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Grade 3 Clear Cell Renal Cell Carcinoma

MedGen UID:
232248
Concept ID:
C1333841
Neoplastic Process
Synonym: Grade 3 Conventional (Clear Cell) Renal Cell Carcinoma

Definition

A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 100 magnification. (WHO 1982 /ISUP 2014) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Ou SL, Luo J, Wei H, Qin XL, Du SY, Wang S, Jiang Q
Front Immunol 2022;13:953761. Epub 2022 Jul 13 doi: 10.3389/fimmu.2022.953761. PMID: 35911744Free PMC Article
Nocera L, Karakiewicz PI, Wenzel M, Tian Z, Shariat SF, Saad F, Chun FKH, Briganti A, Kapoor A, Lalani AK
J Urol 2022 Jan;207(1):16-24. Epub 2021 Sep 21 doi: 10.1097/JU.0000000000002252. PMID: 34546767
Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O
Mod Pathol 2021 Jun;34(6):1167-1184. Epub 2021 Feb 1 doi: 10.1038/s41379-021-00737-6. PMID: 33526874

Recent clinical studies

Etiology

Chen YW, Rini BI
Curr Oncol Rep 2022 Jun;24(6):695-702. Epub 2022 Mar 5 doi: 10.1007/s11912-022-01196-1. PMID: 35247142
Yin X, Wang Z, Wang J, Xu Y, Kong W, Zhang J
Oncoimmunology 2021;10(1):1933332. Epub 2021 Jun 30 doi: 10.1080/2162402X.2021.1933332. PMID: 34262797Free PMC Article
Martínez Chanzá N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC
Lancet Oncol 2019 Apr;20(4):581-590. Epub 2019 Feb 28 doi: 10.1016/S1470-2045(18)30907-0. PMID: 30827746Free PMC Article
Ravaud A, Motzer RJ, Pandha HS, George DJ, Pantuck AJ, Patel A, Chang YH, Escudier B, Donskov F, Magheli A, Carteni G, Laguerre B, Tomczak P, Breza J, Gerletti P, Lechuga M, Lin X, Martini JF, Ramaswamy K, Casey M, Staehler M, Patard JJ; S-TRAC Investigators
N Engl J Med 2016 Dec 8;375(23):2246-2254. Epub 2016 Oct 9 doi: 10.1056/NEJMoa1611406. PMID: 27718781
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J
Lancet Oncol 2015 Nov;16(15):1473-1482. Epub 2015 Oct 22 doi: 10.1016/S1470-2045(15)00290-9. PMID: 26482279

Diagnosis

Pan X, Huang B, Ma Q, Ren J, Liu Y, Wang C, Zhang D, Fu J, Ran L, Yu T, Li H, Wang X, Yang F, Liang C, Zhang Y, Wang S, Ren J, Li W, Wang Y, Xiao B
Clin Transl Med 2022 Jul;12(7):e994. doi: 10.1002/ctm2.994. PMID: 35876041Free PMC Article
Vano YA, Elaidi R, Bennamoun M, Chevreau C, Borchiellini D, Pannier D, Maillet D, Gross-Goupil M, Tournigand C, Laguerre B, Barthélémy P, Coquan E, Gravis G, Houede N, Cancel M, Huillard O, Beuzeboc P, Fournier L, Méjean A, Cathelineau X, Doumerc N, Paparel P, Bernhard JC, de la Taille A, Bensalah K, Tricard T, Waeckel T, Pignot G, Braychenko E, Caruso S, Sun CM, Verkarre V, Lacroix G, Moreira M, Meylan M, Bougouïn A, Phan L, Thibault-Carpentier C, Zucman-Rossi J, Fridman WH, Sautès-Fridman C, Oudard S
Lancet Oncol 2022 May;23(5):612-624. Epub 2022 Apr 4 doi: 10.1016/S1470-2045(22)00128-0. PMID: 35390339
Gleeson JP, Nikolovski I, Dinatale R, Zucker M, Knezevic A, Patil S, Ged Y, Kotecha RR, Shapnik N, Murray S, Russo P, Coleman J, Lee CH, Stadler ZK, Hakimi AA, Feldman DR, Motzer RJ, Reznik E, Voss MH, Chen YB, Carlo MI
Clin Cancer Res 2021 May 15;27(10):2910-2919. Epub 2021 Mar 3 doi: 10.1158/1078-0432.CCR-20-4367. PMID: 33658299Free PMC Article
Deuker M, Stolzenbach F, Rosiello G, Palumbo C, Martin T, Tian Z, Chun FK, Saad F, Shariat SF, Kapoor A, Karakiewicz PI
J Urol 2020 Oct;204(4):671-676. Epub 2020 Apr 6 doi: 10.1097/JU.0000000000001063. PMID: 32250728
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310

