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Benign dermal neurilemmoma

MedGen UID:
231931
•Concept ID:
C1332490
•
Neoplastic Process
Synonyms: Benign Dermal Neurilemmoma; benign dermal neurilemmoma; Benign Dermal Schwannoma; benign dermal schwannoma; Benign Neurilemmoma of Skin; benign neurilemmoma of skin; Benign Neurilemmoma of the Skin; benign neurilemmoma of the skin; Benign Schwannoma of Skin; benign schwannoma of skin; Benign Schwannoma of the Skin; benign schwannoma of the skin; Benign Skin Neurilemmoma; benign skin neurilemmoma; Benign Skin Schwannoma; benign skin schwannoma; Cutaneous Schwannoma; Dermal Schwannoma
 
Monarch Initiative: MONDO:0004134

Definition

A benign schwannoma occurring in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign dermal neurilemmoma

Recent clinical studies

Etiology

Methylation-based classification of benign and malignant peripheral nerve sheath tumors.
Röhrich M, Koelsche C, Schrimpf D, Capper D, Sahm F, Kratz A, Reuss J, Hovestadt V, Jones DT, Bewerunge-Hudler M, Becker A, Weis J, Mawrin C, Mittelbronn M, Perry A, Mautner VF, Mechtersheimer G, Hartmann C, Okuducu AF, Arp M, Seiz-Rosenhagen M, Hänggi D, Heim S, Paulus W, Schittenhelm J, Ahmadi R, Herold-Mende C, Unterberg A, Pfister SM, von Deimling A, Reuss DE
Acta Neuropathol 2016 Jun;131(6):877-87. Epub 2016 Feb 8 doi: 10.1007/s00401-016-1540-6. PMID: 26857854
Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.
Johansson G, Peng PC, Huang PY, Chien HF, Hua KT, Kuo ML, Chen CT, Lee MJ
PLoS One 2014;9(12):e115916. Epub 2014 Dec 31 doi: 10.1371/journal.pone.0115916. PMID: 25551830Free PMC Article
Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety.
Agaram NP, Prakash S, Antonescu CR
Am J Surg Pathol 2005 Aug;29(8):1042-8. PMID: 16006798

Diagnosis

A rare case of cutaneous pseudoglandular schwannoma.
Doan L, Cassarino DS
J Cutan Pathol 2023 Sep;50(9):798-800. Epub 2023 Jun 13 doi: 10.1111/cup.14477. PMID: 37312417
Multiple Cutaneous Solitary Circumscribed Neuroma in a Patient with Neurofibromatosis Type 2: An "Incidentaloma" or New Association?
Arole V, Shaker N, Kim LR, Iwenofu OH
Int J Surg Pathol 2023 Aug;31(5):734-737. Epub 2022 Sep 21 doi: 10.1177/10668969221120782. PMID: 36128789
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Methylation-based classification of benign and malignant peripheral nerve sheath tumors.
Röhrich M, Koelsche C, Schrimpf D, Capper D, Sahm F, Kratz A, Reuss J, Hovestadt V, Jones DT, Bewerunge-Hudler M, Becker A, Weis J, Mawrin C, Mittelbronn M, Perry A, Mautner VF, Mechtersheimer G, Hartmann C, Okuducu AF, Arp M, Seiz-Rosenhagen M, Hänggi D, Heim S, Paulus W, Schittenhelm J, Ahmadi R, Herold-Mende C, Unterberg A, Pfister SM, von Deimling A, Reuss DE
Acta Neuropathol 2016 Jun;131(6):877-87. Epub 2016 Feb 8 doi: 10.1007/s00401-016-1540-6. PMID: 26857854
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258

Therapy

Dermal schwannoma (neurilemmoma): a peculiar foreign body reaction?
Kneitz H, Weyandt G, Meissner C, Gebhart E, Bröcker EB
Am J Dermatopathol 2010 Jun;32(4):367-9. doi: 10.1097/DAD.0b013e3181bb1972. PMID: 20216197

Prognosis

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.
Johansson G, Peng PC, Huang PY, Chien HF, Hua KT, Kuo ML, Chen CT, Lee MJ
PLoS One 2014;9(12):e115916. Epub 2014 Dec 31 doi: 10.1371/journal.pone.0115916. PMID: 25551830Free PMC Article
Hybrid schwannoma/perineurioma: report of 10 Chinese cases supporting a distinctive entity.
Yang X, Zeng Y, Wang J
Int J Surg Pathol 2013 Feb;21(1):22-8. Epub 2012 Jul 25 doi: 10.1177/1066896912454566. PMID: 22832113
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety.
Agaram NP, Prakash S, Antonescu CR
Am J Surg Pathol 2005 Aug;29(8):1042-8. PMID: 16006798

Clinical prediction guides

Plexiform Melanocytic Schwannoma: Report of a Second Case and Overview of a Rare Entity.
Ranson M, Lai J, Van Brenk B, McCalmont TH, Walsh NM
Am J Dermatopathol 2022 Dec 1;44(12):943-947. Epub 2022 Nov 2 doi: 10.1097/DAD.0000000000002311. PMID: 36395450
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Merkel cells in neurofibromas and neurilemomas.
Nahass GT, Penneys NS
Br J Dermatol 1994 Nov;131(5):664-6. doi: 10.1111/j.1365-2133.1994.tb04979.x. PMID: 7528042

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