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Breast epithelioid hemangioma

MedGen UID:
231965
•Concept ID:
C1332627
•
Neoplastic Process
Synonyms: Breast Epithelioid Hemangioma; breast epithelioid hemangioma; breast histiocytoid hemangioma; Epithelioid Breast Hemangioma; epithelioid breast hemangioma; Epithelioid Hemangioma of Breast; epithelioid hemangioma of breast; Epithelioid Hemangioma of the Breast; epithelioid hemangioma of the breast; histiocytoid breast hemangioma; Histiocytoid Hemangioma of Breast; histiocytoid hemangioma of breast; histiocytoid hemangioma of the breast
 
Monarch Initiative: MONDO:0003897

Definition

A hemangioma that arises from the breast. It is characterized by the presence of epithelioid endothelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast epithelioid hemangioma

Professional guidelines

PubMed

Follow-up outcomes of benign vascular lesions of breast diagnosed on core needle biopsy: A study of 117 cases.
Zhang H, Han M, Varma K, Dabbs DJ
Breast J 2019 May;25(3):401-407. Epub 2019 Apr 18 doi: 10.1111/tbj.13233. PMID: 31001867
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
Liska V, Holubec L Jr, Treska V, Vrzalova J, Skalicky T, Sutnar A, Kormunda S, Bruha J, Vycital O, Finek J, Pesta M, Pecen L, Topolcan O
Anticancer Res 2011 Apr;31(4):1447-51. PMID: 21508401
Diagnosis and treatment of symptomatic breast masses in the pediatric population.
West KW, Rescorla FJ, Scherer LR 3rd, Grosfeld JL
J Pediatr Surg 1995 Feb;30(2):182-6; discussion 186-7. doi: 10.1016/0022-3468(95)90557-x. PMID: 7738735

Recent clinical studies

Etiology

Cavernous Hemangioma Between the Elastomer and Fibrous Capsule of a Breast Implant.
de Mello Tucunduva TC, Gaziero A, Tostes VS, Stiepcich MMA, Torres US, Ohara P, Andrade WP, Ferreira AHPG, Missrie DR, de Mello GGN
Aesthetic Plast Surg 2018 Oct;42(5):1257-1260. Epub 2018 Jun 5 doi: 10.1007/s00266-018-1153-7. PMID: 29872905
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640
Skin metastasis: a pathologist's perspective.
Hussein MR
J Cutan Pathol 2010 Sep;37(9):e1-20. Epub 2009 Nov 17 doi: 10.1111/j.1600-0560.2009.01469.x. PMID: 19922483
MR imaging of breast hemangioma in female infants.
Miaux Y, Lemarchand-Venencie F, Cyna-Gorse F, Frija J, Cohen Y, Dubertret L, Laval-Jeantet M
Pediatr Radiol 1992;22(6):463-4. doi: 10.1007/BF02013514. PMID: 1437377
Cutaneous lymphangioma.
Flanagan BP, Helwig EB
Arch Dermatol 1977 Jan;113(1):24-30. PMID: 831620

Diagnosis

Benign Vascular Lesions of the Breast: A Clinical, Radiographic, and Pathologic Review.
Braun A, Solari M, Gattuso P, Agarwal I
Int J Surg Pathol 2023 Dec;31(8):1437-1448. Epub 2023 Apr 9 doi: 10.1177/10668969231160254. PMID: 37032453
Hemangioma of a Male Breast: Case Report and Review of the Literature.
Yoga A, Lyapichev KA, Baek D, Gomez-Fernandez CR
Am J Case Rep 2018 Nov 30;19:1425-1429. doi: 10.12659/AJCR.911842. PMID: 30498190Free PMC Article
Neoplastic Pericardial Disease.
Maleszewski JJ, Anavekar NS
Cardiol Clin 2017 Nov;35(4):589-600. Epub 2017 Sep 6 doi: 10.1016/j.ccl.2017.07.011. PMID: 29025549
Infantile hemangiomas, complications and treatments.
Cheng CE, Friedlander SF
Semin Cutan Med Surg 2016 Sep;35(3):108-16. doi: 10.12788/j.sder.2016.050. PMID: 27607318
Mesenchymal breast lesions.
Schickman R, Leibman AJ, Handa P, Kornmehl A, Abadi M
Clin Radiol 2015 Jun;70(6):567-75. Epub 2015 Jan 29 doi: 10.1016/j.crad.2014.12.015. PMID: 25638601

