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Benign Mediastinal Soft Tissue Neoplasm

MedGen UID:
231938
•Concept ID:
C1332516
•
Neoplastic Process
Synonyms: Benign Soft Tissue Mediastinal Tumor; Benign Soft Tissue Neoplasm of Mediastinum; Benign Soft Tissue Neoplasm of the Mediastinum; Benign Soft Tissue Tumor of Mediastinum; Benign Soft Tissue Tumor of the Mediastinum

Definition

A mesenchymal neoplasm that arises from the mediastinum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include lipoma, leiomyoma, and rhabdomyoma. [from NCI]

Professional guidelines

PubMed

MRI-Based Stepwise Approach to Anterior Mediastinal Cystic Lesions for Diagnosis and Further Management.
Kim JH, Choe J, Kim HK, Lee HY
Korean J Radiol 2023 Jan;24(1):62-78. doi: 10.3348/kjr.2022.0606. PMID: 36606621Free PMC Article
Management of ectopic thyroid nodules.
Kozol RA, Geelhoed GW, Flynn SD, Kinder B
Surgery 1993 Dec;114(6):1103-6; discussion 1106-7. PMID: 8256214
The value of computed tomography in the diagnosis and management of pediatric mediastinal abnormalities.
Siegel MJ, Sagel SS, Reed K
Radiology 1982 Jan;142(1):149-55. doi: 10.1148/radiology.142.1.7053524. PMID: 7053524

Recent clinical studies

Etiology

Transthoracic Fine-Needle Aspiration Cytology of Pulmonary Spindle and Mesenchymal Neoplasms: A Pandora's Box.
Kaur K, Patel T, Patra S, Trivedi P
Acta Cytol 2023;67(4):333-345. Epub 2022 Dec 29 doi: 10.1159/000528843. PMID: 36580900
Myxolipoma of hand in a child: case report of a rare tumor.
Deka JB, Shah MVK, Shah R, Bhatnagar N, Bortolotto C, Jiménez F
J Ultrasound 2023 Mar;26(1):295-300. Epub 2022 Sep 24 doi: 10.1007/s40477-022-00727-7. PMID: 36152213Free PMC Article
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Paravertebral tumours of the cervicothoracic junction extending into the mediastinum: surgical strategies in a no man's land.
Prezerakos GK, Sayal P, Kourliouros A, Pericleous P, Ladas G, Casey A
Eur Spine J 2018 Apr;27(4):902-912. Epub 2018 Feb 14 doi: 10.1007/s00586-018-5512-5. PMID: 29445946

Diagnosis

MRI-Based Stepwise Approach to Anterior Mediastinal Cystic Lesions for Diagnosis and Further Management.
Kim JH, Choe J, Kim HK, Lee HY
Korean J Radiol 2023 Jan;24(1):62-78. doi: 10.3348/kjr.2022.0606. PMID: 36606621Free PMC Article
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Cervical ganglioneuroma: A case report and review of the literature.
Xu T, Zhu W, Wang P
Medicine (Baltimore) 2019 Apr;98(15):e15203. doi: 10.1097/MD.0000000000015203. PMID: 30985715Free PMC Article
Sensitivity and specificity of fine needle aspiration for the diagnosis of mediastinal lesions.
Marcus A, Narula N, Kamel MK, Koizumi J, Port JL, Stiles B, Moreira A, Altorki NK, Giorgadze T
Ann Diagn Pathol 2019 Apr;39:69-73. Epub 2019 Feb 10 doi: 10.1016/j.anndiagpath.2019.02.011. PMID: 30797131
Comprehensive Imaging Review of the Superior Vena Cava.
Sonavane SK, Milner DM, Singh SP, Abdel Aal AK, Shahir KS, Chaturvedi A
Radiographics 2015 Nov-Dec;35(7):1873-92. Epub 2015 Oct 9 doi: 10.1148/rg.2015150056. PMID: 26452112

