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Gastric Gastrointestinal Stromal Tumor

MedGen UID:
232231
•Concept ID:
C1333768
•
Neoplastic Process
Synonyms: Digestive Stromal Neoplasm of Stomach; Digestive Stromal Neoplasm of the Stomach; Digestive Stromal Tumor of Stomach; Digestive Stromal Tumor of the Stomach; Gastric Digestive Stromal Neoplasm; Gastric Digestive Stromal Tumor; Gastric GIST; Gastrointestinal Stromal Neoplasm of Stomach; Gastrointestinal Stromal Neoplasm of the Stomach; Gastrointestinal stromal tumor of stomach; Gastrointestinal Stromal Tumor of Stomach; Gastrointestinal Stromal Tumor of the Stomach; GIST of Stomach; GIST of the Stomach; Stomach Digestive Stromal Neoplasm; Stomach Digestive Stromal Tumor
SNOMED CT: Gastrointestinal stromal tumor of stomach (445736006)

Definition

A gastrointestinal stromal tumor that arises from the stomach. It covers a spectrum of benign to malignant soft tissue neoplasms and includes most gastric smooth muscle tumors, leiomyoblastomas, and tumors formerly called gastrointestinal autonomic nerve tumors. [from NCI]

Professional guidelines

PubMed

Kinase genotype analysis of gastric gastrointestinal stromal tumor cytology samples using targeted next-generation sequencing.
Gleeson FC, Kipp BR, Kerr SE, Voss JS, Graham RP, Campion MB, Minot DM, Tu ZJ, Klee EW, Lazaridis KN, Henry MR, Levy MJ
Clin Gastroenterol Hepatol 2015 Jan;13(1):202-6. Epub 2014 Jul 3 doi: 10.1016/j.cgh.2014.06.024. PMID: 24997326
Diagnosis and treatment of gastric gastrointestinal stromal tumor less than 5 cm in diameter.
Wang S, Ye YJ
Zhonghua Wei Chang Wai Ke Za Zhi 2010 Jul;13(7):477-80. PMID: 20722225

Recent clinical studies

Etiology

Robotic Function-Preserving Resection of Gastric Gastrointestinal Stromal Tumor.
Lwin TM, Fong ZV, Narayan RR, Wang SJ, Wang J
J Surg Res 2023 Oct;290:164-170. Epub 2023 Jun 1 doi: 10.1016/j.jss.2023.04.021. PMID: 37269799
Comparison of Modified Cap-Assisted Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in Treating Intraluminal Gastric Gastrointestinal Stromal Tumor (≤20 mm).
Meng R, Ni M, Ren W, Zhou T, Zhang X, Yan P, Ding X, Xu G, Lv Y, Zou X, Zhou L, Wang L
Clin Transl Gastroenterol 2023 Jun 1;14(6):e00589. doi: 10.14309/ctg.0000000000000589. PMID: 37019655Free PMC Article
The Association between the Growth Pattern and Malignancy in the Formation of Ulceration in Gastric Gastrointestinal Stromal Tumor.
Shibata T, Koyama K, Yamada H, Kawamura T, Yoshida D, Osaki H, Horiguchi N, Funasaka K, Miyahara R, Nagasaka M, Nakagawa Y, Hashimoto S, Tahara T, Nakamura M, Arisawa T, Hirooka Y
Intern Med 2023 Sep 1;62(17):2451-2455. Epub 2023 Jan 12 doi: 10.2169/internalmedicine.0983-22. PMID: 36631094Free PMC Article
Clinical outcomes of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor.
Hanayama H, Katagata M, Sato T, Nakano H, Matsumoto T, Tada T, Watanabe Y, Hayase S, Okayama H, Momma T, Kato T, Hashimoto M, Nakamura J, Hikichi T, Saze Z, Kono K
Fukushima J Med Sci 2022;68(3):169-174. doi: 10.5387/fms.2021-25. PMID: 36543179Free PMC Article
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor?
Shannon AB, Song Y, Fraker DL, Roses RE, DeMatteo RP, Miura JT, Karakousis GC
Surgery 2021 Feb;169(2):419-425. Epub 2020 Aug 27 doi: 10.1016/j.surg.2020.07.018. PMID: 32863011