Therapy

Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Cavernous Hemangioma Between the Elastomer and Fibrous Capsule of a Breast Implant.
de Mello Tucunduva TC, Gaziero A, Tostes VS, Stiepcich MMA, Torres US, Ohara P, Andrade WP, Ferreira AHPG, Missrie DR, de Mello GGN
Aesthetic Plast Surg 2018 Oct;42(5):1257-1260. Epub 2018 Jun 5 doi: 10.1007/s00266-018-1153-7. PMID: 29872905
Infantile hemangiomas, complications and treatments.
Cheng CE, Friedlander SF
Semin Cutan Med Surg 2016 Sep;35(3):108-16. doi: 10.12788/j.sder.2016.050. PMID: 27607318
Evidence for anti-cancer properties of blueberries: a mini-review.
Johnson SA, Arjmandi BH
Anticancer Agents Med Chem 2013 Oct;13(8):1142-8. doi: 10.2174/18715206113139990137. PMID: 23387969
Skin metastasis: a pathologist's perspective.
Hussein MR
J Cutan Pathol 2010 Sep;37(9):e1-20. Epub 2009 Nov 17 doi: 10.1111/j.1600-0560.2009.01469.x. PMID: 19922483

Prognosis

An extremely rare case of pulmonary epithelioid hemangioendothelioma.
Chen X, Wang Y, Che G, Shen C
Thorac Cancer 2023 Aug;14(24):2519-2522. Epub 2023 Jul 24 doi: 10.1111/1759-7714.15051. PMID: 37488675Free PMC Article
Benign Vascular Lesions of the Breast: A Clinical, Radiographic, and Pathologic Review.
Braun A, Solari M, Gattuso P, Agarwal I
Int J Surg Pathol 2023 Dec;31(8):1437-1448. Epub 2023 Apr 9 doi: 10.1177/10668969231160254. PMID: 37032453
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640
Skin metastasis: a pathologist's perspective.
Hussein MR
J Cutan Pathol 2010 Sep;37(9):e1-20. Epub 2009 Nov 17 doi: 10.1111/j.1600-0560.2009.01469.x. PMID: 19922483
Cutaneous lymphangioma.
Flanagan BP, Helwig EB
Arch Dermatol 1977 Jan;113(1):24-30. PMID: 831620

Clinical prediction guides

Contrast-enhanced ultrasound features of breast capillary hemangioma: a case report and review of literature.
Chou CP, Huang JS, Wang JS, Pan HB
J Ultrasound 2022 Mar;25(1):103-106. Epub 2021 Jan 6 doi: 10.1007/s40477-020-00550-y. PMID: 33409863Free PMC Article
A rare case of pseudomyogenic hemangioendothelioma (PHE)/epithelioid sarcoma-like hemangioendothelioma (ES-H) of the breast first misdiagnosed as metaplastic carcinoma by FNAB and review of the literature.
Ge Y, Lin X, Zhang F, Xu F, Luo L, Huang W, Liu Z, Liu Y, Li Z
Diagn Pathol 2019 Jul 17;14(1):79. doi: 10.1186/s13000-019-0857-6. PMID: 31311568Free PMC Article
Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Hemangioma of a Male Breast: Case Report and Review of the Literature.
Yoga A, Lyapichev KA, Baek D, Gomez-Fernandez CR
Am J Case Rep 2018 Nov 30;19:1425-1429. doi: 10.12659/AJCR.911842. PMID: 30498190Free PMC Article
Skin metastasis: a pathologist's perspective.
Hussein MR
J Cutan Pathol 2010 Sep;37(9):e1-20. Epub 2009 Nov 17 doi: 10.1111/j.1600-0560.2009.01469.x. PMID: 19922483

Recent systematic reviews

Efficacy and safety of adrenergic beta-antagonist combined with lasers in the treatment of infantile hemangiomas: a meta-analysis.
Chen X, Guo Y, Wang P, Qiu F, Sun Y, Shi Q, Deng Y, Hu C, Lei S
Pediatr Surg Int 2020 Oct;36(10):1135-1147. Epub 2020 Jul 9 doi: 10.1007/s00383-020-04711-2. PMID: 32647928

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