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Benign Gastric Soft Tissue Neoplasm

MedGen UID:
231430
•Concept ID:
C1332504
•
Neoplastic Process
Synonyms: Benign Soft Tissue Neoplasm of Stomach; Benign Soft Tissue Neoplasm of the Stomach

Definition

A mesenchymal neoplasm that arises from the stomach and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, lipoma, and hemangioma. [from NCI]

Professional guidelines

PubMed

Gastrointestinal schwannomas: a rare but important differential diagnosis of mesenchymal tumors of gastrointestinal tract.
Mekras A, Krenn V, Perrakis A, Croner RS, Kalles V, Atamer C, Grützmann R, Vassos N
BMC Surg 2018 Jul 25;18(1):47. doi: 10.1186/s12893-018-0379-2. PMID: 30045739Free PMC Article
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.
Miettinen M, Lasota J
Virchows Arch 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. PMID: 11213830
Surgical treatment of soft tissue tumors of the stomach.
Lehnert T, Sinn HP, Waldherr R, Herfarth C
Eur J Surg Oncol 1990 Aug;16(4):352-9. PMID: 2379593

Recent clinical studies

Etiology

Gastrointestinal schwannomas: a rare but important differential diagnosis of mesenchymal tumors of gastrointestinal tract.
Mekras A, Krenn V, Perrakis A, Croner RS, Kalles V, Atamer C, Grützmann R, Vassos N
BMC Surg 2018 Jul 25;18(1):47. doi: 10.1186/s12893-018-0379-2. PMID: 30045739Free PMC Article
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Liver resection for non-colorectal non-neuroendocrine metastases.
Clarke NAR, Kanhere HA, Trochsler MI, Maddern GJ
ANZ J Surg 2018 Apr;88(4):E313-E317. Epub 2016 Aug 3 doi: 10.1111/ans.13700. PMID: 27490345
Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.
Miettinen M, Makhlouf HR, Sobin LH, Lasota J
Am J Surg Pathol 2009 Nov;33(11):1624-32. doi: 10.1097/PAS.0b013e3181ae666a. PMID: 19675452
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Unsuspected gastric glomus tumour.
Stahl C, Wong WG, Fanburg-Smith JC, Vining CC
BMJ Case Rep 2023 Jan 27;16(1) doi: 10.1136/bcr-2022-253020. PMID: 36707101Free PMC Article
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.
Miettinen M, Makhlouf HR, Sobin LH, Lasota J
Am J Surg Pathol 2009 Nov;33(11):1624-32. doi: 10.1097/PAS.0b013e3181ae666a. PMID: 19675452
Soft-tissue metastases: their presentation and origin.
Abed R, Grimer RJ, Carter SR, Tillman RM, Abudu A, Jeys L
J Bone Joint Surg Br 2009 Aug;91(8):1083-5. doi: 10.1302/0301-620X.91B8.21680. PMID: 19651839
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.
Miettinen M, Lasota J
Virchows Arch 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. PMID: 11213830

Therapy

Liver resection for non-colorectal non-neuroendocrine metastases.
Clarke NAR, Kanhere HA, Trochsler MI, Maddern GJ
ANZ J Surg 2018 Apr;88(4):E313-E317. Epub 2016 Aug 3 doi: 10.1111/ans.13700. PMID: 27490345
Prognostic factors and survival in patients with gastric stump cancer.
Huang H, Wang W, Chen Z, Jin JJ, Long ZW, Cai H, Liu XW, Zhou Y, Wang YN
World J Gastroenterol 2015 Feb 14;21(6):1865-71. doi: 10.3748/wjg.v21.i6.1865. PMID: 25684953Free PMC Article
Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review.
Miettinen M, El-Rifai W, H L Sobin L, Lasota J
Hum Pathol 2002 May;33(5):478-83. doi: 10.1053/hupa.2002.124123. PMID: 12094372
Burkitt lymphoma associated with large gastric folds, pancreatic involvement, and biliary tract obstruction.
Kurosawa H, Matsunaga T, Shimaoka H, Sato Y, Kuwashima S, Sugita K, Hagane K, Eguchi M
J Pediatr Hematol Oncol 2002 May;24(4):310-2. doi: 10.1097/00043426-200205000-00018. PMID: 11972102
Wound infection after mandibular reconstruction with autogenous graft.
Egyedi P
Ann Acad Med Singap 1986 Jul;15(3):340-5. PMID: 3535624

Prognosis

A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Liver resection for non-colorectal non-neuroendocrine metastases.
Clarke NAR, Kanhere HA, Trochsler MI, Maddern GJ
ANZ J Surg 2018 Apr;88(4):E313-E317. Epub 2016 Aug 3 doi: 10.1111/ans.13700. PMID: 27490345
Prognostic factors and survival in patients with gastric stump cancer.
Huang H, Wang W, Chen Z, Jin JJ, Long ZW, Cai H, Liu XW, Zhou Y, Wang YN
World J Gastroenterol 2015 Feb 14;21(6):1865-71. doi: 10.3748/wjg.v21.i6.1865. PMID: 25684953Free PMC Article
Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review.
Miettinen M, El-Rifai W, H L Sobin L, Lasota J
Hum Pathol 2002 May;33(5):478-83. doi: 10.1053/hupa.2002.124123. PMID: 12094372
Leiomyosarcoma of the gastro-intestinal tract: general pattern of metastasis and recurrence.
Lee YT
Cancer Treat Rev 1983 Jun;10(2):91-101. doi: 10.1016/0305-7372(83)90007-5. PMID: 6347377

Clinical prediction guides

Plexiform fibromyxoma of the stomach: An underrecognized entity!
Goyal S, Beso P, Khullar R, Sakhuja P
Indian J Pathol Microbiol 2023 Apr-Jun;66(2):343-346. doi: 10.4103/IJPM.IJPM_480_20. PMID: 37077079
Frequency of superscan on bone scintigraphy: A systematic review.
Kovacsne A, Kozon I, Bentestuen M, Zacho HD
Clin Physiol Funct Imaging 2023 Sep;43(5):297-304. Epub 2023 Apr 25 doi: 10.1111/cpf.12821. PMID: 37070619
Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases.
An S, Jang J, Min K, Kim MS, Park H, Park YS, Kim J, Lee JH, Song HJ, Kim KJ, Yu E, Hong SM
Hum Pathol 2015 Jun;46(6):813-9. Epub 2015 Feb 26 doi: 10.1016/j.humpath.2015.02.005. PMID: 25882927
CAMTA1 immunostaining is not useful in differentiating epithelioid hemangioendothelioma from its potential mimickers.
Yusıflı Z, Kösemehmetoğlu K
Turk Patoloji Derg 2014;30(3):159-65. doi: 10.5146/tjpath.2014.01272. PMID: 25110239
Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues.
Wang C, Mao J, Redfield S, Mo Y, Lage JM, Zhou X
Exp Mol Pathol 2014 Oct;97(2):259-65. Epub 2014 Jul 30 doi: 10.1016/j.yexmp.2014.07.013. PMID: 25084322Free PMC Article

Recent systematic reviews

Frequency of superscan on bone scintigraphy: A systematic review.
Kovacsne A, Kozon I, Bentestuen M, Zacho HD
Clin Physiol Funct Imaging 2023 Sep;43(5):297-304. Epub 2023 Apr 25 doi: 10.1111/cpf.12821. PMID: 37070619

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