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Grade 2 Invasive Breast Carcinoma

MedGen UID:
232247
•Concept ID:
C1333838
•
Neoplastic Process
Synonyms: Grade 2 Infiltrating Breast Carcinoma; Intermediate Combined Histologic Grade Infiltrating Breast Carcinoma; Moderately Differentiated Infiltrating Breast Carcinoma; Moderately Differentiated Invasive Breast Carcinoma; Moderately Favorable Infiltrating Breast Carcinoma

Definition

A moderately differentiated invasive breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Invasive Breast Carcinoma

Professional guidelines

PubMed

Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline.
Shaitelman SF, Anderson BM, Arthur DW, Bazan JG, Bellon JR, Bradfield L, Coles CE, Gerber NK, Kathpal M, Kim L, Laronga C, Meattini I, Nichols EM, Pierce LJ, Poppe MM, Spears PA, Vinayak S, Whelan T, Lyons JA
Pract Radiat Oncol 2024 Mar-Apr;14(2):112-132. Epub 2023 Nov 15 doi: 10.1016/j.prro.2023.11.001. PMID: 37977261
Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment.
Conte P, Ascierto PA, Patelli G, Danesi R, Vanzulli A, Sandomenico F, Tarsia P, Cattelan A, Comes A, De Laurentiis M, Falcone A, Regge D, Richeldi L, Siena S
ESMO Open 2022 Apr;7(2):100404. Epub 2022 Feb 24 doi: 10.1016/j.esmoop.2022.100404. PMID: 35219244Free PMC Article
Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article

Recent clinical studies

Etiology

Asprosin and meteorin-like protein immunoreactivity in invasive ductal breast carcinoma stages.
Akkus G, Koyuturk LC, Yilmaz M, Hancer S, Ozercan IH, Kuloglu T
Tissue Cell 2022 Aug;77:101855. Epub 2022 Jun 17 doi: 10.1016/j.tice.2022.101855. PMID: 35749857
CD8+ TILS Expression in Invasive Breast Carcinoma (No Special Type).
Astuti A, Miskad UA, Arsyadi G, Zainuddin AA, Wahid S, Nelwan BJ
Asian Pac J Cancer Prev 2022 May 1;23(5):1813-1816. doi: 10.31557/APJCP.2022.23.5.1813. PMID: 35633568Free PMC Article
Clinicopathologic Characteristics and Prognosis of Invasive Papillary Carcinoma of the Breast.
Huang K, Appiah L, Mishra A, Bagaria SP, Gabriel ME, Misra S
J Surg Res 2021 May;261:105-112. Epub 2021 Jan 7 doi: 10.1016/j.jss.2020.12.026. PMID: 33422900
Neuroendocrine breast carcinoma: a rare but challenging entity.
Trevisi E, La Salvia A, Daniele L, Brizzi MP, De Rosa G, Scagliotti GV, Di Maio M
Med Oncol 2020 Jul 25;37(8):70. doi: 10.1007/s12032-020-01396-4. PMID: 32712767Free PMC Article
Neuroendocrine Tumors of the Breast.
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994

Diagnosis

Nucleolus assessment in invasive breast carcinoma, an objective parameter for histological grading.
Öztürk SD, Öztürk Ç, Okcu O, Şen B, Bedir R
Turk J Med Sci 2022 Aug;52(4):975-983. Epub 2022 Aug 10 doi: 10.55730/1300-0144.5398. PMID: 36326384Free PMC Article
Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Clinicopathologic Characteristics and Prognosis of Invasive Papillary Carcinoma of the Breast.
Huang K, Appiah L, Mishra A, Bagaria SP, Gabriel ME, Misra S
J Surg Res 2021 May;261:105-112. Epub 2021 Jan 7 doi: 10.1016/j.jss.2020.12.026. PMID: 33422900
Neuroendocrine breast carcinoma: a rare but challenging entity.
Trevisi E, La Salvia A, Daniele L, Brizzi MP, De Rosa G, Scagliotti GV, Di Maio M
Med Oncol 2020 Jul 25;37(8):70. doi: 10.1007/s12032-020-01396-4. PMID: 32712767Free PMC Article
Medullary breast carcinoma.
Malyuchik SS, Kiyamova RG
Exp Oncol 2008 Jun;30(2):96-101. PMID: 18566570

