U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Colloid carcinoma of the pancreas

MedGen UID:
232082
•Concept ID:
C1333081
•
Neoplastic Process
Synonyms: colloid carcinoma of the pancreas; Mucinous Noncystic Carcinoma; mucinous Noncystic carcinoma; Pancreatic Colloid Carcinoma; Pancreatic Mucinous Noncystic Carcinoma; pancreatic mucinous Noncystic carcinoma
 
Monarch Initiative: MONDO:0004341

Definition

An infiltrating pancreatic ductal adenocarcinoma, characterized by the presence of malignant cells floating in pools of mucin. It has a more favorable prognosis than the conventional infiltrating ductal adenocarcinoma. It often arises in association with intraductal pancreatic mucinous neoplasms and in some cases it may result in the development of pseudomyxoma peritonei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColloid carcinoma of the pancreas

Professional guidelines

PubMed

The Role of Perioperative Chemotherapy in the Management of Colloid Carcinoma of the Pancreas.
Picado O, Dosch AR, Garcia-Buitrago MT, Yakoub D, Dudeja V, Rodgers SE
Pancreas 2021 Mar 1;50(3):306-312. doi: 10.1097/MPA.0000000000001787. PMID: 33835960

Recent clinical studies

Etiology

Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Uptodate in the assessment and management of intraductal papillary mucinous neoplasms of the pancreas.
Pagliari D, Saviano A, Serricchio ML, Dal Lago AA, Brizi MG, Lanza F, Manfredi R, Gasbarrini A, Attili F
Eur Rev Med Pharmacol Sci 2017 Jun;21(12):2858-2874. PMID: 28682431
Intraductal papillary mucinous neoplasms of the pancreas: reporting clinically relevant features.
Del Chiaro M, Verbeke C
Histopathology 2017 May;70(6):850-860. Epub 2017 Jan 15 doi: 10.1111/his.13131. PMID: 27878841
Intraductal papillary mucinous neoplasms.
Sahora K, Fernández-del Castillo C
Curr Opin Gastroenterol 2015 Sep;31(5):424-9. doi: 10.1097/MOG.0000000000000198. PMID: 26125316
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775

Diagnosis

Static and Dynamic (68)Ga-FAPI PET/CT for the Detection of Malignant Transformation of Intraductal Papillary Mucinous Neoplasia of the Pancreas.
Lang M, Spektor AM, Hielscher T, Hoppner J, Glatting FM, Bicu F, Hackert T, Heger U, Pausch T, Gutjahr E, Rathke H, Giesel FL, Kratochwil C, Tjaden C, Haberkorn U, Röhrich M
J Nucl Med 2023 Feb;64(2):244-251. Epub 2022 Jul 29 doi: 10.2967/jnumed.122.264361. PMID: 35906094Free PMC Article
Intraductal papillary mucinous neoplasm of the pancreas: Cytomorphology, imaging, molecular profile, and prognosis.
Geramizadeh B, Marzban M, Shojazadeh A, Kadivar A, Maleki Z
Cytopathology 2021 Jul;32(4):397-406. Epub 2021 Apr 1 doi: 10.1111/cyt.12973. PMID: 33792980
Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775
Pancreatic cystic neoplasms.
Verbesey JE, Munson JL
Surg Clin North Am 2010 Apr;90(2):411-25. doi: 10.1016/j.suc.2009.12.006. PMID: 20362795

