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Head and Neck Disorder

MedGen UID:: 232269
•Concept ID:: C1333941
•: Disease or Syndrome

Definition

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the head and neck region. This category includes inflammatory disorders, benign neoplasms, precancerous conditions, and malignant neoplasms. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHead and Neck Disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Head and Neck Disorder
        Abnormal pituitary gland morphology
        Abnormal posterior pituitary morphogenesis
        Central diabetes insipidus
        Neoplasm of the posterior pituitary
        Posterior pituitary dysgenesis
        Abnormal size of pituitary gland
        Enlarged pituitary gland
        Small pituitary gland
        Abnormal thyroid-stimulating hormone level
        Decreased thyroid-stimulating hormone level
        Elevated circulating thyroid-stimulating hormone concentration
        Inappropriately normal thyroid-stimulating hormone level
        Abnormality of the anterior pituitary
        Anterior pituitary dysgenesis
        Ectopic anterior pituitary gland
        Hyperpituitarism
        Hypopituitarism
        Pituitary calcification
        Pituitary resistance to thyroid hormone
        Diabetes insipidus
        Adipsic Diabetes Insipidus
        Dipsogenic diabetes insipidus
        Nephrogenic diabetes insipidus
        Wolfram syndrome
        Empty sella syndrome
        Hypophysitis
        Primary hypophysitis
        Inappropriate antidiuretic hormone secretion
        Neoplasm of the pituitary gland
        Anterior Pituitary Gland Neoplasm
        Benign neoplasm of pituitary gland
        Neoplasm of the anterior pituitary
        Pituitary cancer
        Pituitary carcinoma
        Pituitary corticotropic cell adenoma
        Prolactin-producing pituitary gland adenoma
        Prolactinoma
        Sellar Paraganglioma
        Somatotroph Pituitary Neuroendocrine Tumor
        Non-Neoplastic Pituitary Gland Disorder
        Ectopic posterior pituitary
        Lymphocytic Neurohypophysitis
        Necrosis of pituitary
        Pituitary apoplexy
        Pituitary gland hypoplasia
        Pituitary gland infarction
        Disorder of neck
        Disorder of parathyroid gland
        Hyperparathyroidism
        Hypoparathyroidism
        Neoplasm of the parathyroid gland
        Non-Neoplastic Parathyroid Gland Disorder
        Disorder of pharynx
        Dysphagia
        Lemierre syndrome
        Nasopharyngeal disorder
        Neoplasm of the pharynx
        Non-Neoplastic Pharyngeal Disorder
        Pharyngitis
        Velopharyngeal insufficiency
        Disorder of thyroid gland
        Euthyroid sick syndrome
        Goiter
        Hyperthyroidism
        Hyperthyroxinemia
        Hypothyroidism
        Non-Neoplastic Thyroid Gland Disorder
        Thyroid C cell hyperplasia
        Thyroid dysgenesis
        Thyroid nodule
        Thyroid tumor
        Thyroiditis
        Laryngeal disorder
        Congenital laryngomalacia
        Disorder of voice
        Laryngeal edema
        Laryngeal granuloma
        Laryngeal Precancerous Condition
        Laryngeal stenosis
        Laryngeal tuberculosis
        Laryngitis
        Laryngocele
        Laryngopharyngeal reflux
        Neoplasm of the larynx
        Non-Neoplastic Laryngeal Disorder
        Supraglottitis
        Vocal cord dysfunction
        Vocal cord paralysis
        Neoplasm of neck
        Benign neoplasm of neck
        Ectopic Cervical Thymoma
        Jugular Foramen Neoplasm
        Malignant tumor of neck
        Parapharyngeal Neoplasm
        Retropharyngeal Neoplasm
        Non-Neoplastic Neck Disorder
        Disorder of salivary gland
