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Desmoplastic melanoma

MedGen UID:
232127
•Concept ID:
C1333280
•
Neoplastic Process
Synonyms: desmoplastic cutaneous (skin) melanoma; Desmoplastic Melanoma; desmoplastic melanoma
 
Monarch Initiative: MONDO:0044785

Definition

A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDesmoplastic melanoma

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
The changing landscape in management of desmoplastic melanoma.
Dunne JA, Adigbli G
J Surg Oncol 2022 Feb;125(2):227-228. Epub 2021 Sep 17 doi: 10.1002/jso.26677. PMID: 34535908
Do Not Forget About the Importance of Loco-Regional Therapy in Melanoma Management.
Wuthrick EJ, Chablani P
Semin Radiat Oncol 2019 Apr;29(2):166-170. doi: 10.1016/j.semradonc.2018.11.006. PMID: 30827455

Recent clinical studies

Etiology

Desmoplastic melanoma: a review of its pathology and clinical behaviour, and of management recommendations in published guidelines.
Hughes TM, Williams GJ, Gyorki DE, Kelly JW, Stretch JR, Varey AHR, Hong AM, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2021 Jun;35(6):1290-1298. Epub 2021 Mar 3 doi: 10.1111/jdv.17154. PMID: 33544941
Desmoplastic melanoma: a brief review and the efficacy of immunotherapy.
Ochoa CE, Joseph RW
Expert Rev Anticancer Ther 2019 Mar;19(3):205-207. Epub 2019 Feb 4 doi: 10.1080/14737140.2019.1574573. PMID: 30686076
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Desmoplastic melanoma, neurotropism, and neurotrophin receptors--what we know and what we do not.
Frydenlund N, Mahalingam M
Adv Anat Pathol 2015 Jul;22(4):227-41. doi: 10.1097/PAP.0000000000000076. PMID: 26050260
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

Diagnosis

Dermatoscopy of melanoma according to type, anatomic site and stage.
Lallas A, Paschou E, Manoli SM, Papageorgiou C, Spyridis I, Liopyris K, Bobos M, Moutsoudis A, Lazaridou E, Apalla Z
Ital J Dermatol Venerol 2021 Jun;156(3):274-288. Epub 2020 Dec 14 doi: 10.23736/S2784-8671.20.06784-X. PMID: 33314891
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Therapy

The changing landscape in management of desmoplastic melanoma.
Dunne JA, Adigbli G
J Surg Oncol 2022 Feb;125(2):227-228. Epub 2021 Sep 17 doi: 10.1002/jso.26677. PMID: 34535908
Differing biologic behaviors of desmoplastic melanoma subtypes: Insights based on histopathologic, immunohistochemical, and genetic analyses.
Yang K, Mahalingam M
J Am Acad Dermatol 2020 Aug;83(2):523-531. Epub 2020 Feb 14 doi: 10.1016/j.jaad.2020.02.014. PMID: 32068045
Melanoma on chronically sun-damaged skin: Lentigo maligna and desmoplastic melanoma.
DeWane ME, Kelsey A, Oliviero M, Rabinovitz H, Grant-Kels JM
J Am Acad Dermatol 2019 Sep;81(3):823-833. Epub 2019 Mar 28 doi: 10.1016/j.jaad.2019.03.066. PMID: 30930085
Do Not Forget About the Importance of Loco-Regional Therapy in Melanoma Management.
Wuthrick EJ, Chablani P
Semin Radiat Oncol 2019 Apr;29(2):166-170. doi: 10.1016/j.semradonc.2018.11.006. PMID: 30827455
Cutaneous desmoplastic melanoma.
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Prognosis

Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Desmoplastic melanoma.
Nicolson NG, Han D
J Surg Oncol 2019 Jan;119(2):208-215. Epub 2018 Nov 27 doi: 10.1002/jso.25317. PMID: 30481377
Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Clinical prediction guides

PRAME Expression Is a Useful Tool in the Diagnosis of Primary and Metastatic Dedifferentiated and Undifferentiated Melanoma.
Hornick JL, Plaza JA, Mentzel T, Gru AA, Brenn T
Am J Surg Pathol 2023 Dec 1;47(12):1390-1397. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002125. PMID: 37727938
Desmoplastic Melanomas Mimicking Neurofibromas.
Gerami P, Kim D, Zhang B, Compres EV, Khan AU, Yazdan P, Guitart J, Busam K
Am J Dermatopathol 2020 Dec;42(12):916-922. doi: 10.1097/DAD.0000000000001754. PMID: 32732692Free PMC Article
Desmoplastic melanoma: a challenge for the oncologist.
Manfredini M, Pellacani G, Losi L, Maccaferri M, Tomasi A, Ponti G
Future Oncol 2017 Feb;13(4):337-345. Epub 2016 Oct 12 doi: 10.2217/fon-2016-0334. PMID: 27728982
The emerging role of radiotherapy for desmoplastic melanoma and implications for future research.
Oliver DE, Patel KR, Parker D, Delman KA, Lawson DH, Kudchadkar RR, Khan MK
Melanoma Res 2015 Apr;25(2):95-102. doi: 10.1097/CMR.0000000000000139. PMID: 25588202
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

Recent systematic reviews

Local Recurrence Rates After Excision of Desmoplastic Melanoma: A Systematic Review and Meta-Analysis.
Ran NA, Veerabagu S, Miller CJ, Elenitsas R, Chu EY, Krausz AE
Dermatol Surg 2023 Apr 1;49(4):330-337. Epub 2023 Mar 1 doi: 10.1097/DSS.0000000000003699. PMID: 36857167
Sentinel lymph node biopsy in desmoplastic melanoma - the percent desmoplastic component matters: A systematic review.
Hodson M, Feustel P, Davis L
J Plast Reconstr Aesthet Surg 2022 Dec;75(12):4441-4449. Epub 2022 Aug 28 doi: 10.1016/j.bjps.2022.08.044. PMID: 36283925
Is sentinel lymph node biopsy warranted for desmoplastic melanoma? A systematic review.
Dunne JA, Wormald JC, Steele J, Woods E, Odili J, Powell BW
J Plast Reconstr Aesthet Surg 2017 Feb;70(2):274-280. Epub 2016 Nov 16 doi: 10.1016/j.bjps.2016.11.003. PMID: 28017261
Rare presentations of primary melanoma and special populations: a systematic review.
Kottschade LA, Grotz TE, Dronca RS, Salomao DR, Pulido JS, Wasif N, Jakub JW, Bagaria SP, Kumar R, Kaur JS, Morita SY, Moran SL, Nguyen JT, Nguyen EC, Hand JL, Erickson LA, Brewer JD, Baum CL, Miller RC, Swanson DL, Lowe V, Markovic SN
Am J Clin Oncol 2014 Dec;37(6):635-41. doi: 10.1097/COC.0b013e3182868e82. PMID: 23563206Free PMC Article
Desmoplastic malignant melanoma: a systematic review.
Lens MB, Newton-Bishop JA, Boon AP
Br J Dermatol 2005 Apr;152(4):673-8. doi: 10.1111/j.1365-2133.2005.06462.x. PMID: 15840097

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