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Ectopic Parathormone Secretion Syndrome

MedGen UID:
232147
•Concept ID:
C1333374
•
Pathologic Function
Synonym: Ectopic Parathormone Secretion

Definition

A syndrome characterized by abnormal secretion of parathyroid hormone in conjunction with neoplastic growth occurring anywhere in the body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic Parathormone Secretion Syndrome

Professional guidelines

PubMed

Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article
Determination of circulating parathyroid hormone levels and differential diagnosis of hypercalcemia.
Rizzoli R, Vadas L, Bonjour JP
Nucl Med Biol 1994 Apr;21(3):337-47. doi: 10.1016/0969-8051(94)90057-4. PMID: 9234299
Diagnosis and treatment of Zollinger-Ellison syndrome.
Mignon M, Bonfils S
Baillieres Clin Gastroenterol 1988 Jul;2(3):677-98. doi: 10.1016/s0950-3528(88)80013-7. PMID: 3048457

Recent clinical studies

Etiology

The pathophysiology of hypophosphatemia.
Ito N, Hidaka N, Kato H
Best Pract Res Clin Endocrinol Metab 2024 Mar;38(2):101851. Epub 2023 Nov 30 doi: 10.1016/j.beem.2023.101851. PMID: 38087658
Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms.
Daskalakis K, Chatzelis E, Tsoli M, Papadopoulou-Marketou N, Dimitriadis GK, Tsolakis AV, Kaltsas G
Endocrine 2019 May;64(2):384-392. Epub 2018 Oct 2 doi: 10.1007/s12020-018-1773-3. PMID: 30280284Free PMC Article
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article
Prognostic factors in ectopic Cushing's syndrome due to neuroendocrine tumors: a multicenter study.
Davi' MV, Cosaro E, Piacentini S, Reimondo G, Albiger N, Arnaldi G, Faggiano A, Mantovani G, Fazio N, Piovesan A, Arvat E, Grimaldi F, Canu L, Mannelli M, Ambrogio AG, Pecori Giraldi F, Martini C, Lania A, Albertelli M, Ferone D, Zatelli MC, Campana D, Colao A, Scaroni C, Terzolo M, De Marinis L, Cingarlini S, Micciolo R, Francia G
Eur J Endocrinol 2017 Apr;176(4):453-461. doi: 10.1530/EJE-16-0809. PMID: 28183788
Hyperplasia in glands with hormone excess.
Marx SJ
Endocr Relat Cancer 2016 Jan;23(1):R1-14. Epub 2015 Sep 25 doi: 10.1530/ERC-15-0171. PMID: 26407873Free PMC Article

Diagnosis

The pathophysiology of hypophosphatemia.
Ito N, Hidaka N, Kato H
Best Pract Res Clin Endocrinol Metab 2024 Mar;38(2):101851. Epub 2023 Nov 30 doi: 10.1016/j.beem.2023.101851. PMID: 38087658
Paraneoplastic syndromes: A focus on pathophysiology and supportive care.
Chung C, Allen E, Umoru G
Am J Health Syst Pharm 2022 Nov 7;79(22):1988-2000. doi: 10.1093/ajhp/zxac211. PMID: 35916756
A clinical perspective of parathyroid hormone related hypercalcaemia.
Han CH, Fry CH, Sharma P, Han TS
Rev Endocr Metab Disord 2020 Mar;21(1):77-88. doi: 10.1007/s11154-019-09529-5. PMID: 31797261Free PMC Article
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article
Ectopic hormone syndromes.
Imura H
Clin Endocrinol Metab 1980 Jul;9(2):235-60. doi: 10.1016/s0300-595x(80)80032-6. PMID: 6105029

Therapy

Efficacy and safety of microwave ablation for ectopic secondary hyperparathyroidism: a feasibility study.
Li X, Wei Y, Shao H, Peng L, An C, Yu MA
Int J Hyperthermia 2019;36(1):647-653. doi: 10.1080/02656736.2019.1627429. PMID: 31305184
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article
Inorganic phosphate homeostasis and the role of dietary phosphorus.
Takeda E, Yamamoto H, Nashiki K, Sato T, Arai H, Taketani Y
J Cell Mol Med 2004 Apr-Jun;8(2):191-200. doi: 10.1111/j.1582-4934.2004.tb00274.x. PMID: 15256067Free PMC Article
Tumor hypercalcemia and "ectopic hyperparathyroidism".
Skrabanek P, McPartlin J, Powell D
Medicine (Baltimore) 1980 Jul;59(4):262-82. doi: 10.1097/00005792-198007000-00003. PMID: 6993843
Ectopic PTH syndrome, pseudohyperparathyroidism; hypercalcaemia of malignancy.
Buckle R
Clin Endocrinol Metab 1974 Jul;3(2):237-51. doi: 10.1016/s0300-595x(74)80008-3. PMID: 4611664