        Calculus, Salivary
        Sialodocholithiasis
        Sialolithiasis
        Excessive salivation
        Drooling
        Fistula of salivary gland
        IgG4-related dacryoadenitis and sialadenitis
        Kimura disease
        Necrotizing sialometaplasia
        Non-Neoplastic Salivary Gland Disorder
        Benign lymphoepithelial lesion of salivary gland
        Lymphoepithelial Sialadenitis
        Parotitis
        Salivary Duct Inflammation
        Salivary Gland Infection
        Sialadenitis
        Parotid disorder
        Parotid gland neoplasm
        Salivary gland neoplasm
        Benign neoplasm of salivary gland
        Hybrid Salivary Gland Tumor
        Malignant Salivary Gland Neoplasm
        Neoplasm of major salivary gland
        Neoplasm of minor salivary gland
        Pleomorphic adenoma
        Salivary Gland Myoepithelial Tumor
        Salivary gland oncocytoma
        Salivary Gland Sialoblastoma
        Sublingual gland neoplasm
        Submandibular gland neoplasm
        Submandibular gland disorder
        Xerostomia
        Radiation-induced xerostomia
        Sjogren syndrome
        Head and neck neoplasm
        Benign Head and Neck Neoplasm
        Benign carotid body paraganglioma
        Benign neoplasm of ear
        Benign neoplasm of oral cavity
        Benign Orbit Neoplasm
        Benign Sinonasal Neoplasm
        Benign Skull Neoplasm
        Head and Neck Nevus
        Facial neoplasm
        Eyelid neoplasm
        Head and neck cancer
        Head and neck carcinoma
        Head and Neck Follicular Dendritic Cell Sarcoma
        Head and Neck Sarcoma
        Malignant carotid body paraganglioma
        Malignant ear neoplasm
        Malignant jugulotympanic paraganglioma
        Malignant Orbit Neoplasm
        Malignant Sinonasal Neoplasm
        Malignant Skull Neoplasm
        Malignant tumor of oral cavity
        Metastatic Malignant Head and Neck Neoplasm
        Metastatic Malignant Neoplasm in the Head and Neck
        Mucosal Melanoma of the Head and Neck
        Recurrent Malignant Head and Neck Neoplasm
        Refractory Malignant Head and Neck Neoplasm
        Head and Neck Histiocytic and Dendritic Cell Neoplasm
        Head and Neck Langerhans Cell Histiocytosis
        Thyroid Gland Histiocytic and Dendritic Cell Neoplasm
        Head and Neck Melanocytic Neoplasm
        Juvenile nasopharyngeal angiofibroma
        Nasal cavity and paranasal sinus neoplasm
        Nasal cavity neoplasm
        Paranasal sinus neoplasm
        Primary Sinonasal Meningioma
        Sinonasal Ameloblastoma
        Sinonasal Soft Tissue Neoplasm
        Neoplasm of esophagus
        Barrett esophagus
        Benign neoplasm of esophagus
        Esophageal carcinoma
        Esophageal dysplasia
        Esophageal granular cell tumor
        Esophageal Neuroendocrine Neoplasm
        Esophageal Soft Tissue Neoplasm
        Esophageal squamous cell carcinoma
        Esophageal squamous papilloma
        Malignant tumor of esophagus
        Neoplasm of the ear
        External ear neoplasm
        Neoplasm of the inner ear
        Neoplasm of the middle ear
        Neoplasm of the outer ear
        Neoplasm of the oral cavity
        Buccal mucosa neoplasm
        Epignathus
        Gingival neoplasm
        Neoplasm of floor of mouth
        Neoplasm of the lip
        Neoplasm of the tongue
        Odontogenic neoplasm
        Oral Cavity Granular Cell Tumor
        Oral Cavity Soft Tissue Neoplasm
        Oral Intraepithelial Neoplasia
        Oral Mucosa Langerhans Cell Histiocytosis
        Oral mucosa leukoplakia
        Ossifying fibroma of the jaw
        Palate neoplasm
        Tonsillar Neoplasm
        Neoplasm of the trachea
        Benign neoplasm of trachea
