C1332478
•
Neoplastic Process
Synonyms: Benign Cardiac Germ Cell Neoplasm; Benign Germ Cell Neoplasm of Heart; Benign Germ Cell Neoplasm of the Heart; Benign Germ Cell Tumor of Heart; Benign Germ Cell Tumor of the Heart; Benign Heart Germ Cell Neoplasm; Benign Heart Germ Cell Tumor

Definition

A germ cell tumor that arises within the myocardium or cardiac chambers. There is no evidence of atypia or metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Cardiac Germ Cell Tumor

Professional guidelines

PubMed

Prenatal Diagnosis and Outcome of Intrapericardial Teratoma: Report of Two Clinical Scenarios.
Martínez-García A, Cervantes-Salazar J, Copado-Mendoza DY, Aranda-Fraustro A, Barrera-Valdivieso MA, Pereira-López GI, Calderón-Colmenero J
World J Pediatr Congenit Heart Surg 2023 Jan;14(1):88-90. Epub 2022 Oct 16 doi: 10.1177/21501351221129189. PMID: 36250319
Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force.
Ku EJ, Kim KJ, Kim JH, Kim MK, Ahn CH, Lee KA, Lee SH, Lee YB, Park KH, Choi YM, Hong N, Hong AR, Kang SW, Park BK, Seong MW, Kim M, Jung KC, Jung CK, Cho YS, Paeng JC, Kim JH, Ryu OH, Rhee Y, Kim CH, Lee EJ
Endocrinol Metab (Seoul) 2021 Apr;36(2):322-338. Epub 2021 Apr 6 doi: 10.3803/EnM.2020.908. PMID: 33820394Free PMC Article
Differential diagnosis of the patient with unexplained flushing/anaphylaxis.
Metcalfe DD
Allergy Asthma Proc 2000 Jan-Feb;21(1):21-4. doi: 10.2500/108854100778249006. PMID: 10748948

Recent clinical studies

Etiology

Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.
Stephenson SEM, Costain G, Blok LER, Silk MA, Nguyen TB, Dong X, Alhuzaimi DE, Dowling JJ, Walker S, Amburgey K, Hayeems RZ, Rodan LH, Schwartz MA, Picker J, Lynch SA, Gupta A, Rasmussen KJ, Schimmenti LA, Klee EW, Niu Z, Agre KE, Chilton I, Chung WK, Revah-Politi A, Au PYB, Griffith C, Racobaldo M, Raas-Rothschild A, Ben Zeev B, Barel O, Moutton S, Morice-Picard F, Carmignac V, Cornaton J, Marle N, Devinsky O, Stimach C, Wechsler SB, Hainline BE, Sapp K, Willems M, Bruel AL, Dias KR, Evans CA, Roscioli T, Sachdev R, Temple SEL, Zhu Y, Baker JJ, Scheffer IE, Gardiner FJ, Schneider AL, Muir AM, Mefford HC, Crunk A, Heise EM, Millan F, Monaghan KG, Person R, Rhodes L, Richards S, Wentzensen IM, Cogné B, Isidor B, Nizon M, Vincent M, Besnard T, Piton A, Marcelis C, Kato K, Koyama N, Ogi T, Goh ES, Richmond C, Amor DJ, Boyce JO, Morgan AT, Hildebrand MS, Kaspi A, Bahlo M, Friðriksdóttir R, Katrínardóttir H, Sulem P, Stefánsson K, Björnsson HT, Mandelstam S, Morleo M, Mariani M; TUDP Study Group, Scala M, Accogli A, Torella A, Capra V, Wallis M, Jansen S, Weisfisz Q, de Haan H, Sadedin S; Broad Center for Mendelian Genomics, Lim SC, White SM, Ascher DB, Schenck A, Lockhart PJ, Christodoulou J, Tan TY
Am J Hum Genet 2022 Apr 7;109(4):601-617. doi: 10.1016/j.ajhg.2022.03.002. PMID: 35395208Free PMC Article
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.
Zhao Q, Liu Y, Zhang Y, Meng L, Wei J, Wang B, Wang H, Xin Y, Dong L, Jiang X
Crit Rev Oncol Hematol 2020 May;149:102924. Epub 2020 Mar 3 doi: 10.1016/j.critrevonc.2020.102924. PMID: 32172225
Red face revisited: Flushing.
İkizoğlu G
Clin Dermatol 2014 Nov-Dec;32(6):800-8. Epub 2014 Mar 1 doi: 10.1016/j.clindermatol.2014.02.019. PMID: 25441473
Cardiac tumors.
Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689
Teratomas in childhood.
Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

