U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

MedGen UID:
231973
•Concept ID:
C1332643
•
Neoplastic Process
Synonyms: Burkitt Lymphoma PTLD; Burkitt's Lymphoma Post-Transplant Lymphoproliferative Disorder; Burkitt's Lymphoma PTLD

Definition

A Burkitt lymphoma that arises in a patient with a history of organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBurkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Burkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.
Afify Z, Orjuela-Grimm M, Smith CM, Dalal M, Ford JB, Pillai P, Robles JM, Reddy S, McCormack S, Ehrhardt MJ, Ureda T, Alperstein W, Edington H, Miller TP, Rubinstein JD, Kavanaugh M, Bukowinski AJ, Friehling E, Rivers JM, Chisholm KM, Marks LJ, Mason CC
Br J Haematol 2023 Feb;200(3):297-305. Epub 2022 Dec 1 doi: 10.1111/bjh.18498. PMID: 36454546
Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F
Pediatr Transplant 2009 Feb;13(1):54-62. Epub 2008 Jun 1 doi: 10.1111/j.1399-3046.2008.00969.x. PMID: 18518912
Treatment options for post-transplant lymphoproliferative disorder and other Epstein-Barr virus-associated malignancies.
Davis JE, Moss DJ
Tissue Antigens 2004 Apr;63(4):285-92. doi: 10.1111/j.0001-2815.2004.00227.x. PMID: 15009802

Recent clinical studies

Etiology

B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis.
Capello D, Rossi D, Gaidano G
Hematol Oncol 2005 Jun;23(2):61-7. doi: 10.1002/hon.751. PMID: 16216037
Immunosurveillance, immunodeficiency and lymphoproliferations.
Oertel SH, Riess H
Recent Results Cancer Res 2002;159:1-8. doi: 10.1007/978-3-642-56352-2_1. PMID: 11785833

Diagnosis

B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency.
Low LK, Song JY
Surg Pathol Clin 2016 Mar;9(1):55-77. doi: 10.1016/j.path.2015.10.003. PMID: 26940268
Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder.
Picarsic J, Jaffe R, Mazariegos G, Webber SA, Ellis D, Green MD, Reyes-Múgica M
Cancer 2011 Oct 1;117(19):4540-50. Epub 2011 Mar 28 doi: 10.1002/cncr.26001. PMID: 21446044
Epstein-Barr virus-associated lymphoproliferative disorders.
Ambinder RF
Rev Clin Exp Hematol 2003 Dec;7(4):362-74. PMID: 15129648

Therapy

Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder.
Picarsic J, Jaffe R, Mazariegos G, Webber SA, Ellis D, Green MD, Reyes-Múgica M
Cancer 2011 Oct 1;117(19):4540-50. Epub 2011 Mar 28 doi: 10.1002/cncr.26001. PMID: 21446044
Immunotherapy for Epstein-Barr virus-associated malignancies.
Long HM, Parsonage G, Fox CP, Lee SP
Drug News Perspect 2010 May;23(4):221-8. doi: 10.1358/dnp.2010.23.4.1439500. PMID: 20520851
Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis.
Capello D, Rossi D, Gaidano G
Hematol Oncol 2005 Jun;23(2):61-7. doi: 10.1002/hon.751. PMID: 16216037

Prognosis

B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency.
Low LK, Song JY
Surg Pathol Clin 2016 Mar;9(1):55-77. doi: 10.1016/j.path.2015.10.003. PMID: 26940268
Conservative management of post-transplant central nervous system lymphoma.
Valavoor SH, Ashraf Z, Narwal R, Ratnam S
Int Urol Nephrol 2013 Aug;45(4):1219-22. Epub 2012 Apr 3 doi: 10.1007/s11255-012-0146-8. PMID: 22476860
Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder.
Picarsic J, Jaffe R, Mazariegos G, Webber SA, Ellis D, Green MD, Reyes-Múgica M
Cancer 2011 Oct 1;117(19):4540-50. Epub 2011 Mar 28 doi: 10.1002/cncr.26001. PMID: 21446044
Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F
Pediatr Transplant 2009 Feb;13(1):54-62. Epub 2008 Jun 1 doi: 10.1111/j.1399-3046.2008.00969.x. PMID: 18518912
Post-transplant Burkitt's leukemia or lymphoma. Study of five cases treated with specific intensive therapy (PETHEMA ALL-3/97 trial).
Xicoy B, Ribera JM, Esteve J, Brunet S, Sanz MA, Fernández-Abellán P, Feliu E
Leuk Lymphoma 2003 Sep;44(9):1541-3. doi: 10.3109/10428190309178777. PMID: 14565657

Clinical prediction guides

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
McIntosh MT, Koganti S, Boatwright JL, Li X, Spadaro SV, Brantly AC, Ayers JB, Perez RD, Burton EM, Burgula S, MacCarthy T, Bhaduri-McIntosh S
PLoS Pathog 2020 Oct;16(10):e1008849. Epub 2020 Oct 1 doi: 10.1371/journal.ppat.1008849. PMID: 33002095Free PMC Article
Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.
Öztürk H, Ekşi Bozbulut N, Sarı S, Eğritaş Gürkan Ö, Sözen H, Sapmaz A, Dalgıç A, Dalgıç B
Exp Clin Transplant 2019 Jan;17(Suppl 1):230-233. doi: 10.6002/ect.MESOT2018.P81. PMID: 30777562
Adoptive therapy for EBV-induced cancers: driving success with post-transplant lymphoproliferative disorder to other EBV-derived tumors.
Smith C, Khanna R
Immunotherapy 2015;7(5):563-72. doi: 10.2217/imt.15.7. PMID: 26065480
Risk of lymphoma subtypes after solid organ transplantation in the United States.
Clarke CA, Morton LM, Lynch C, Pfeiffer RM, Hall EC, Gibson TM, Weisenburger DD, Martínez-Maza O, Hussain SK, Yang J, Chang ET, Engels EA
Br J Cancer 2013 Jul 9;109(1):280-8. Epub 2013 Jun 11 doi: 10.1038/bjc.2013.294. PMID: 23756857Free PMC Article
Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel SH, Verschuuren E, Reinke P, Zeidler K, Papp-Váry M, Babel N, Trappe RU, Jonas S, Hummel M, Anagnostopoulos I, Dörken B, Riess HB
Am J Transplant 2005 Dec;5(12):2901-6. doi: 10.1111/j.1600-6143.2005.01098.x. PMID: 16303003

Recent systematic reviews

CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.
Portuguese AJ, Gauthier J, Tykodi SS, Hall ET, Hirayama AV, Yeung CCS, Blosser CD
Bone Marrow Transplant 2023 Apr;58(4):353-359. Epub 2022 Dec 27 doi: 10.1038/s41409-022-01907-z. PMID: 36575360

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...