        Tracheal cancer
        Tracheal papilloma
        Orbit neoplasm
        Intraorbital meningioma
        Orbit Paraganglioma
        Otorhinolaryngologic Neoplasms
        Neoplasm of the nose
        Vestibular schwannoma
        Paraganglioma of head and neck
        Chemodectoma
        Glomus jugular tumor
        Laryngeal Paraganglioma
        Nasopharyngeal Paraganglioma
        Thyroid Gland Paraganglioma
        Vagal paraganglioma
        Skull neoplasm
        Jaw neoplasm
        Maxillofacial Neoplasm
        Skull base neoplasm
        Squamous cell carcinoma of the head and neck
        ASPH-Positive Head and Neck Squamous Cell Carcinoma
        Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Head and Neck Basaloid Carcinoma
        Head and Neck Keratinizing Squamous Cell Carcinoma
        Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma
        Laryngeal squamous cell carcinoma
        Lip and oral cavity squamous cell carcinoma
        Metastatic Head and Neck Squamous Cell Carcinoma
        Nasal cavity and paranasal sinus squamous cell carcinoma
        Pharyngeal squamous cell carcinoma
        Recurrent Head and Neck Squamous Cell Carcinoma
        Refractory Head and Neck Squamous Cell Carcinoma
        Resectable Head and Neck Squamous Cell Carcinoma
        Salivary gland squamous cell carcinoma
        Unresectable Head and Neck Squamous Cell Carcinoma
        Head and Neck Precancerous Condition
        Oral Cavity and Lip Precancerous Condition
        Erythroplakia
        Oral Cavity Submucous Fibrosis
        Smokers keratosis
        Non-Neoplastic Head and Neck Disorder
        Cholesteatoma
        Cholesteatoma of middle ear
        Maxillary sinus cholesteatoma
        Lymphedema of the Head and Neck
        Non-Neoplastic Ear Disorder
        Ear infection
        Hearing problem
        Non-Neoplastic External Ear Disorder
        Non-Neoplastic Inner Ear Disorder
        Non-Neoplastic Middle Ear Disorder
        Non-Neoplastic Oral Disorder
        Non-Neoplastic Lip Disorder
        Non-Neoplastic Oral Cavity Disorder
        Non-Neoplastic Sinonasal Disorder
        Non-Neoplastic Nasal Cavity Disorder
        Non-Neoplastic Paranasal Sinus Disorder
        Sinonasal Respiratory Epithelial Adenomatoid Hamartoma
        Sinonasal Seromucinous Hamartoma
        Otolaryngologic Disorder
        Disorder of ear
        Congenital Microtia
        Disorder of inner ear
        Ear pain
        External ear disorder
        Geniculate herpes zoster
        Labyrinthine disorder
        Middle ear disorder
        Myringosclerosis
        Otitis
        Otomycosis
        Otosclerosis
        Ototoxicity
        Retrocochlear disease
        Susac syndrome
        Mouth disorder
        Abnormality of the mouth
        Alveolar periostitis
        Behcet disease
        Burning mouth syndrome
        Cancrum oris
        Disorder of teeth AND/OR supporting structures
        Disorder of tonsil (palatine tonsil)
        Edentulous
        Facial nerve disorder
        Facial palsy
        Facial paralysis
        Focal epithelial hyperplasia
        Gingival disorder
        Hemifacial atrophy
        Hemifacial spasm
        Lip disorder
        Ludwig angina
        Melkersson-Rosenthal syndrome
        Mucous inflammation
        Oral bleeding
        Oral candidiasis
        Oral fistula
        Oral leukoedema
        Oral lichen planus
        Oral Manifestations
        Oral submucous fibrosis
        Oral tuberculosis
        Oral ulcer
        Orofacial granulomatosis
        Periodontal disorder
        Ranula
        Stomatitis
        Tongue disorder
        Sinonasal Disorder
        Disorder of nasal sinus
        Nasal cavity disorder
        Skull disorder