Diagnosis

Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Fetal intrapericardial teratomas.
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Management of fetal teratomas.
Peiró JL, Sbragia L, Scorletti F, Lim FY, Shaaban A
Pediatr Surg Int 2016 Jul;32(7):635-47. Epub 2016 Apr 25 doi: 10.1007/s00383-016-3892-3. PMID: 27112491
Red face revisited: Flushing.
İkizoğlu G
Clin Dermatol 2014 Nov-Dec;32(6):800-8. Epub 2014 Mar 1 doi: 10.1016/j.clindermatol.2014.02.019. PMID: 25441473
Cardiac tumors.
Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689

Therapy

Factors associated with postoperative complications and costs for adrenalectomy in benign adrenal disorders.
Sung TY, Tennakoon L, Alobuia WM, Seib C, Cisco R, Lin D, Kebebew E
Surgery 2022 Jun;171(6):1519-1525. Epub 2021 Nov 29 doi: 10.1016/j.surg.2021.10.065. PMID: 34857386
Primary Ovarian Carcinoid: Extensive Clinical Experience With an Underrecognized Uncommon Entity.
Preda VA, Chitoni M, Talbot D, Reed N, Grossman AB
Int J Gynecol Cancer 2018 Mar;28(3):466-471. doi: 10.1097/IGC.0000000000001215. PMID: 29420361
Clinical Case of the Month: A 57-Year-Old Man with an Axillary Mass.
Desai P, Myers A, Boulmay B, Lopez FA
J La State Med Soc 2017 May-Jun;169(3):78-82. Epub 2017 Jun 23 PMID: 28644156
Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex.
MacKeigan JP, Krueger DA
Neuro Oncol 2015 Dec;17(12):1550-9. Epub 2015 Aug 19 doi: 10.1093/neuonc/nov152. PMID: 26289591Free PMC Article
Neoplasia of early life and its relationships to teratogenesis.
Bolande RP
Perspect Pediatr Pathol 1976;3:145-83. PMID: 184428

Prognosis

Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.
Stephenson SEM, Costain G, Blok LER, Silk MA, Nguyen TB, Dong X, Alhuzaimi DE, Dowling JJ, Walker S, Amburgey K, Hayeems RZ, Rodan LH, Schwartz MA, Picker J, Lynch SA, Gupta A, Rasmussen KJ, Schimmenti LA, Klee EW, Niu Z, Agre KE, Chilton I, Chung WK, Revah-Politi A, Au PYB, Griffith C, Racobaldo M, Raas-Rothschild A, Ben Zeev B, Barel O, Moutton S, Morice-Picard F, Carmignac V, Cornaton J, Marle N, Devinsky O, Stimach C, Wechsler SB, Hainline BE, Sapp K, Willems M, Bruel AL, Dias KR, Evans CA, Roscioli T, Sachdev R, Temple SEL, Zhu Y, Baker JJ, Scheffer IE, Gardiner FJ, Schneider AL, Muir AM, Mefford HC, Crunk A, Heise EM, Millan F, Monaghan KG, Person R, Rhodes L, Richards S, Wentzensen IM, Cogné B, Isidor B, Nizon M, Vincent M, Besnard T, Piton A, Marcelis C, Kato K, Koyama N, Ogi T, Goh ES, Richmond C, Amor DJ, Boyce JO, Morgan AT, Hildebrand MS, Kaspi A, Bahlo M, Friðriksdóttir R, Katrínardóttir H, Sulem P, Stefánsson K, Björnsson HT, Mandelstam S, Morleo M, Mariani M; TUDP Study Group, Scala M, Accogli A, Torella A, Capra V, Wallis M, Jansen S, Weisfisz Q, de Haan H, Sadedin S; Broad Center for Mendelian Genomics, Lim SC, White SM, Ascher DB, Schenck A, Lockhart PJ, Christodoulou J, Tan TY
Am J Hum Genet 2022 Apr 7;109(4):601-617. doi: 10.1016/j.ajhg.2022.03.002. PMID: 35395208Free PMC Article
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Fetal intrapericardial teratomas.
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Cardiac tumors.
Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128

