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Liver solitary fibrous tumor

MedGen UID:
232273
•Concept ID:
C1333965
•
Neoplastic Process
Synonyms: Fibroma of Liver; fibroma of liver; Fibroma of the Liver; fibroma of the liver; Hepatic Fibroma; hepatic fibroma; Liver Fibroma; liver fibroma; liver localised fibrous mesothelioma; liver localised fibrous tumour; Liver Localized Fibrous Mesothelioma; liver localized fibrous mesothelioma; Liver Localized Fibrous Tumor; liver localized fibrous tumor; Liver Solitary Fibrous Tumor; liver solitary fibrous tumor
 
Monarch Initiative: MONDO:0004705

Definition

A solitary fibrous tumor that arises from the liver. It affects females more frequently than males. Signs and symptoms include the presence of an abdominal mass and abdominal discomfort. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver solitary fibrous tumor

Professional guidelines

PubMed

Rare benign liver tumors that require differentiation from hepatocellular carcinoma: focus on diagnosis and treatment.
Luo L, Wang T, Cheng M, Ge X, Song S, Zhu G, Xiao Y, Deng W, Xie J, Shan R
J Cancer Res Clin Oncol 2023 Jul;149(7):2843-2854. Epub 2022 Jul 5 doi: 10.1007/s00432-022-04169-w. PMID: 35789428
Multidisciplinary Treatment of Liver Metastases from Intracranial SFTs/HPCs: A Report of Three Consecutive Cases.
Krendl FJ, Messner F, Laimer G, Djanani A, Seeber A, Oberhuber G, Öfner D, Wolf D, Schneeberger S, Bale R, Margreiter C
Curr Oncol 2022 Nov 15;29(11):8720-8741. doi: 10.3390/curroncol29110687. PMID: 36421340Free PMC Article
Management of primary liver sarcomas.
Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, La Quaglia MP, Fong Y, Brennan MF, Blumgart LH, Dematteo RP
Cancer 2007 Apr 1;109(7):1391-6. doi: 10.1002/cncr.22530. PMID: 17315167

Recent clinical studies

Etiology

Clinicopathologic characterization and assessment of prognostic factors for intraabdominal solitary fibrous tumors involving the gastrointestinal tract and liver.
Liu X, Beltejar MJ, Liao X
Virchows Arch 2022 Nov;481(5):703-712. Epub 2022 Aug 17 doi: 10.1007/s00428-022-03396-3. PMID: 35978144
Clinicopathological analysis of retroperitoneal solitary fibrous tumours: a study of 31 cases.
Yuan X, Liu Y, Wang X, Chen Y, Zhang L, Wei J
Histol Histopathol 2022 Jan;37(1):43-50. Epub 2021 Nov 8 doi: 10.14670/HH-18-392. PMID: 34755327
Efficacy and Safety of Pazopanib for Recurrent or Metastatic Solitary Fibrous Tumor.
Ebata T, Shimoi T, Bun S, Miyake M, Yoshida A, Shimomura A, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Narita Y, Tamura K
Oncology 2018;94(6):340-344. Epub 2018 Apr 3 doi: 10.1159/000486623. PMID: 29614488
Solitary fibrous tumor of the liver: report of two cases and review of the literature.
Debs T, Kassir R, Amor IB, Martini F, Iannelli A, Gugenheim J
Int J Surg 2014 Dec;12(12):1291-4. Epub 2014 Nov 4 doi: 10.1016/j.ijsu.2014.10.037. PMID: 25448647
Solitary fibrous liver tumor: is surgical approach the best option?
Novais P, Robles-Medranda C, Pannain VL, Barbosa D, Biccas B, Fogaça H
J Gastrointestin Liver Dis 2010 Mar;19(1):81-4. PMID: 20361081

Diagnosis

A giant solitary fibrous tumour of the liver: a case report.
Roman J, Vávra P, Vávrová M, Židlík V, Pelikán A
Acta Chir Belg 2023 Feb;123(1):90-93. Epub 2021 Jun 2 doi: 10.1080/00015458.2021.1932180. PMID: 34006182
Efficacy and Safety of Pazopanib for Recurrent or Metastatic Solitary Fibrous Tumor.
Ebata T, Shimoi T, Bun S, Miyake M, Yoshida A, Shimomura A, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Narita Y, Tamura K
Oncology 2018;94(6):340-344. Epub 2018 Apr 3 doi: 10.1159/000486623. PMID: 29614488
Imaging features of rare mesenychmal liver tumours: beyond haemangiomas.
Thampy R, Elsayes KM, Menias CO, Pickhardt PJ, Kang HC, Deshmukh SP, Ahmed K, Korivi BR
Br J Radiol 2017 Nov;90(1079):20170373. Epub 2017 Aug 2 doi: 10.1259/bjr.20170373. PMID: 28766950Free PMC Article
Solitary Fibrous Tumor of the Liver: a Review of the Current Knowledge and Report of a New Case.
Beltrán MA
J Gastrointest Cancer 2015 Dec;46(4):333-42. doi: 10.1007/s12029-015-9769-1. PMID: 26490964
Solitary fibrous tumor of the liver: report of two cases and review of the literature.
Debs T, Kassir R, Amor IB, Martini F, Iannelli A, Gugenheim J
Int J Surg 2014 Dec;12(12):1291-4. Epub 2014 Nov 4 doi: 10.1016/j.ijsu.2014.10.037. PMID: 25448647

