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Childhood Benign Central Nervous System Neoplasm

MedGen UID:
231426
•Concept ID:
C1332483
•
Neoplastic Process
Synonyms: Benign Childhood Central Nervous System Neoplasm; Benign Childhood Central Nervous System Tumor; Benign Childhood CNS Neoplasm; Benign Childhood CNS Tumor; Benign Childhood Neoplasm of Central Nervous System; Benign Childhood Neoplasm of CNS; Benign Childhood Neoplasm of the Central Nervous System; Benign Childhood Neoplasm of the CNS; Benign Childhood Tumor of Central Nervous System; Benign Childhood Tumor of CNS; Benign Childhood Tumor of the Central Nervous System; Benign Childhood Tumor of the CNS; Benign Pediatric Central Nervous System Neoplasm; Benign Pediatric Central Nervous System Tumor; Benign Pediatric CNS Neoplasm; Benign Pediatric CNS Tumor; Benign Pediatric Neoplasm of Central Nervous System; Benign Pediatric Neoplasm of CNS; Benign Pediatric Neoplasm of the Central Nervous System; Benign Pediatric Neoplasm of the CNS; Benign Pediatric Tumor of Central Nervous System; Benign Pediatric Tumor of CNS; Benign Pediatric Tumor of the Central Nervous System; Benign Pediatric Tumor of the CNS

Definition

A childhood neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
J Med Genet 2022 Apr;59(4):318-327. Epub 2021 Feb 23 doi: 10.1136/jmedgenet-2020-107627. PMID: 33622763
Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges.
Pollack IF
J Neurosurg Pediatr 2011 Aug;8(2):135-48. doi: 10.3171/2011.5.PEDS1178. PMID: 21806354

Recent clinical studies

Etiology

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
J Med Genet 2022 Apr;59(4):318-327. Epub 2021 Feb 23 doi: 10.1136/jmedgenet-2020-107627. PMID: 33622763
Risk factors for childhood and adult primary brain tumors.
Ostrom QT, Adel Fahmideh M, Cote DJ, Muskens IS, Schraw JM, Scheurer ME, Bondy ML
Neuro Oncol 2019 Nov 4;21(11):1357-1375. doi: 10.1093/neuonc/noz123. PMID: 31301133Free PMC Article
Central nervous system tumors.
Jacques G, Cormac O
Handb Clin Neurol 2013;112:931-58. doi: 10.1016/B978-0-444-52910-7.00015-5. PMID: 23622303

Diagnosis

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
J Med Genet 2022 Apr;59(4):318-327. Epub 2021 Feb 23 doi: 10.1136/jmedgenet-2020-107627. PMID: 33622763
Risk factors for childhood and adult primary brain tumors.
Ostrom QT, Adel Fahmideh M, Cote DJ, Muskens IS, Schraw JM, Scheurer ME, Bondy ML
Neuro Oncol 2019 Nov 4;21(11):1357-1375. doi: 10.1093/neuonc/noz123. PMID: 31301133Free PMC Article
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Central nervous system tumors.
Jacques G, Cormac O
Handb Clin Neurol 2013;112:931-58. doi: 10.1016/B978-0-444-52910-7.00015-5. PMID: 23622303

Therapy

GH and Childhood-onset Craniopharyngioma: When to Initiate GH Replacement Therapy?
Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis.
Lopes J, Baudin C, Leuraud K, Klokov D, Bernier MO
Sci Rep 2022 Sep 28;12(1):16209. doi: 10.1038/s41598-022-20462-7. PMID: 36171442Free PMC Article
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Cancer risks from medical radiation.
Ron E
Health Phys 2003 Jul;85(1):47-59. doi: 10.1097/00004032-200307000-00011. PMID: 12852471

Prognosis

Incidence trends of childhood central nervous system tumors in Finland 1990-2017.
Abuhamed J, Nikkilä A, Raitanen J, Alimam W, Lohi O, Pitkäniemi J, Haapasalo H, Auvinen A
BMC Cancer 2022 Jul 18;22(1):784. doi: 10.1186/s12885-022-09862-0. PMID: 35850678Free PMC Article
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Central nervous system tumors.
Jacques G, Cormac O
Handb Clin Neurol 2013;112:931-58. doi: 10.1016/B978-0-444-52910-7.00015-5. PMID: 23622303
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382

Clinical prediction guides

Incidence trends of childhood central nervous system tumors in Finland 1990-2017.
Abuhamed J, Nikkilä A, Raitanen J, Alimam W, Lohi O, Pitkäniemi J, Haapasalo H, Auvinen A
BMC Cancer 2022 Jul 18;22(1):784. doi: 10.1186/s12885-022-09862-0. PMID: 35850678Free PMC Article
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 2 and Related Disorders.
Evans DGR, Salvador H, Chang VY, Erez A, Voss SD, Druker H, Scott HS, Tabori U
Clin Cancer Res 2017 Jun 15;23(12):e54-e61. doi: 10.1158/1078-0432.CCR-17-0590. PMID: 28620005
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382

Recent systematic reviews

Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis.
Lopes J, Baudin C, Leuraud K, Klokov D, Bernier MO
Sci Rep 2022 Sep 28;12(1):16209. doi: 10.1038/s41598-022-20462-7. PMID: 36171442Free PMC Article
Intracystic bleomycin for cystic craniopharyngiomas in children.
Zhang S, Fang Y, Cai BW, Xu JG, You C
Cochrane Database Syst Rev 2016 Jul 14;7(7):CD008890. doi: 10.1002/14651858.CD008890.pub4. PMID: 27416004Free PMC Article
Intracystic bleomycin for cystic craniopharyngiomas in children.
Zheng J, Fang Y, Cai BW, Zhang H, Liu W, Wu B, Xu JG, You C
Cochrane Database Syst Rev 2014 Sep 19;(9):CD008890. doi: 10.1002/14651858.CD008890.pub3. PMID: 25233847
Intracystic bleomycin for cystic craniopharyngiomas in children (abridged republication of cochrane systematic review).
Liu W, Fang Y, Cai B, Xu J, You C, Zhang H
Neurosurgery 2012 Nov;71(5):909-15. doi: 10.1227/NEU.0b013e31826d5c31. PMID: 22902333
Childhood ependymoma: a systematic review of treatment options and strategies.
Grill J, Pascal C, Chantal K
Paediatr Drugs 2003;5(8):533-43. doi: 10.2165/00148581-200305080-00004. PMID: 12895136

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