Diagnosis

Gastric gastrointestinal stromal tumor abscess.
Velilla Vico D, Carbonell Morote S, Ruiz de la Cuesta Tapia E, Ramia Ángel JM
Rev Esp Enferm Dig 2023 Jan;115(1):35-36. doi: 10.17235/reed.2022.8580/2022. PMID: 35255697
Gastroduodenal intussusception caused by gastric gastrointestinal stromal tumor in adults: a case report and literature review.
Zhang W, Chen H, Zhu L, Kong Z, Wang T, Li W
J Int Med Res 2022 May;50(5):3000605221100772. doi: 10.1177/03000605221100772. PMID: 35632985Free PMC Article
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor?
Shannon AB, Song Y, Fraker DL, Roses RE, DeMatteo RP, Miura JT, Karakousis GC
Surgery 2021 Feb;169(2):419-425. Epub 2020 Aug 27 doi: 10.1016/j.surg.2020.07.018. PMID: 32863011
Differentiation of Gastric Schwannoma From Gastric Gastrointestinal Stromal Tumor With Dual-Phase Contrast-Enhanced Computed Tomography.
Li R, Gan H, Ni S, Fu Y, Zhu H, Peng W
J Comput Assist Tomogr 2019 Sep/Oct;43(5):741-746. doi: 10.1097/RCT.0000000000000902. PMID: 31356524
Necessity for resection of gastric gastrointestinal stromal tumors ≤ 20 mm.
Koga T, Hirayama Y, Yoshiya S, Taketani K, Nakanoko T, Yoshida R, Minagawa R, Kai M, Kajiyama K, Akahoshi K, Maehara Y
Anticancer Res 2015 Apr;35(4):2341-4. PMID: 25862898

Therapy

Robotic Function-Preserving Resection of Gastric Gastrointestinal Stromal Tumor.
Lwin TM, Fong ZV, Narayan RR, Wang SJ, Wang J
J Surg Res 2023 Oct;290:164-170. Epub 2023 Jun 1 doi: 10.1016/j.jss.2023.04.021. PMID: 37269799
Comparison of Modified Cap-Assisted Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in Treating Intraluminal Gastric Gastrointestinal Stromal Tumor (≤20 mm).
Meng R, Ni M, Ren W, Zhou T, Zhang X, Yan P, Ding X, Xu G, Lv Y, Zou X, Zhou L, Wang L
Clin Transl Gastroenterol 2023 Jun 1;14(6):e00589. doi: 10.14309/ctg.0000000000000589. PMID: 37019655Free PMC Article
Clinical outcomes of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor.
Hanayama H, Katagata M, Sato T, Nakano H, Matsumoto T, Tada T, Watanabe Y, Hayase S, Okayama H, Momma T, Kato T, Hashimoto M, Nakamura J, Hikichi T, Saze Z, Kono K
Fukushima J Med Sci 2022;68(3):169-174. doi: 10.5387/fms.2021-25. PMID: 36543179Free PMC Article
A Huge Malignant Gastric Gastrointestinal Stromal Tumor in a Young Patient.
Jeong YJ, Hwang HS, Park YE, Nam KH, Oh SJ
Korean J Gastroenterol 2022 Apr 25;79(4):177-181. doi: 10.4166/kjg.2022.006. PMID: 35473776
Differentiation of Gastric Schwannoma From Gastric Gastrointestinal Stromal Tumor With Dual-Phase Contrast-Enhanced Computed Tomography.
Li R, Gan H, Ni S, Fu Y, Zhu H, Peng W
J Comput Assist Tomogr 2019 Sep/Oct;43(5):741-746. doi: 10.1097/RCT.0000000000000902. PMID: 31356524

