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Colloid carcinoma of the pancreas

MedGen UID:
232082
•Concept ID:
C1333081
•
Neoplastic Process
Synonyms: colloid carcinoma of the pancreas; Mucinous Noncystic Carcinoma; mucinous Noncystic carcinoma; Pancreatic Colloid Carcinoma; Pancreatic Mucinous Noncystic Carcinoma; pancreatic mucinous Noncystic carcinoma
 
Monarch Initiative: MONDO:0004341

Definition

An infiltrating pancreatic ductal adenocarcinoma, characterized by the presence of malignant cells floating in pools of mucin. It has a more favorable prognosis than the conventional infiltrating ductal adenocarcinoma. It often arises in association with intraductal pancreatic mucinous neoplasms and in some cases it may result in the development of pseudomyxoma peritonei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColloid carcinoma of the pancreas

Professional guidelines

PubMed

The Role of Perioperative Chemotherapy in the Management of Colloid Carcinoma of the Pancreas.
Picado O, Dosch AR, Garcia-Buitrago MT, Yakoub D, Dudeja V, Rodgers SE
Pancreas 2021 Mar 1;50(3):306-312. doi: 10.1097/MPA.0000000000001787. PMID: 33835960

Recent clinical studies

Etiology

The Landmark Series: Intraductal Papillary Mucinous Neoplasms of the Pancreas-From Prevalence to Early Cancer Detection.
Pollini T, Wong P, Maker AV
Ann Surg Oncol 2023 Mar;30(3):1453-1462. Epub 2023 Jan 4 doi: 10.1245/s10434-022-12870-w. PMID: 36600097Free PMC Article
The Role of Perioperative Chemotherapy in the Management of Colloid Carcinoma of the Pancreas.
Picado O, Dosch AR, Garcia-Buitrago MT, Yakoub D, Dudeja V, Rodgers SE
Pancreas 2021 Mar 1;50(3):306-312. doi: 10.1097/MPA.0000000000001787. PMID: 33835960
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Approach to cystic lesions of the pancreas.
Schmid RM, Siveke JT
Wien Med Wochenschr 2014 Feb;164(3-4):44-50. Epub 2013 Nov 20 doi: 10.1007/s10354-013-0244-y. PMID: 24254128
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775

Diagnosis

The Landmark Series: Intraductal Papillary Mucinous Neoplasms of the Pancreas-From Prevalence to Early Cancer Detection.
Pollini T, Wong P, Maker AV
Ann Surg Oncol 2023 Mar;30(3):1453-1462. Epub 2023 Jan 4 doi: 10.1245/s10434-022-12870-w. PMID: 36600097Free PMC Article
The application of single-cell sequencing in pancreatic neoplasm: analysis, diagnosis and treatment.
Lv G, Zhang L, Gao L, Cui J, Liu Z, Sun B, Wang G, Tang Q
Br J Cancer 2023 Jan;128(2):206-218. Epub 2022 Oct 28 doi: 10.1038/s41416-022-02023-x. PMID: 36307645Free PMC Article
Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Approach to cystic lesions of the pancreas.
Schmid RM, Siveke JT
Wien Med Wochenschr 2014 Feb;164(3-4):44-50. Epub 2013 Nov 20 doi: 10.1007/s10354-013-0244-y. PMID: 24254128
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775

Therapy

Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.
Ooka K, Rustagi T, Evans A, Farrell JJ
Pancreas 2017 Aug;46(7):927-935. doi: 10.1097/MPA.0000000000000858. PMID: 28697134
Peroral cholangiopancreatoscopy with the SpyGlass® system: what do we know 10 years later.
Pereira P, Peixoto A, Andrade P, Macedo G
J Gastrointestin Liver Dis 2017 Jun;26(2):165-170. doi: 10.15403/jgld.2014.1121.262.cho. PMID: 28617887
The Sendai and Fukuoka consensus criteria for the management of branch duct IPMN - A meta-analysis on their accuracy.
Heckler M, Michalski CW, Schaefle S, Kaiser J, Büchler MW, Hackert T
Pancreatology 2017 Mar-Apr;17(2):255-262. Epub 2017 Feb 1 doi: 10.1016/j.pan.2017.01.011. PMID: 28189431
Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity.
Assifi MM, Nguyen PD, Agrawal N, Dedania N, Kennedy EP, Sauter PK, Prestipino A, Winter JM, Yeo CJ, Lavu H
J Gastrointest Surg 2014 Mar;18(3):523-31. Epub 2014 Jan 22 doi: 10.1007/s11605-014-2459-7. PMID: 24449000

Prognosis

Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma.
Zhao X, Li H, Lyu S, Zhai J, Ji Z, Zhang Z, Zhang X, Liu Z, Wang H, Xu J, Fan H, Kou J, Li L, Lang R, He Q
Int J Biol Sci 2021;17(10):2590-2605. Epub 2021 Jun 22 doi: 10.7150/ijbs.58886. PMID: 34326696Free PMC Article
The Role of Perioperative Chemotherapy in the Management of Colloid Carcinoma of the Pancreas.
Picado O, Dosch AR, Garcia-Buitrago MT, Yakoub D, Dudeja V, Rodgers SE
Pancreas 2021 Mar 1;50(3):306-312. doi: 10.1097/MPA.0000000000001787. PMID: 33835960
Cells of origin of pancreatic neoplasms.
Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M
Surg Today 2018 Jan;48(1):9-17. Epub 2017 Mar 4 doi: 10.1007/s00595-017-1501-2. PMID: 28260136
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775

Clinical prediction guides

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Age-related morphological changes in the pancreas and their association with pancreatic carcinogenesis.
Matsuda Y
Pathol Int 2019 Aug;69(8):450-462. Epub 2019 Jul 24 doi: 10.1111/pin.12837. PMID: 31339204
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Patient Selection for Cytoreductive Surgery.
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article

Recent systematic reviews

Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors.
Paolino G, Esposito I, Hong SM, Basturk O, Mattiolo P, Kaneko T, Veronese N, Scarpa A, Adsay V, Luchini C
Histopathology 2022 Sep;81(3):297-309. Epub 2022 May 27 doi: 10.1111/his.14698. PMID: 35583805Free PMC Article
Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Pancreatic Neuroendocrine Tumors and Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review.
Manuel-Vazquez A, Ramia JM, Latorre-Fragua R, Valle-Rubio A, Arteaga-Peralta V, Ramiro-Pérez C, de la Plaza-Llamas R
Pancreas 2018 May/Jun;47(5):551-555. doi: 10.1097/MPA.0000000000001048. PMID: 29683974
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.
Ooka K, Rustagi T, Evans A, Farrell JJ
Pancreas 2017 Aug;46(7):927-935. doi: 10.1097/MPA.0000000000000858. PMID: 28697134
Progression of Unresected Intraductal Papillary Mucinous Neoplasms of the Pancreas to Cancer: A Systematic Review and Meta-analysis.
Choi SH, Park SH, Kim KW, Lee JY, Lee SS
Clin Gastroenterol Hepatol 2017 Oct;15(10):1509-1520.e4. Epub 2017 Mar 22 doi: 10.1016/j.cgh.2017.03.020. PMID: 28342950

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