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Benign Fibroblastic Neoplasm

MedGen UID:
231936
•Concept ID:
C1332501
•
Neoplastic Process
Synonyms: Benign Fibroblastic Tumor; Benign Fibrocytic Neoplasm; Benign Fibrocytic Tumor; Benign Fibrogenic Neoplasm; Benign Fibrogenic Tumor; Benign Fibrous Neoplasm; Benign Fibrous Tumor

Definition

A benign mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts without malignant characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Fibroblastic Neoplasm

Professional guidelines

PubMed

Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Clinical features and management of superficial fibromatoses.
Kelenjian S, Mattjie RA, Franz R, Biedermann T, Brockow K
J Dtsch Dermatol Ges 2019 Apr;17(4):393-397. Epub 2019 Mar 13 doi: 10.1111/ddg.13808. PMID: 30865379
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Recent clinical studies

Etiology

Is wide resection obsolete for desmoid tumors in children and adolescents? Evaluation of histological margins, immunohistochemical markers, and review of literature.
Woltsche N, Gilg MM, Fraissler L, Liegl-Atzwanger B, Beham A, Lackner H, Benesch M, Leithner A
Pediatr Hematol Oncol 2015 Feb;32(1):60-9. Epub 2014 Sep 29 doi: 10.3109/08880018.2014.956905. PMID: 25264623

Diagnosis

CYP1A1 Is a Useful Diagnostic Marker for Angiofibroma of Soft Tissue.
Uemura K, Komatsu M, Hara S, Kawamoto T, Bitoh Y, Itoh T, Hirose T
Am J Surg Pathol 2023 May 1;47(5):547-557. Epub 2023 Mar 6 doi: 10.1097/PAS.0000000000002029. PMID: 36876749
Diagnostic imaging and CEUS findings in a rare case of Desmoid-type fibromatosis. A case report.
Valentino M, Liberatore M, Maghella F, De Soccio V, De Felice C, Messineo D, Drudi FM
J Ultrasound 2018 Sep;21(3):253-257. Epub 2018 Mar 21 doi: 10.1007/s40477-018-0291-8. PMID: 29564660Free PMC Article
Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations.
Cavallini A, Rotelli MT, Lippolis C, Piscitelli D, Digennaro R, Covelli C, Carella N, Accetturo M, Altomare DF
Oncotarget 2017 Jun 27;8(26):41866-41875. doi: 10.18632/oncotarget.16383. PMID: 28418912Free PMC Article
Is wide resection obsolete for desmoid tumors in children and adolescents? Evaluation of histological margins, immunohistochemical markers, and review of literature.
Woltsche N, Gilg MM, Fraissler L, Liegl-Atzwanger B, Beham A, Lackner H, Benesch M, Leithner A
Pediatr Hematol Oncol 2015 Feb;32(1):60-9. Epub 2014 Sep 29 doi: 10.3109/08880018.2014.956905. PMID: 25264623
Aggressive fibromatosis of the larynx: case report and brief review.
Liu Y, Guan GF, Jin CS, Yang JP
J Int Med Res 2011;39(2):682-9. doi: 10.1177/147323001103900239. PMID: 21672375

Prognosis

Is wide resection obsolete for desmoid tumors in children and adolescents? Evaluation of histological margins, immunohistochemical markers, and review of literature.
Woltsche N, Gilg MM, Fraissler L, Liegl-Atzwanger B, Beham A, Lackner H, Benesch M, Leithner A
Pediatr Hematol Oncol 2015 Feb;32(1):60-9. Epub 2014 Sep 29 doi: 10.3109/08880018.2014.956905. PMID: 25264623
Cytogenetic, fluorescence in situ hybridization, and immunohistochemistry studies in a malignant pleural solitary fibrous tumor.
Torres-Olivera FJ, Vargas MT, Torres-Gómez FJ, Trigo I, Díaz M, González-Cámpora R
Cancer Genet Cytogenet 2009 Mar;189(2):122-6. doi: 10.1016/j.cancergencyto.2008.11.004. PMID: 19215794

Clinical prediction guides

Is wide resection obsolete for desmoid tumors in children and adolescents? Evaluation of histological margins, immunohistochemical markers, and review of literature.
Woltsche N, Gilg MM, Fraissler L, Liegl-Atzwanger B, Beham A, Lackner H, Benesch M, Leithner A
Pediatr Hematol Oncol 2015 Feb;32(1):60-9. Epub 2014 Sep 29 doi: 10.3109/08880018.2014.956905. PMID: 25264623

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