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Grade 1 Clear Cell Renal Cell Carcinoma

MedGen UID:
232245
Concept ID:
C1333829
Neoplastic Process
Synonym: Grade 1 Conventional (Clear Cell) Renal Cell Carcinoma

Definition

A clear cell renal cell carcinoma characterized by absent or inconspicuous and basophilic nucleoli at x 400 magnification. (WHO 1982 /ISUP 2014) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O
Mod Pathol 2021 Jun;34(6):1167-1184. Epub 2021 Feb 1 doi: 10.1038/s41379-021-00737-6. PMID: 33526874
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Recent clinical studies

Etiology

Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Chen S, Jiang L, Gao F, Zhang E, Wang T, Zhang N, Wang X, Zheng J
Br J Cancer 2022 Mar;126(5):771-777. Epub 2021 Nov 25 doi: 10.1038/s41416-021-01640-2. PMID: 34824449Free PMC Article
Yin X, Wang Z, Wang J, Xu Y, Kong W, Zhang J
Oncoimmunology 2021;10(1):1933332. Epub 2021 Jun 30 doi: 10.1080/2162402X.2021.1933332. PMID: 34262797Free PMC Article
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J
Lancet Oncol 2015 Nov;16(15):1473-1482. Epub 2015 Oct 22 doi: 10.1016/S1470-2045(15)00290-9. PMID: 26482279

Diagnosis

Pan X, Huang B, Ma Q, Ren J, Liu Y, Wang C, Zhang D, Fu J, Ran L, Yu T, Li H, Wang X, Yang F, Liang C, Zhang Y, Wang S, Ren J, Li W, Wang Y, Xiao B
Clin Transl Med 2022 Jul;12(7):e994. doi: 10.1002/ctm2.994. PMID: 35876041Free PMC Article
Vano YA, Elaidi R, Bennamoun M, Chevreau C, Borchiellini D, Pannier D, Maillet D, Gross-Goupil M, Tournigand C, Laguerre B, Barthélémy P, Coquan E, Gravis G, Houede N, Cancel M, Huillard O, Beuzeboc P, Fournier L, Méjean A, Cathelineau X, Doumerc N, Paparel P, Bernhard JC, de la Taille A, Bensalah K, Tricard T, Waeckel T, Pignot G, Braychenko E, Caruso S, Sun CM, Verkarre V, Lacroix G, Moreira M, Meylan M, Bougouïn A, Phan L, Thibault-Carpentier C, Zucman-Rossi J, Fridman WH, Sautès-Fridman C, Oudard S
Lancet Oncol 2022 May;23(5):612-624. Epub 2022 Apr 4 doi: 10.1016/S1470-2045(22)00128-0. PMID: 35390339
Wang Q, Xu J, Xiong Z, Xu T, Liu J, Liu Y, Chen J, Shi J, Shou Y, Yue C, Liu D, Liang H, Yang H, Yang X, Zhang X
J Transl Med 2021 Oct 9;19(1):417. doi: 10.1186/s12967-021-03087-8. PMID: 34627268Free PMC Article
Tong Y, Kai J, Wang S, Yu Y, Xie S, Zheng H, Wang Y, Liu Y, Zhu K, Guan X, Guo L, Lu R
Cell Death Dis 2021 Jun 16;12(7):621. doi: 10.1038/s41419-021-03901-7. PMID: 34135317Free PMC Article
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310