Therapy

Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators
Lancet Oncol 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. PMID: 36055304
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Chang YH, Hajek J, Symeonides SN, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Gurney H, Chevreau C, Melichar B, Kopyltsov E, Alva A, Burke JM, Doshi G, Topart D, Oudard S, Hammers H, Kitamura H, Bedke J, Perini RF, Zhang P, Imai K, Willemann-Rogerio J, Quinn DI, Powles T; KEYNOTE-564 Investigators
N Engl J Med 2021 Aug 19;385(8):683-694. doi: 10.1056/NEJMoa2106391. PMID: 34407342
Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juárez VM, Hsieh JJ, Basso U, Shah AY, Suárez C, Hamzaj A, Goh JC, Barrios C, Richardet M, Porta C, Kowalyszyn R, Feregrino JP, Żołnierek J, Pook D, Kessler ER, Tomita Y, Mizuno R, Bedke J, Zhang J, Maurer MA, Simsek B, Ejzykowicz F, Schwab GM, Apolo AB, Motzer RJ; CheckMate 9ER Investigators
N Engl J Med 2021 Mar 4;384(9):829-841. doi: 10.1056/NEJMoa2026982. PMID: 33657295Free PMC Article
Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B; CheckMate 214 Investigators
N Engl J Med 2018 Apr 5;378(14):1277-1290. Epub 2018 Mar 21 doi: 10.1056/NEJMoa1712126. PMID: 29562145Free PMC Article

Prognosis

Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators
Lancet Oncol 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. PMID: 36055304
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Chen S, Jiang L, Gao F, Zhang E, Wang T, Zhang N, Wang X, Zheng J
Br J Cancer 2022 Mar;126(5):771-777. Epub 2021 Nov 25 doi: 10.1038/s41416-021-01640-2. PMID: 34824449Free PMC Article
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544

Clinical prediction guides

Lee CH, Voss MH, Carlo MI, Chen YB, Zucker M, Knezevic A, Lefkowitz RA, Shapnik N, Dadoun C, Reznik E, Shah NJ, Owens CN, McHugh DJ, Aggen DH, Laccetti AL, Kotecha R, Feldman DR, Motzer RJ
J Clin Oncol 2022 Jul 20;40(21):2333-2341. Epub 2022 Mar 17 doi: 10.1200/JCO.21.01944. PMID: 35298296Free PMC Article
Chen S, Jiang L, Gao F, Zhang E, Wang T, Zhang N, Wang X, Zheng J
Br J Cancer 2022 Mar;126(5):771-777. Epub 2021 Nov 25 doi: 10.1038/s41416-021-01640-2. PMID: 34824449Free PMC Article
Yin X, Wang Z, Wang J, Xu Y, Kong W, Zhang J
Oncoimmunology 2021;10(1):1933332. Epub 2021 Jun 30 doi: 10.1080/2162402X.2021.1933332. PMID: 34262797Free PMC Article
Martínez Chanzá N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC
Lancet Oncol 2019 Apr;20(4):581-590. Epub 2019 Feb 28 doi: 10.1016/S1470-2045(18)30907-0. PMID: 30827746Free PMC Article
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310

Recent systematic reviews

Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Quhal F, Mori K, Bruchbacher A, Resch I, Mostafaei H, Pradere B, Schuettfort VM, Laukhtina E, Egawa S, Fajkovic H, Remzi M, Shariat SF, Schmidinger M
Eur Urol Oncol 2021 Oct;4(5):755-765. Epub 2021 Mar 20 doi: 10.1016/j.euo.2021.03.001. PMID: 33757737
Hussaini S, Chehade R, Boldt RG, Raphael J, Blanchette P, Maleki Vareki S, Fernandes R
Cancer Treat Rev 2021 Jan;92:102134. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102134. PMID: 33302134
Hofmann F, Hwang EC, Lam TB, Bex A, Yuan Y, Marconi LS, Ljungberg B
Cochrane Database Syst Rev 2020 Oct 14;10(10):CD012796. doi: 10.1002/14651858.CD012796.pub2. PMID: 33058158Free PMC Article
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR
Ann Oncol 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. PMID: 28945858

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