Therapy

Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial.
Vicini FA, Cecchini RS, White JR, Arthur DW, Julian TB, Rabinovitch RA, Kuske RR, Ganz PA, Parda DS, Scheier MF, Winter KA, Paik S, Kuerer HM, Vallow LA, Pierce LJ, Mamounas EP, McCormick B, Costantino JP, Bear HD, Germain I, Gustafson G, Grossheim L, Petersen IA, Hudes RS, Curran WJ Jr, Bryant JL, Wolmark N
Lancet 2019 Dec 14;394(10215):2155-2164. Epub 2019 Dec 5 doi: 10.1016/S0140-6736(19)32514-0. PMID: 31813636Free PMC Article
Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial.
Coles CE, Griffin CL, Kirby AM, Titley J, Agrawal RK, Alhasso A, Bhattacharya IS, Brunt AM, Ciurlionis L, Chan C, Donovan EM, Emson MA, Harnett AN, Haviland JS, Hopwood P, Jefford ML, Kaggwa R, Sawyer EJ, Syndikus I, Tsang YM, Wheatley DA, Wilcox M, Yarnold JR, Bliss JM; IMPORT Trialists
Lancet 2017 Sep 9;390(10099):1048-1060. Epub 2017 Aug 2 doi: 10.1016/S0140-6736(17)31145-5. PMID: 28779963Free PMC Article
Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials.
Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM, Thomson CA, Caan BJ, Tinker LF, Urrutia RP, Knudtson J, Anderson GL
JAMA Oncol 2015 Aug;1(5):611-21. doi: 10.1001/jamaoncol.2015.1546. PMID: 26182172Free PMC Article
Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.
Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM; PRIME II investigators
Lancet Oncol 2015 Mar;16(3):266-73. Epub 2015 Jan 28 doi: 10.1016/S1470-2045(14)71221-5. PMID: 25637340

Prognosis

Subtypes of high-grade breast ductal carcinoma in situ (DCIS): incidence and potential clinical impact.
Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients.
Giaginis C, Sampani A, Kotta-Loizou I, Giannopoulou I, Danas E, Politi E, Tsourouflis G, Kouraklis G, Patsouris E, Keramopoulos A, Nakopoulou L, Theocharis S
Pathol Oncol Res 2018 Jul;24(3):631-640. Epub 2017 Aug 14 doi: 10.1007/s12253-017-0288-1. PMID: 28808873
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article

Clinical prediction guides

Nucleolus assessment in invasive breast carcinoma, an objective parameter for histological grading.
Öztürk SD, Öztürk Ç, Okcu O, Şen B, Bedir R
Turk J Med Sci 2022 Aug;52(4):975-983. Epub 2022 Aug 10 doi: 10.55730/1300-0144.5398. PMID: 36326384Free PMC Article
Association of Proliferative Activity in Invasive Ductal Carcinoma Breast in Pakistani Population.
Henna N, Rehman A, Niazi FB, Sami W, Aslam U
Asian Pac J Cancer Prev 2022 Mar 1;23(3):971-975. doi: 10.31557/APJCP.2022.23.3.971. PMID: 35345370Free PMC Article
Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418

Recent systematic reviews

Tumor budding in breast carcinoma: A systematic review and meta-analysis.
Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268
Breast cancer prognosis and P-cadherin expression: systematic review and study-level meta-analysis.
Qi R, Lin J, Chen S, Jiang J, Zhang X, Yao B, Zheng H, Jin Z, Yuan Y, Hou W, Hua B, Guo Q
BMJ Support Palliat Care 2022 Dec;12(e6):e893-e905. Epub 2020 Sep 17 doi: 10.1136/bmjspcare-2020-002204. PMID: 32943470
Partial breast irradiation versus whole breast radiotherapy for early breast cancer.
Hickey BE, Lehman M
Cochrane Database Syst Rev 2021 Aug 30;8(8):CD007077. doi: 10.1002/14651858.CD007077.pub4. PMID: 34459500Free PMC Article
Tumour-infiltrating lymphocytes in non-invasive breast cancer: A systematic review and meta-analysis.
Caparica R, Bruzzone M, Agostinetto E, Franzoi MA, Ceppi M, Radosevic-Robin N, Penault-Llorca F, Willard-Gallo K, Loi S, Salgado R, de Azambuja E
Breast 2021 Oct;59:183-192. Epub 2021 Jul 9 doi: 10.1016/j.breast.2021.07.007. PMID: 34273666Free PMC Article
Breast cancer in elderly women and altered clinico-pathological characteristics: a systematic review.
Lodi M, Scheer L, Reix N, Heitz D, Carin AJ, Thiébaut N, Neuberger K, Tomasetto C, Mathelin C
Breast Cancer Res Treat 2017 Dec;166(3):657-668. Epub 2017 Aug 12 doi: 10.1007/s10549-017-4448-5. PMID: 28803352

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