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Pediatric mesenchymal chondrosarcoma

MedGen UID:
232063
•Concept ID:
C1332982
•
Neoplastic Process
Synonyms: Childhood Mesenchymal Chondrosarcoma; childhood mesenchymal chondrosarcoma; mesenchymal chondrosarcoma of childhood; Pediatric Mesenchymal Chondrosarcoma; pediatric mesenchymal chondrosarcoma
 
Monarch Initiative: MONDO:0003041

Definition

A rare mesenchymal chondrosarcoma that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric mesenchymal chondrosarcoma

Professional guidelines

PubMed

Proton radiotherapy in management of pediatric base of skull tumors.
Hug EB, Sweeney RA, Nurre PM, Holloway KC, Slater JD, Munzenrider JE
Int J Radiat Oncol Biol Phys 2002 Mar 15;52(4):1017-24. doi: 10.1016/s0360-3016(01)02725-0. PMID: 11958897

Recent clinical studies

Etiology

Real-world experience of tyrosine kinase inhibitors in children, adolescents and adults with relapsed or refractory bone tumours: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) study.
Peretz Soroka H, Vora T, Noujaim J, Marcoux N, Cohen-Gogo S, Alcindor T, Holloway C, Rodrigues C, Karachiwala H, Alvi S, Lee U, Cheng S, Banerji S, Oberoi S, Feng X, Smrke A, Simmons C, Razak AA, Gupta AA
Cancer Med 2023 Sep;12(18):18872-18881. Epub 2023 Sep 19 doi: 10.1002/cam4.6515. PMID: 37724607Free PMC Article
The Small Round Cell Sarcomas Complexities and Desmoplastic Presentation.
Domanski HA
Acta Cytol 2022;66(4):279-294. Epub 2022 Apr 13 doi: 10.1159/000524260. PMID: 35417916Free PMC Article
Mesenchymal Chondrosarcoma-A Retrospective study.
Beena D, Kattoor J, Mathews A, P Nair S, M V, T P, N G
Gulf J Oncolog 2021 Jan;1(35):54-58. PMID: 33716213
Sarcoma Stem Cell Heterogeneity.
Hatina J, Kripnerova M, Houfkova K, Pesta M, Kuncova J, Sana J, Slaby O, Rodríguez R
Adv Exp Med Biol 2019;1123:95-118. doi: 10.1007/978-3-030-11096-3_7. PMID: 31016597
Intraspinal mesenchymal chondrosarcoma: report of a pediatric case and literature review.
Di Giannatale A, Colletti M, Russo I, Ferruzzi V, Dell' Anna VA, Cozza R, Colafati GS, Messina R, Mastronuzzi A, De Vito R, Milano GM
Tumori 2017 Nov 15;103(Suppl. 1):e66-e72. doi: 10.5301/tj.5000689. PMID: 29143958

Diagnosis

Molecular imaging of sarcomas with FDG PET.
Mendoza H, Nosov A, Pandit-Taskar N
Skeletal Radiol 2023 Mar;52(3):461-475. Epub 2022 Sep 29 doi: 10.1007/s00256-022-04182-7. PMID: 36173459
The Small Round Cell Sarcomas Complexities and Desmoplastic Presentation.
Domanski HA
Acta Cytol 2022;66(4):279-294. Epub 2022 Apr 13 doi: 10.1159/000524260. PMID: 35417916Free PMC Article
Mesenchymal Chondrosarcoma-A Retrospective study.
Beena D, Kattoor J, Mathews A, P Nair S, M V, T P, N G
Gulf J Oncolog 2021 Jan;1(35):54-58. PMID: 33716213
The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis.
Kovar H, Bierbaumer L, Radic-Sarikas B
Cells 2020 Apr 15;9(4) doi: 10.3390/cells9040972. PMID: 32326412Free PMC Article
Primary intradural extramedullary spinal mesenchymal chondrosarcoma: case report and literature review.
Chen CW, Chen IH, Hu MH, Lee JC, Huang HY, Hong RL, Yang SH
BMC Musculoskelet Disord 2019 Sep 4;20(1):408. doi: 10.1186/s12891-019-2799-2. PMID: 31484514Free PMC Article