Therapy

Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer.
Alva-Ruiz R, Yohanathan L, Yonkus JA, Abdelrahman AM, Gregory LA, Halfdanarson TR, Mahipal A, McWilliams RR, Ma WW, Hallemeier CL, Graham RP, Grotz TE, Smoot RL, Cleary SP, Nagorney DM, Kendrick ML, Truty MJ
Ann Surg Oncol 2022 Mar;29(3):1579-1591. Epub 2021 Nov 1 doi: 10.1245/s10434-021-10991-2. PMID: 34724125Free PMC Article
Molecular and clinical patterns of local progression in the pancreatic remnant following resection of pancreatic intraductal papillary mucinous neoplasm (IPMN).
Sereni E, Luchini C, Salvia R, Pea A
Chin Clin Oncol 2019 Apr;8(2):21. doi: 10.21037/cco.2019.04.03. PMID: 31070041
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
The Sendai and Fukuoka consensus criteria for the management of branch duct IPMN - A meta-analysis on their accuracy.
Heckler M, Michalski CW, Schaefle S, Kaiser J, Büchler MW, Hackert T
Pancreatology 2017 Mar-Apr;17(2):255-262. Epub 2017 Feb 1 doi: 10.1016/j.pan.2017.01.011. PMID: 28189431
Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity.
Assifi MM, Nguyen PD, Agrawal N, Dedania N, Kennedy EP, Sauter PK, Prestipino A, Winter JM, Yeo CJ, Lavu H
J Gastrointest Surg 2014 Mar;18(3):523-31. Epub 2014 Jan 22 doi: 10.1007/s11605-014-2459-7. PMID: 24449000

Prognosis

Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma.
Zhao X, Li H, Lyu S, Zhai J, Ji Z, Zhang Z, Zhang X, Liu Z, Wang H, Xu J, Fan H, Kou J, Li L, Lang R, He Q
Int J Biol Sci 2021;17(10):2590-2605. Epub 2021 Jun 22 doi: 10.7150/ijbs.58886. PMID: 34326696Free PMC Article
Intraductal papillary mucinous neoplasm of the pancreas: Cytomorphology, imaging, molecular profile, and prognosis.
Geramizadeh B, Marzban M, Shojazadeh A, Kadivar A, Maleki Z
Cytopathology 2021 Jul;32(4):397-406. Epub 2021 Apr 1 doi: 10.1111/cyt.12973. PMID: 33792980
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Intraductal papillary mucinous neoplasms.
Sahora K, Fernández-del Castillo C
Curr Opin Gastroenterol 2015 Sep;31(5):424-9. doi: 10.1097/MOG.0000000000000198. PMID: 26125316
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775

Clinical prediction guides

Intraductal papillary mucinous neoplasm of the pancreas: Cytomorphology, imaging, molecular profile, and prognosis.
Geramizadeh B, Marzban M, Shojazadeh A, Kadivar A, Maleki Z
Cytopathology 2021 Jul;32(4):397-406. Epub 2021 Apr 1 doi: 10.1111/cyt.12973. PMID: 33792980
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Age-related morphological changes in the pancreas and their association with pancreatic carcinogenesis.
Matsuda Y
Pathol Int 2019 Aug;69(8):450-462. Epub 2019 Jul 24 doi: 10.1111/pin.12837. PMID: 31339204
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Intraductal papillary mucinous neoplasms.
Sahora K, Fernández-del Castillo C
Curr Opin Gastroenterol 2015 Sep;31(5):424-9. doi: 10.1097/MOG.0000000000000198. PMID: 26125316

Recent systematic reviews

Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors.
Paolino G, Esposito I, Hong SM, Basturk O, Mattiolo P, Kaneko T, Veronese N, Scarpa A, Adsay V, Luchini C
Histopathology 2022 Sep;81(3):297-309. Epub 2022 May 27 doi: 10.1111/his.14698. PMID: 35583805Free PMC Article
Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Pancreatic Neuroendocrine Tumors and Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review.
Manuel-Vazquez A, Ramia JM, Latorre-Fragua R, Valle-Rubio A, Arteaga-Peralta V, Ramiro-Pérez C, de la Plaza-Llamas R
Pancreas 2018 May/Jun;47(5):551-555. doi: 10.1097/MPA.0000000000001048. PMID: 29683974
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.
Ooka K, Rustagi T, Evans A, Farrell JJ
Pancreas 2017 Aug;46(7):927-935. doi: 10.1097/MPA.0000000000000858. PMID: 28697134
Progression of Unresected Intraductal Papillary Mucinous Neoplasms of the Pancreas to Cancer: A Systematic Review and Meta-analysis.
Choi SH, Park SH, Kim KW, Lee JY, Lee SS
Clin Gastroenterol Hepatol 2017 Oct;15(10):1509-1520.e4. Epub 2017 Mar 22 doi: 10.1016/j.cgh.2017.03.020. PMID: 28342950

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...