Professional guidelines

PubMed

Rhinitis 2020: A practice parameter update.

Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s):, Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters:, Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors:, Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC
J Allergy Clin Immunol 2020 Oct;146(4):721-767. Epub 2020 Jul 22 doi: 10.1016/j.jaci.2020.07.007. PMID: 32707227

Clinical Practice Guideline: Ménière's Disease.

Basura GJ, Adams ME, Monfared A, Schwartz SR, Antonelli PJ, Burkard R, Bush ML, Bykowski J, Colandrea M, Derebery J, Kelly EA, Kerber KA, Koopman CF, Kuch AA, Marcolini E, McKinnon BJ, Ruckenstein MJ, Valenzuela CV, Vosooney A, Walsh SA, Nnacheta LC, Dhepyasuwan N, Buchanan EM
Otolaryngol Head Neck Surg 2020 Apr;162(2_suppl):S1-S55. doi: 10.1177/0194599820909438. PMID: 32267799

Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update).

Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Steiner RW, Do BT, Voelker CC, Waguespack RW, Corrigan MD
Otolaryngol Head Neck Surg 2017 Mar;156(3_suppl):S1-S47. doi: 10.1177/0194599816689667. PMID: 28248609

See all (4705)

Recent clinical studies

Etiology

Interventions for head and neck cancer survivors: Systematic review.

Margalit DN, Salz T, Venchiarutti R, Milley K, McNamara M, Chima S, Wong J, Druce P, Nekhlyudov L
Head Neck 2022 Nov;44(11):2579-2599. Epub 2022 Jul 18 doi: 10.1002/hed.27142. PMID: 35848095 Free PMC Article

American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment.

Shonka DC Jr, Ho A, Chintakuntlawar AV, Geiger JL, Park JC, Seetharamu N, Jasim S, Abdelhamid Ahmed AH, Bible KC, Brose MS, Cabanillas ME, Dabekaussen K, Davies L, Dias-Santagata D, Fagin JA, Faquin WC, Ghossein RA, Gopal RK, Miyauchi A, Nikiforov YE, Ringel MD, Robinson B, Ryder MM, Sherman EJ, Sadow PM, Shin JJ, Stack BC Jr, Tuttle RM, Wirth LJ, Zafereo ME Jr, Randolph GW
Head Neck 2022 Jun;44(6):1277-1300. Epub 2022 Mar 11 doi: 10.1002/hed.27025. PMID: 35274388 Free PMC Article

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy.

Baudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, Rottey S, De Neve W, Sundahl N, Van Nuffelen G, Duprez F
Head Neck 2019 Oct;41(10):3594-3603. Epub 2019 Jul 22 doi: 10.1002/hed.25880. PMID: 31329343

Update on primary head and neck mucosal melanoma.

López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, Shaha AR, Hunt JL, de Bree R, Takes RP, Rinaldo A, Ferlito A
Head Neck 2016 Jan;38(1):147-55. Epub 2015 May 22 doi: 10.1002/hed.23872. PMID: 25242350 Free PMC Article

Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).

Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

See all (29152)

Diagnosis

Ethical framework for head and neck cancer care impacted by COVID-19.

Shuman AG, Campbell BH; AHNS Ethics & Professionalism Service
Head Neck 2020 Jun;42(6):1214-1217. Epub 2020 Apr 28 doi: 10.1002/hed.26193. PMID: 32329948 Free PMC Article

Oligometastatic head and neck cancer: Comprehensive review.

Vengaloor Thomas T, Packianathan S, Bhanat E, Albert A, Abraham A, Gordy X, Kanakamedala M, Mehta D, Vijayakumar S
Head Neck 2020 Aug;42(8):2194-2201. Epub 2020 Mar 27 doi: 10.1002/hed.26144. PMID: 32220043

Comprehensive management of HPV-related squamous cell carcinoma of the head and neck of unknown primary.

Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162

Distant metastases in head and neck cancer.

Duprez F, Berwouts D, De Neve W, Bonte K, Boterberg T, Deron P, Huvenne W, Rottey S, Mareel M
Head Neck 2017 Sep;39(9):1733-1743. Epub 2017 Jun 26 doi: 10.1002/hed.24687. PMID: 28650113

Update on primary head and neck mucosal melanoma.

See all (22675)

Therapy

Interventions for head and neck cancer survivors: Systematic review.

Head and neck cancer and non-steroidal anti-inflammatory drugs: Systematic review and meta-analysis.

Saka-Herrán C, Jané-Salas E, Estrugo-Devesa A, López-López J
Head Neck 2021 May;43(5):1664-1682. Epub 2021 Mar 8 doi: 10.1002/hed.26663. PMID: 33682986

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy.

Efficacy of electrical stimulation and exercise for dysphagia in patients with head and neck cancer: A randomized clinical trial.

Langmore SE, McCulloch TM, Krisciunas GP, Lazarus CL, Van Daele DJ, Pauloski BR, Rybin D, Doros G
Head Neck 2016 Apr;38 Suppl 1(Suppl 1):E1221-31. Epub 2015 Oct 15 doi: 10.1002/hed.24197. PMID: 26469360 Free PMC Article

Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).

Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

See all (14977)

Prognosis

Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers.

Liu W, Qdaisat A, Zhou S, Fuller CD, Ferrarotto R, Guo M, Lai SY, Cardoso R, Mohamed ASR, Lopez G, Narayanan S, van Dijk LV, Cohen L, Bruera E, Yeung SJ, Hanna EY
Head Neck 2021 Feb;43(2):613-621. Epub 2020 Oct 23 doi: 10.1002/hed.26510. PMID: 33094893 Free PMC Article

Special considerations for elderly patients with head and neck cancer during the COVID-19 pandemic.

Sharma A, Crosby DL
Head Neck 2020 Jun;42(6):1147-1149. Epub 2020 Apr 28 doi: 10.1002/hed.26216. PMID: 32343444 Free PMC Article

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy.

Radiotherapy for benign head and neck paragangliomas.

Mendenhall WM, Morris CG, Amdur RJ, Hitchcock KE, Silver NL, Dziegielewski PT
Head Neck 2019 Jul;41(7):2107-2110. Epub 2019 Feb 19 doi: 10.1002/hed.25664. PMID: 30779406

Distant metastases in head and neck cancer.

Duprez F, Berwouts D, De Neve W, Bonte K, Boterberg T, Deron P, Huvenne W, Rottey S, Mareel M
Head Neck 2017 Sep;39(9):1733-1743. Epub 2017 Jun 26 doi: 10.1002/hed.24687. PMID: 28650113

See all (20424)

Clinical prediction guides

Head and neck cancer and non-steroidal anti-inflammatory drugs: Systematic review and meta-analysis.

Saka-Herrán C, Jané-Salas E, Estrugo-Devesa A, López-López J
Head Neck 2021 May;43(5):1664-1682. Epub 2021 Mar 8 doi: 10.1002/hed.26663. PMID: 33682986

Individualized prediction of late-onset dysphagia in head and neck cancer survivors.

Aylward A, Park J, Abdelaziz S, Hunt JP, Buchmann LO, Cannon RB, Rowe K, Snyder J, Deshmukh V, Newman M, Wan Y, Fraser A, Smith K, Lloyd S, Hitchcock Y, Hashibe M, Monroe MM
Head Neck 2020 Apr;42(4):708-718. Epub 2020 Feb 7 doi: 10.1002/hed.26039. PMID: 32031294

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy.

Efficacy of electrical stimulation and exercise for dysphagia in patients with head and neck cancer: A randomized clinical trial.

Head and neck fascia and compartments: no space for spaces.

Guidera AK, Dawes PJ, Fong A, Stringer MD
Head Neck 2014 Jul;36(7):1058-68. Epub 2014 Jan 29 doi: 10.1002/hed.23442. PMID: 23913739

See all (17139)

Recent systematic reviews

Interventions for head and neck cancer survivors: Systematic review.

Associations between sleep bruxism and other sleep-related disorders in adults: a systematic review.

Kuang B, Li D, Lobbezoo F, de Vries R, Hilgevoord A, de Vries N, Huynh N, Lavigne G, Aarab G
Sleep Med 2022 Jan;89:31-47. Epub 2021 Nov 19 doi: 10.1016/j.sleep.2021.11.008. PMID: 34879286

Swallowing exercises for head and neck cancer patients: A systematic review and meta-analysis of randomized control trials.

Banda KJ, Chu H, Kao CC, Voss J, Chiu HL, Chang PC, Chen R, Chou KR
Int J Nurs Stud 2021 Feb;114:103827. Epub 2020 Nov 11 doi: 10.1016/j.ijnurstu.2020.103827. PMID: 33352439

Headache and pregnancy: a systematic review.

Negro A, Delaruelle Z, Ivanova TA, Khan S, Ornello R, Raffaelli B, Terrin A, Reuter U, Mitsikostas DD; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2017 Oct 19;18(1):106. doi: 10.1186/s10194-017-0816-0. PMID: 29052046 Free PMC Article

American Cancer Society Head and Neck Cancer Survivorship Care Guideline.

Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

See all (1369)

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Head and Neck Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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