Therapy

Primary alveolar rhabdomyosarcoma of the bone: two cases and review of the literature.
Balogh P, Bánusz R, Csóka M, Váradi Z, Varga E, Sápi Z
Diagn Pathol 2016 Oct 18;11(1):99. doi: 10.1186/s13000-016-0552-9. PMID: 27756397Free PMC Article
Sacral mesenchymal chondrosarcoma in childhood: a case report and review of the literature.
Küpeli S, Varan A, Gedikoğlu G, Büyükpamukçu M
Pediatr Hematol Oncol 2010 Oct;27(7):564-73. doi: 10.3109/08880018.2010.503333. PMID: 20677924
Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups.
Dantonello TM, Int-Veen C, Leuschner I, Schuck A, Furtwaengler R, Claviez A, Schneider DT, Klingebiel T, Bielack SS, Koscielniak E; CWS study group; COSS study group
Cancer 2008 Jun;112(11):2424-31. doi: 10.1002/cncr.23457. PMID: 18438777
Central nervous system involvement in children with sarcoma.
Postovsky S, Ash S, Ramu IN, Yaniv Y, Zaizov R, Futerman B, Elhasid R, Ben Barak A, Halil A, Ben Arush MW
Oncology 2003;65(2):118-24. doi: 10.1159/000072336. PMID: 12931017
Proton radiotherapy in management of pediatric base of skull tumors.
Hug EB, Sweeney RA, Nurre PM, Holloway KC, Slater JD, Munzenrider JE
Int J Radiat Oncol Biol Phys 2002 Mar 15;52(4):1017-24. doi: 10.1016/s0360-3016(01)02725-0. PMID: 11958897

Prognosis

Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness.
Chang TY, Lan KC, Wu CH, Sheu ML, Yang RS, Liu SH
Arch Toxicol 2023 Aug;97(8):2231-2244. Epub 2023 Jun 14 doi: 10.1007/s00204-023-03539-8. PMID: 37314482
Molecular imaging of sarcomas with FDG PET.
Mendoza H, Nosov A, Pandit-Taskar N
Skeletal Radiol 2023 Mar;52(3):461-475. Epub 2022 Sep 29 doi: 10.1007/s00256-022-04182-7. PMID: 36173459
Intraspinal mesenchymal chondrosarcoma: report of a pediatric case and literature review.
Di Giannatale A, Colletti M, Russo I, Ferruzzi V, Dell' Anna VA, Cozza R, Colafati GS, Messina R, Mastronuzzi A, De Vito R, Milano GM
Tumori 2017 Nov 15;103(Suppl. 1):e66-e72. doi: 10.5301/tj.5000689. PMID: 29143958
Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups.
Dantonello TM, Int-Veen C, Leuschner I, Schuck A, Furtwaengler R, Claviez A, Schneider DT, Klingebiel T, Bielack SS, Koscielniak E; CWS study group; COSS study group
Cancer 2008 Jun;112(11):2424-31. doi: 10.1002/cncr.23457. PMID: 18438777
Primary chondrosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 14 cases with a review of the literature.
Gadwal SR, Fanburg-Smith JC, Gannon FH, Thompson LD
Cancer 2000 May 1;88(9):2181-8. PMID: 10813732

Clinical prediction guides

Molecular imaging of sarcomas with FDG PET.
Mendoza H, Nosov A, Pandit-Taskar N
Skeletal Radiol 2023 Mar;52(3):461-475. Epub 2022 Sep 29 doi: 10.1007/s00256-022-04182-7. PMID: 36173459
Paediatric High-Grade Intracranial Mesenchymal Chondrosarcoma: A Case Report with 6 Years of Follow-Up without Recurrence.
Afşer KA, İştemen İ, Arslan A, Ökten AI
Pediatr Neurosurg 2020;55(5):299-303. Epub 2020 Nov 5 doi: 10.1159/000511021. PMID: 33152731
Primary alveolar rhabdomyosarcoma of the bone: two cases and review of the literature.
Balogh P, Bánusz R, Csóka M, Váradi Z, Varga E, Sápi Z
Diagn Pathol 2016 Oct 18;11(1):99. doi: 10.1186/s13000-016-0552-9. PMID: 27756397Free PMC Article
Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups.
Dantonello TM, Int-Veen C, Leuschner I, Schuck A, Furtwaengler R, Claviez A, Schneider DT, Klingebiel T, Bielack SS, Koscielniak E; CWS study group; COSS study group
Cancer 2008 Jun;112(11):2424-31. doi: 10.1002/cncr.23457. PMID: 18438777
Proton radiotherapy in management of pediatric base of skull tumors.
Hug EB, Sweeney RA, Nurre PM, Holloway KC, Slater JD, Munzenrider JE
Int J Radiat Oncol Biol Phys 2002 Mar 15;52(4):1017-24. doi: 10.1016/s0360-3016(01)02725-0. PMID: 11958897

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