U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 2 Colon Adenocarcinoma

MedGen UID:
232252
Concept ID:
C1333859
Neoplastic Process
Synonyms: Grade II Colon Adenocarcinoma; Moderately Differentiated Colon Adenocarcinoma

Definition

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Colon Adenocarcinoma

Professional guidelines

PubMed

Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A, Saunders BP, Thomas-Gibson S, Tolan DJM, Whyte S, Bonnington S, Scope A, Wong R, Hibbert B, Marsh J, Moores B, Cross A, Sharp L
Gut 2020 Feb;69(2):201-223. Epub 2019 Nov 27 doi: 10.1136/gutjnl-2019-319858. PMID: 31776230Free PMC Article
Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, Repici A, Vieth M, De Ceglie A, Amato A, Berr F, Bhandari P, Bialek A, Conio M, Haringsma J, Langner C, Meisner S, Messmann H, Morino M, Neuhaus H, Piessevaux H, Rugge M, Saunders BP, Robaszkiewicz M, Seewald S, Kashin S, Dumonceau JM, Hassan C, Deprez PH
Endoscopy 2015 Sep;47(9):829-54. Epub 2015 Aug 28 doi: 10.1055/s-0034-1392882. PMID: 26317585
Gonzalez QH, Heslin MJ, Dávila-Cervantes A, Alvarez-Tostado J, de los Monteros AE, Shore G, Vickers SM
Am Surg 2008 Mar;74(3):214-6. PMID: 18376684

Recent clinical studies

Etiology

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article
André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-Fisch I, de Gramont A; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
N Engl J Med 2004 Jun 3;350(23):2343-51. doi: 10.1056/NEJMoa032709. PMID: 15175436

Diagnosis

Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article

Therapy

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoué C, Aprile G, Antonuzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C; GONO Foundation Investigators
Lancet Oncol 2022 Jul;23(7):876-887. Epub 2022 May 27 doi: 10.1016/S1470-2045(22)00274-1. PMID: 35636444
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-Fisch I, de Gramont A; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
N Engl J Med 2004 Jun 3;350(23):2343-51. doi: 10.1056/NEJMoa032709. PMID: 15175436

Prognosis

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Wang Y, Zhang Y, Wang F, Li T, Song X, Shi H, Du J, Zhang H, Jing H, Han J, Tong D, Zhang J
Sci Rep 2022 Nov 2;12(1):18518. doi: 10.1038/s41598-022-21328-8. PMID: 36323715Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article

Clinical prediction guides

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article

Recent systematic reviews

Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A
Gastrointest Endosc 2021 Jan;93(1):77-85.e6. Epub 2020 Jun 26 doi: 10.1016/j.gie.2020.06.059. PMID: 32598963
Meester RGS, van Herk MMAGC, Lansdorp-Vogelaar I, Ladabaum U
Gastroenterology 2020 Jul;159(1):105-118.e25. Epub 2020 Mar 18 doi: 10.1053/j.gastro.2020.03.025. PMID: 32199884Free PMC Article
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...