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Bone marrow eosinophilia

MedGen UID:
231453
•Concept ID:
C1332587
•
Finding
Synonyms: Bone Marrow Eosinophilia; Eosinophils increased in bone marrow
 
HPO: HP:0034955

Definition

Count of eosinophils in the bone marrow above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow eosinophilia

Professional guidelines

PubMed

Diagnostic and follow-up eosinophilia is not predictive of outcome in childhood acute myeloid leukemia.
Agarwal R, Vishnubhatla S, Gupta R, Bakhshi S
J Pediatr Hematol Oncol 2011 Mar;33(2):e51-3. doi: 10.1097/MPH.0b013e3181f46a91. PMID: 21285899

Recent clinical studies

Etiology

Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology.
Giannetti MP, Akin C, Hufdhi R, Hamilton MJ, Weller E, van Anrooij B, Lyons JJ, Hornick JL, Pinkus G, Castells M, Pozdnyakova O
J Allergy Clin Immunol 2021 Apr;147(4):1497-1501.e1. Epub 2020 Nov 25 doi: 10.1016/j.jaci.2020.11.017. PMID: 33248113
Diagnostic and follow-up eosinophilia is not predictive of outcome in childhood acute myeloid leukemia.
Agarwal R, Vishnubhatla S, Gupta R, Bakhshi S
J Pediatr Hematol Oncol 2011 Mar;33(2):e51-3. doi: 10.1097/MPH.0b013e3181f46a91. PMID: 21285899
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028
Prognostic implications of a bone marrow histopathologic classification system in mycosis fungoides and the Sézary syndrome.
Graham SJ, Sharpe RW, Steinberg SM, Cotelingam JD, Sausville EA, Foss FM
Cancer 1993 Aug 1;72(3):726-34. doi: 10.1002/1097-0142(19930801)72:3<726::aid-cncr2820720316>3.0.co;2-p. PMID: 8334625
Incidence and clinical importance of bone marrow eosinophilia in Hodgkin's disease (BNLI Report No 29). British National Lymphoma Investigation.
Macintyre EA, Vaughan Hudson B, Vaughan Hudson G, Jelliffe AM, Linch DC
J Clin Pathol 1987 Mar;40(3):245-6. doi: 10.1136/jcp.40.3.245. PMID: 3558856Free PMC Article

Diagnosis

Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology.
Giannetti MP, Akin C, Hufdhi R, Hamilton MJ, Weller E, van Anrooij B, Lyons JJ, Hornick JL, Pinkus G, Castells M, Pozdnyakova O
J Allergy Clin Immunol 2021 Apr;147(4):1497-1501.e1. Epub 2020 Nov 25 doi: 10.1016/j.jaci.2020.11.017. PMID: 33248113
Diagnostic and follow-up eosinophilia is not predictive of outcome in childhood acute myeloid leukemia.
Agarwal R, Vishnubhatla S, Gupta R, Bakhshi S
J Pediatr Hematol Oncol 2011 Mar;33(2):e51-3. doi: 10.1097/MPH.0b013e3181f46a91. PMID: 21285899
Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia.
Asou N, Sanada I, Tanaka K, Hidaka M, Suzushima H, Matsuzaki H, Kawano F, Takatsuki K
Cancer Genet Cytogenet 1992 Jul 15;61(2):197-200. doi: 10.1016/0165-4608(92)90086-n. PMID: 1638503
Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: a report of 18 cases.
Bernard P, Dachary D, Reiffers J, Marit G, Wen Z, Jonveaux P, David B, Lacombe F, Broustet A
Leukemia 1989 Oct;3(10):740-5. PMID: 2779289
Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association.
Arthur DC, Bloomfield CD
Blood 1983 May;61(5):994-8. PMID: 6831056