Clinical prediction guides

Catecholamine-induced cardiomyopathy - a clinical case.
Vladimirova-Kitova L, Kitov S, Uchikov P, Pavlov G
Folia Med (Plovdiv) 2022 Feb 28;64(1):156-161. doi: 10.3897/folmed.64.e63215. PMID: 35851895
Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.
Stephenson SEM, Costain G, Blok LER, Silk MA, Nguyen TB, Dong X, Alhuzaimi DE, Dowling JJ, Walker S, Amburgey K, Hayeems RZ, Rodan LH, Schwartz MA, Picker J, Lynch SA, Gupta A, Rasmussen KJ, Schimmenti LA, Klee EW, Niu Z, Agre KE, Chilton I, Chung WK, Revah-Politi A, Au PYB, Griffith C, Racobaldo M, Raas-Rothschild A, Ben Zeev B, Barel O, Moutton S, Morice-Picard F, Carmignac V, Cornaton J, Marle N, Devinsky O, Stimach C, Wechsler SB, Hainline BE, Sapp K, Willems M, Bruel AL, Dias KR, Evans CA, Roscioli T, Sachdev R, Temple SEL, Zhu Y, Baker JJ, Scheffer IE, Gardiner FJ, Schneider AL, Muir AM, Mefford HC, Crunk A, Heise EM, Millan F, Monaghan KG, Person R, Rhodes L, Richards S, Wentzensen IM, Cogné B, Isidor B, Nizon M, Vincent M, Besnard T, Piton A, Marcelis C, Kato K, Koyama N, Ogi T, Goh ES, Richmond C, Amor DJ, Boyce JO, Morgan AT, Hildebrand MS, Kaspi A, Bahlo M, Friðriksdóttir R, Katrínardóttir H, Sulem P, Stefánsson K, Björnsson HT, Mandelstam S, Morleo M, Mariani M; TUDP Study Group, Scala M, Accogli A, Torella A, Capra V, Wallis M, Jansen S, Weisfisz Q, de Haan H, Sadedin S; Broad Center for Mendelian Genomics, Lim SC, White SM, Ascher DB, Schenck A, Lockhart PJ, Christodoulou J, Tan TY
Am J Hum Genet 2022 Apr 7;109(4):601-617. doi: 10.1016/j.ajhg.2022.03.002. PMID: 35395208Free PMC Article
Fetal intrapericardial teratomas.
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Sacrococcygeal teratoma. Outcome and management. An analysis of 17 cases.
Perrelli L, D'Urzo C, Manzoni C, Pintus C, De Santis M, Masini L, Noia G
J Perinat Med 2002;30(2):179-84. doi: 10.1515/JPM.2002.024. PMID: 12012641
Unusual primary tumors of the heart.
Vander Salm TJ
Semin Thorac Cardiovasc Surg 2000 Apr;12(2):89-100. doi: 10.1053/ct.2000.5080. PMID: 10807431

Recent systematic reviews

Diagnostic test accuracy meta-analysis of PRAME in distinguishing primary cutaneous melanomas from benign melanocytic lesions.
Kunc M, Żemierowska N, Skowronek F, Biernat W
Histopathology 2023 Jul;83(1):3-14. Epub 2023 Mar 21 doi: 10.1111/his.14904. PMID: 36942814

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