Therapy

Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators
Lancet Oncol 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. PMID: 36055304
Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Chang YH, Hajek J, Symeonides SN, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Gurney H, Chevreau C, Melichar B, Kopyltsov E, Alva A, Burke JM, Doshi G, Topart D, Oudard S, Hammers H, Kitamura H, Bedke J, Perini RF, Zhang P, Imai K, Willemann-Rogerio J, Quinn DI, Powles T; KEYNOTE-564 Investigators
N Engl J Med 2021 Aug 19;385(8):683-694. doi: 10.1056/NEJMoa2106391. PMID: 34407342
Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juárez VM, Hsieh JJ, Basso U, Shah AY, Suárez C, Hamzaj A, Goh JC, Barrios C, Richardet M, Porta C, Kowalyszyn R, Feregrino JP, Żołnierek J, Pook D, Kessler ER, Tomita Y, Mizuno R, Bedke J, Zhang J, Maurer MA, Simsek B, Ejzykowicz F, Schwab GM, Apolo AB, Motzer RJ; CheckMate 9ER Investigators
N Engl J Med 2021 Mar 4;384(9):829-841. doi: 10.1056/NEJMoa2026982. PMID: 33657295Free PMC Article
Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, Vynnychenko I, Kryzhanivska A, Bondarenko I, Azevedo SJ, Borchiellini D, Szczylik C, Markus M, McDermott RS, Bedke J, Tartas S, Chang YH, Tamada S, Shou Q, Perini RF, Chen M, Atkins MB, Powles T; KEYNOTE-426 Investigators
N Engl J Med 2019 Mar 21;380(12):1116-1127. Epub 2019 Feb 16 doi: 10.1056/NEJMoa1816714. PMID: 30779529
Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B; CheckMate 214 Investigators
N Engl J Med 2018 Apr 5;378(14):1277-1290. Epub 2018 Mar 21 doi: 10.1056/NEJMoa1712126. PMID: 29562145Free PMC Article

Prognosis

Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators
Lancet Oncol 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. PMID: 36055304
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Chen S, Jiang L, Gao F, Zhang E, Wang T, Zhang N, Wang X, Zheng J
Br J Cancer 2022 Mar;126(5):771-777. Epub 2021 Nov 25 doi: 10.1038/s41416-021-01640-2. PMID: 34824449Free PMC Article
Mou Y, Wu J, Zhang Y, Abdihamid O, Duan C, Li B
BMC Cancer 2021 Jan 5;21(1):18. doi: 10.1186/s12885-020-07726-z. PMID: 33402128Free PMC Article
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310

Clinical prediction guides

Li K, Li Y, Lyu Y, Tan L, Zheng X, Jiang H, Wen H, Feng C
Front Immunol 2022;13:853088. Epub 2022 May 16 doi: 10.3389/fimmu.2022.853088. PMID: 35651604Free PMC Article
Lee CH, Voss MH, Carlo MI, Chen YB, Zucker M, Knezevic A, Lefkowitz RA, Shapnik N, Dadoun C, Reznik E, Shah NJ, Owens CN, McHugh DJ, Aggen DH, Laccetti AL, Kotecha R, Feldman DR, Motzer RJ
J Clin Oncol 2022 Jul 20;40(21):2333-2341. Epub 2022 Mar 17 doi: 10.1200/JCO.21.01944. PMID: 35298296Free PMC Article
Chen S, Jiang L, Gao F, Zhang E, Wang T, Zhang N, Wang X, Zheng J
Br J Cancer 2022 Mar;126(5):771-777. Epub 2021 Nov 25 doi: 10.1038/s41416-021-01640-2. PMID: 34824449Free PMC Article
Liu M, Pan Q, Xiao R, Yu Y, Lu W, Wang L
Sci Rep 2020 Jul 31;10(1):12949. doi: 10.1038/s41598-020-67760-6. PMID: 32737333Free PMC Article
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310

Recent systematic reviews

Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Quhal F, Mori K, Bruchbacher A, Resch I, Mostafaei H, Pradere B, Schuettfort VM, Laukhtina E, Egawa S, Fajkovic H, Remzi M, Shariat SF, Schmidinger M
Eur Urol Oncol 2021 Oct;4(5):755-765. Epub 2021 Mar 20 doi: 10.1016/j.euo.2021.03.001. PMID: 33757737
Hussaini S, Chehade R, Boldt RG, Raphael J, Blanchette P, Maleki Vareki S, Fernandes R
Cancer Treat Rev 2021 Jan;92:102134. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102134. PMID: 33302134
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR
Ann Oncol 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. PMID: 28945858
Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R, Iyoha E, Bass EB, Allaf ME
J Urol 2016 Oct;196(4):989-99. Epub 2016 May 6 doi: 10.1016/j.juro.2016.04.081. PMID: 27157369Free PMC Article

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