Therapy

Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22).
Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K, Takahashi Y, Kojima S, Kato K
Int J Hematol 2012 May;95(5):577-80. Epub 2012 Mar 9 doi: 10.1007/s12185-012-1044-7. PMID: 22403058
Alemtuzumab therapy for hypereosinophilic syndrome and chronic eosinophilic leukemia.
Verstovsek S, Tefferi A, Kantarjian H, Manshouri T, Luthra R, Pardanani A, Quintás-Cardama A, Ravandi F, Ault P, Bueso-Ramos C, Cortes JE
Clin Cancer Res 2009 Jan 1;15(1):368-73. doi: 10.1158/1078-0432.CCR-08-1302. PMID: 19118067Free PMC Article
Therapy-related chronic myelomonocytic leukaemia with bone marrow eosinophilia associated with der(11)t(1;11)(q21;q14).
Muroi K, Miyata T, Saito M, Hatake K, Amemiya Y, Miura Y
Acta Haematol 1996;96(4):251-4. doi: 10.1159/000203795. PMID: 8922495
Cyclosporin for hypereosinophilic syndrome.
Zabel P, Schlaak M
Ann Hematol 1991 Jun;62(6):230-1. doi: 10.1007/BF01729838. PMID: 1854886
The hypereosinophilic syndrome: dramatic response to therapeutic intervention.
Parrillo JE, Fauci AS, Wolff SM
Trans Assoc Am Physicians 1977;90:135-44. PMID: 611659

Prognosis

Diagnostic and follow-up eosinophilia is not predictive of outcome in childhood acute myeloid leukemia.
Agarwal R, Vishnubhatla S, Gupta R, Bakhshi S
J Pediatr Hematol Oncol 2011 Mar;33(2):e51-3. doi: 10.1097/MPH.0b013e3181f46a91. PMID: 21285899
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028
Myelodysplastic syndrome with bone marrow eosinophilia: clinical and cytogenetic features.
Matsushima T, Murakami H, Tsuchiya J
Leuk Lymphoma 1994 Nov;15(5-6):491-7. doi: 10.3109/10428199409049753. PMID: 7874007
Blood and bone marrow eosinophilia in malignant tumors. Role and nature of blood and tissue eosinophil colony-stimulating factor(s) in two patients.
Stefanini M, Claustro JC, Motos RA, Bendigo LL
Cancer 1991 Aug 1;68(3):543-8. doi: 10.1002/1097-0142(19910801)68:3<543::aid-cncr2820680317>3.0.co;2-3. PMID: 2065275
Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: a report of 18 cases.
Bernard P, Dachary D, Reiffers J, Marit G, Wen Z, Jonveaux P, David B, Lacombe F, Broustet A
Leukemia 1989 Oct;3(10):740-5. PMID: 2779289

Clinical prediction guides

Diagnostic and follow-up eosinophilia is not predictive of outcome in childhood acute myeloid leukemia.
Agarwal R, Vishnubhatla S, Gupta R, Bakhshi S
J Pediatr Hematol Oncol 2011 Mar;33(2):e51-3. doi: 10.1097/MPH.0b013e3181f46a91. PMID: 21285899
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028
Therapy-related chronic myelomonocytic leukaemia with bone marrow eosinophilia associated with der(11)t(1;11)(q21;q14).
Muroi K, Miyata T, Saito M, Hatake K, Amemiya Y, Miura Y
Acta Haematol 1996;96(4):251-4. doi: 10.1159/000203795. PMID: 8922495
Cytogenetic study of 130 childhood acute nonlymphocytic leukemias.
Leverger G, Bernheim A, Daniel MT, Flandrin G, Schaison G, Berger R
Med Pediatr Oncol 1988;16(4):227-32. doi: 10.1002/mpo.2950160402. PMID: 3419390
A clinicopathologic correlation of the idiopathic hypereosinophilic syndrome. II. Clinical manifestations.
Schooley RT, Flaum MA, Gralnick HR, Fauci AS
Blood 1981 Nov;58(5):1021-6. PMID: 7197566

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