Therapy

Fat Content Quantification Using Dual-Energy CT for Differentiation of Anterior Mediastinal Lesions from Normal or Hyperplastic Thymus.
Araki T, Hammer M, Sodickson A
Curr Probl Diagn Radiol 2022 May-Jun;51(3):334-339. Epub 2021 Jul 15 doi: 10.1067/j.cpradiol.2021.06.007. PMID: 34364734
Paravertebral tumours of the cervicothoracic junction extending into the mediastinum: surgical strategies in a no man's land.
Prezerakos GK, Sayal P, Kourliouros A, Pericleous P, Ladas G, Casey A
Eur Spine J 2018 Apr;27(4):902-912. Epub 2018 Feb 14 doi: 10.1007/s00586-018-5512-5. PMID: 29445946
A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report.
Jevremovic V, Yousuf A, Hussain Z, Abboud A, Chedrawy EG
J Med Case Rep 2017 Mar 7;11(1):61. doi: 10.1186/s13256-017-1223-5. PMID: 28264709Free PMC Article
Recurrent hyperparathyroidism caused by benign neoplastic seeding: two cases of parathyromatosis and a review of the literature.
Twigt BA, van Dalen T, Vroonhoven TJ, Consten EC
Acta Chir Belg 2013 May-Jun;113(3):228-32. doi: 10.1080/00015458.2013.11680918. PMID: 24941723
Multicenter VATS experience with mediastinal tumors.
Demmy TL, Krasna MJ, Detterbeck FC, Kline GG, Kohman LJ, DeCamp MM Jr, Wain JC
Ann Thorac Surg 1998 Jul;66(1):187-92. doi: 10.1016/s0003-4975(98)00378-6. PMID: 9692462

Prognosis

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Cervical ganglioneuroma: A case report and review of the literature.
Xu T, Zhu W, Wang P
Medicine (Baltimore) 2019 Apr;98(15):e15203. doi: 10.1097/MD.0000000000015203. PMID: 30985715Free PMC Article
Mediastinal (Epipericardial) Fat Necrosis: An Overlooked and Little Known Cause of Acute Chest Pain Mimicking Acute Coronary Syndrome.
Gayer G
Semin Ultrasound CT MR 2017 Dec;38(6):629-633. Epub 2017 Aug 31 doi: 10.1053/j.sult.2017.08.003. PMID: 29179902
Thymoma: radiologic-pathologic correlation.
Rosado-de-Christenson ML, Galobardes J, Moran CA
Radiographics 1992 Jan;12(1):151-68. doi: 10.1148/radiographics.12.1.1734461. PMID: 1734461

Clinical prediction guides

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Fat Content Quantification Using Dual-Energy CT for Differentiation of Anterior Mediastinal Lesions from Normal or Hyperplastic Thymus.
Araki T, Hammer M, Sodickson A
Curr Probl Diagn Radiol 2022 May-Jun;51(3):334-339. Epub 2021 Jul 15 doi: 10.1067/j.cpradiol.2021.06.007. PMID: 34364734
Cervical ganglioneuroma: A case report and review of the literature.
Xu T, Zhu W, Wang P
Medicine (Baltimore) 2019 Apr;98(15):e15203. doi: 10.1097/MD.0000000000015203. PMID: 30985715Free PMC Article
Paravertebral tumours of the cervicothoracic junction extending into the mediastinum: surgical strategies in a no man's land.
Prezerakos GK, Sayal P, Kourliouros A, Pericleous P, Ladas G, Casey A
Eur Spine J 2018 Apr;27(4):902-912. Epub 2018 Feb 14 doi: 10.1007/s00586-018-5512-5. PMID: 29445946
Mediastinal (Epipericardial) Fat Necrosis: An Overlooked and Little Known Cause of Acute Chest Pain Mimicking Acute Coronary Syndrome.
Gayer G
Semin Ultrasound CT MR 2017 Dec;38(6):629-633. Epub 2017 Aug 31 doi: 10.1053/j.sult.2017.08.003. PMID: 29179902

Recent systematic reviews

The role of positron emission tomography using carbon-11 and fluorine-18 choline in tumors other than prostate cancer: a systematic review.
Treglia G, Giovannini E, Di Franco D, Calcagni ML, Rufini V, Picchio M, Giordano A
Ann Nucl Med 2012 Jul;26(6):451-61. Epub 2012 May 8 doi: 10.1007/s12149-012-0602-7. PMID: 22566040

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