Prognosis

Neuroendocrine Carcinoma of the Endometrium with Ectopic Secretion of Parathyroid Hormone Presenting as Hypercalcemia- Related Posterior Reversible Encephalopathy syndrome: A Case Report.
Lin W, Lin YH, Gao HW, Chen IF, Ko CA, Tsai CK, Lin YK
Acta Neurol Taiwan 2022 Jan 25;31(1):36-40. PMID: 34988952
Incidence of and risk factors for post-parathyroidectomy hungry bone syndrome in patients with secondary hyperparathyroidism.
Kritmetapak K, Kongpetch S, Chotmongkol W, Raruenrom Y, Sangkhamanon S, Pongchaiyakul C
Ren Fail 2020 Nov;42(1):1118-1126. doi: 10.1080/0886022X.2020.1841655. PMID: 33143476Free PMC Article
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article
Prognostic factors in ectopic Cushing's syndrome due to neuroendocrine tumors: a multicenter study.
Davi' MV, Cosaro E, Piacentini S, Reimondo G, Albiger N, Arnaldi G, Faggiano A, Mantovani G, Fazio N, Piovesan A, Arvat E, Grimaldi F, Canu L, Mannelli M, Ambrogio AG, Pecori Giraldi F, Martini C, Lania A, Albertelli M, Ferone D, Zatelli MC, Campana D, Colao A, Scaroni C, Terzolo M, De Marinis L, Cingarlini S, Micciolo R, Francia G
Eur J Endocrinol 2017 Apr;176(4):453-461. doi: 10.1530/EJE-16-0809. PMID: 28183788
Aberrant hormone activity by tumors of gynecologic importance.
Shane JM, Naftolin F
Am J Obstet Gynecol 1975 Jan 1;121(1):133-43. doi: 10.1016/0002-9378(75)90991-6. PMID: 163584

Clinical prediction guides

Prognostic factors in ectopic Cushing's syndrome due to neuroendocrine tumors: a multicenter study.
Davi' MV, Cosaro E, Piacentini S, Reimondo G, Albiger N, Arnaldi G, Faggiano A, Mantovani G, Fazio N, Piovesan A, Arvat E, Grimaldi F, Canu L, Mannelli M, Ambrogio AG, Pecori Giraldi F, Martini C, Lania A, Albertelli M, Ferone D, Zatelli MC, Campana D, Colao A, Scaroni C, Terzolo M, De Marinis L, Cingarlini S, Micciolo R, Francia G
Eur J Endocrinol 2017 Apr;176(4):453-461. doi: 10.1530/EJE-16-0809. PMID: 28183788
Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome?
Cozzolino M, Ureña-Torres P, Vervloet MG, Brandenburg V, Bover J, Goldsmith D, Larsson TE, Massy ZA, Mazzaferro S; CKD-MBD Working Group of ERA-EDTA
Nephrol Dial Transplant 2014 Oct;29(10):1815-20. Epub 2014 Feb 9 doi: 10.1093/ndt/gft514. PMID: 24516228
Fuller Albright and our current understanding of calcium and phosphorus regulation and primary hyperparathyroidism.
Felsenfeld AJ, Levine BS, Kleeman CR
Nefrologia 2011;31(3):346-57. doi: 10.3265/Nefrologia.pre2011.Mar.10774. PMID: 21629339
Paraneoplastic hypercalcemia in ovarian tumors.
Holtz G, Johnson TR Jr, Schrock ME
Obstet Gynecol 1979 Oct;54(4):483-7. PMID: 492633
Aberrant hormone activity by tumors of gynecologic importance.
Shane JM, Naftolin F
Am J Obstet Gynecol 1975 Jan 1;121(1):133-43. doi: 10.1016/0002-9378(75)90991-6. PMID: 163584

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