Therapy

Efficacy and Safety of Pazopanib for Recurrent or Metastatic Solitary Fibrous Tumor.
Ebata T, Shimoi T, Bun S, Miyake M, Yoshida A, Shimomura A, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Narita Y, Tamura K
Oncology 2018;94(6):340-344. Epub 2018 Apr 3 doi: 10.1159/000486623. PMID: 29614488
An update on primary hepatic solitary fibrous tumor: An examination of the clinical and pathological features of four case studies and a literature review.
Feng LH, Dong H, Zhu YY, Cong WM
Pathol Res Pract 2015 Dec;211(12):911-7. Epub 2015 Sep 10 doi: 10.1016/j.prp.2015.09.004. PMID: 26601735
Solitary fibrous liver tumor: is surgical approach the best option?
Novais P, Robles-Medranda C, Pannain VL, Barbosa D, Biccas B, Fogaça H
J Gastrointestin Liver Dis 2010 Mar;19(1):81-4. PMID: 20361081
Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia.
Guglielmi A, Frameglia M, Iuzzolino P, Martignoni G, De Manzoni G, Laterza E, Veraldi GF, Girlanda R
J Hepatobiliary Pancreat Surg 1998;5(2):212-6. doi: 10.1007/s005340050036. PMID: 9745091
Hepatic tumors induced by sex steroids.
Mays ET, Christopherson W
Semin Liver Dis 1984 May;4(2):147-57. doi: 10.1055/s-2008-1040654. PMID: 6087460

Prognosis

Clinicopathologic characterization and assessment of prognostic factors for intraabdominal solitary fibrous tumors involving the gastrointestinal tract and liver.
Liu X, Beltejar MJ, Liao X
Virchows Arch 2022 Nov;481(5):703-712. Epub 2022 Aug 17 doi: 10.1007/s00428-022-03396-3. PMID: 35978144
Clinicopathological analysis of retroperitoneal solitary fibrous tumours: a study of 31 cases.
Yuan X, Liu Y, Wang X, Chen Y, Zhang L, Wei J
Histol Histopathol 2022 Jan;37(1):43-50. Epub 2021 Nov 8 doi: 10.14670/HH-18-392. PMID: 34755327
Efficacy and Safety of Pazopanib for Recurrent or Metastatic Solitary Fibrous Tumor.
Ebata T, Shimoi T, Bun S, Miyake M, Yoshida A, Shimomura A, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Narita Y, Tamura K
Oncology 2018;94(6):340-344. Epub 2018 Apr 3 doi: 10.1159/000486623. PMID: 29614488
Solitary fibrous tumour of the liver-report on metastasis and local recurrence of a malignant case and review of literature.
Chen N, Slater K
World J Surg Oncol 2017 Jan 18;15(1):27. doi: 10.1186/s12957-017-1102-y. PMID: 28100235Free PMC Article
Solitary Fibrous Tumor of the Liver: a Review of the Current Knowledge and Report of a New Case.
Beltrán MA
J Gastrointest Cancer 2015 Dec;46(4):333-42. doi: 10.1007/s12029-015-9769-1. PMID: 26490964

Clinical prediction guides

Clinicopathologic characterization and assessment of prognostic factors for intraabdominal solitary fibrous tumors involving the gastrointestinal tract and liver.
Liu X, Beltejar MJ, Liao X
Virchows Arch 2022 Nov;481(5):703-712. Epub 2022 Aug 17 doi: 10.1007/s00428-022-03396-3. PMID: 35978144
Efficacy and Safety of Pazopanib for Recurrent or Metastatic Solitary Fibrous Tumor.
Ebata T, Shimoi T, Bun S, Miyake M, Yoshida A, Shimomura A, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Narita Y, Tamura K
Oncology 2018;94(6):340-344. Epub 2018 Apr 3 doi: 10.1159/000486623. PMID: 29614488
Clinical outcomes of intracranial solitary fibrous tumor and hemangiopericytoma: analysis according to the 2016 WHO classification of central nervous system tumors.
Kim BS, Kim Y, Kong DS, Nam DH, Lee JI, Suh YL, Seol HJ
J Neurosurg 2018 Dec 1;129(6):1384-1396. doi: 10.3171/2017.7.JNS171226. PMID: 29372881
Primary solitary fibrous tumors of liver: a case report and literature review.
Liu Q, Liu J, Chen W, Mao S, Guo Y
Diagn Pathol 2013 Dec 2;8:195. doi: 10.1186/1746-1596-8-195. PMID: 24294990Free PMC Article
Malignant solitary tumor in a child: a case report and review of the literature.
Wang H, Shen D, Hou Y
J Pediatr Surg 2011 Mar;46(3):e5-9. doi: 10.1016/j.jpedsurg.2010.11.025. PMID: 21376187

Recent systematic reviews

Surveillance for metastatic hemangiopericytoma-solitary fibrous tumors-systematic literature review on incidence, predictors and diagnosis of extra-cranial disease.
Ratneswaren T, Hogg FRA, Gallagher MJ, Ashkan K
J Neurooncol 2018 Jul;138(3):447-467. Epub 2018 Mar 17 doi: 10.1007/s11060-018-2836-2. PMID: 29551003
Primary hepatic malignant fibrous histiocytoma: clinicopathologic characteristics and prognostic value of ezrin expression.
Li YR, Akbari E, Tretiakova MS, Hart J, Akbari M, Urbanski SJ, Gao ZH
Am J Surg Pathol 2008 Aug;32(8):1144-58. doi: 10.1097/PAS.0b013e3181659791. PMID: 18545143

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