Prognosis

Efficacy analysis of endoscopic treatment of giant gastric gastrointestinal stromal tumors (≥5 cm).
Zhang J, Cao X, Dai N, Zhu S, Guo C
Eur J Surg Oncol 2023 Oct;49(10):106955. Epub 2023 Jun 11 doi: 10.1016/j.ejso.2023.06.007. PMID: 37330349
Predictors of the difficulty for endoscopic resection of gastric gastrointestinal stromal tumor and follow-up data.
Su W, Wang M, Zhang D, Zhu Y, Lv M, Zhu L, He J, Hu H, Zhou P
J Gastroenterol Hepatol 2022 Jan;37(1):48-55. Epub 2021 Aug 16 doi: 10.1111/jgh.15650. PMID: 34368989
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor?
Shannon AB, Song Y, Fraker DL, Roses RE, DeMatteo RP, Miura JT, Karakousis GC
Surgery 2021 Feb;169(2):419-425. Epub 2020 Aug 27 doi: 10.1016/j.surg.2020.07.018. PMID: 32863011
Endoscopic submucosal dissection for gastric gastrointestinal stromal tumors: a retrospective cohort study.
An W, Sun PB, Gao J, Jiang F, Liu F, Chen J, Wang D, Li ZS, Shi XG
Surg Endosc 2017 Nov;31(11):4522-4531. Epub 2017 Apr 3 doi: 10.1007/s00464-017-5511-3. PMID: 28374257
Laparoscopic resection for large gastric gastrointestinal stromal tumor (GIST): intermediate follow-up results.
Hsiao CY, Yang CY, Lai IR, Chen CN, Lin MT
Surg Endosc 2015 Apr;29(4):868-73. Epub 2014 Jul 23 doi: 10.1007/s00464-014-3742-0. PMID: 25052129

Clinical prediction guides

Comparison of Modified Cap-Assisted Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in Treating Intraluminal Gastric Gastrointestinal Stromal Tumor (≤20 mm).
Meng R, Ni M, Ren W, Zhou T, Zhang X, Yan P, Ding X, Xu G, Lv Y, Zou X, Zhou L, Wang L
Clin Transl Gastroenterol 2023 Jun 1;14(6):e00589. doi: 10.14309/ctg.0000000000000589. PMID: 37019655Free PMC Article
A Huge Malignant Gastric Gastrointestinal Stromal Tumor in a Young Patient.
Jeong YJ, Hwang HS, Park YE, Nam KH, Oh SJ
Korean J Gastroenterol 2022 Apr 25;79(4):177-181. doi: 10.4166/kjg.2022.006. PMID: 35473776
Predictors of the difficulty for endoscopic resection of gastric gastrointestinal stromal tumor and follow-up data.
Su W, Wang M, Zhang D, Zhu Y, Lv M, Zhu L, He J, Hu H, Zhou P
J Gastroenterol Hepatol 2022 Jan;37(1):48-55. Epub 2021 Aug 16 doi: 10.1111/jgh.15650. PMID: 34368989
Endoscopic submucosal dissection for gastric gastrointestinal stromal tumors: a retrospective cohort study.
An W, Sun PB, Gao J, Jiang F, Liu F, Chen J, Wang D, Li ZS, Shi XG
Surg Endosc 2017 Nov;31(11):4522-4531. Epub 2017 Apr 3 doi: 10.1007/s00464-017-5511-3. PMID: 28374257
Necessity for resection of gastric gastrointestinal stromal tumors ≤ 20 mm.
Koga T, Hirayama Y, Yoshiya S, Taketani K, Nakanoko T, Yoshida R, Minagawa R, Kai M, Kajiyama K, Akahoshi K, Maehara Y
Anticancer Res 2015 Apr;35(4):2341-4. PMID: 25862898

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