U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

High grade glandular intraepithelial neoplasia

MedGen UID:
232289
•Concept ID:
C1334014
•
Neoplastic Process
Synonyms: Glandular intraepithelial neoplasia grade III; Grade III Glandular Intraepithelial Neoplasia; High grade flat intraepithelial neoplasia; High Grade Glandular Intraepithelial Neoplasia
SNOMED CT: High grade flat intraepithelial neoplasia (818948002); High grade glandular intraepithelial neoplasia (818948002); Glandular intraepithelial neoplasia grade III (818948002)

Definition

This lesion shows moderate or marked architectural distortion with glandular crowding and prominent cellular atypia. It includes moderate dysplasia and severe dysplasia. (WHO, 2000) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh grade glandular intraepithelial neoplasia

Professional guidelines

PubMed

European consensus statement on expert colposcopy.
McGee AE, Alibegashvili T, Elfgren K, Frey B, Grigore M, Heinonen A, Jach R, Jariene K, Kesic V, Küppers V, Kyrgiou M, Leeson S, Louwers J, Mazurec M, Mergui J, Pedro A, Šavrova A, Siegler E, Tabuica U, Trojnarska D, Trzeszcz M, Turyna R, Volodko N, Cruickshank ME; European Federation for Colposcopy and Pathology of the Lower Genital Tract (EFC) and the European Society of Gynaecological Oncology (ESGO)
Eur J Obstet Gynecol Reprod Biol 2023 Nov;290:27-37. Epub 2023 Aug 31 doi: 10.1016/j.ejogrb.2023.08.369. PMID: 37716200
Management of cervical cytologic abnormalities.
Apgar BS, Brotzman G
Am Fam Physician 2004 Nov 15;70(10):1905-16. PMID: 15571057
Cervical squamous and glandular intraepithelial neoplasia: identification and current management approaches.
Wright VC
Salud Publica Mex 2003;45 Suppl 3:S417-29. doi: 10.1590/s0036-36342003000900016. PMID: 14746035

Recent clinical studies

Etiology

Endocervical carcinoma and precursor lesions: c-myc expression and the demonstration of field changes.
Polacarz SV, Darne J, Sheridan EG, Ginsberg R, Sharp F
J Clin Pathol 1991 Nov;44(11):896-9. doi: 10.1136/jcp.44.11.896. PMID: 1752978Free PMC Article
A case of glandular intraepithelial neoplasia involving the cervix and vagina.
Cullimore JE, Luesley DM, Rollason TP, Waddell C, Williams DR
Gynecol Oncol 1989 Aug;34(2):249-52. doi: 10.1016/0090-8258(89)90153-4. PMID: 2753431

Diagnosis

Evaluation of endoscopic and histopathological features of serrated adenoma of the colon.
Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S
Endoscopy 2001 Sep;33(9):761-5. doi: 10.1055/s-2001-16525. PMID: 11558029
A case of glandular intraepithelial neoplasia involving the cervix and vagina.
Cullimore JE, Luesley DM, Rollason TP, Waddell C, Williams DR
Gynecol Oncol 1989 Aug;34(2):249-52. doi: 10.1016/0090-8258(89)90153-4. PMID: 2753431

Prognosis

A case of glandular intraepithelial neoplasia involving the cervix and vagina.
Cullimore JE, Luesley DM, Rollason TP, Waddell C, Williams DR
Gynecol Oncol 1989 Aug;34(2):249-52. doi: 10.1016/0090-8258(89)90153-4. PMID: 2753431

Clinical prediction guides

Evaluation of endoscopic and histopathological features of serrated adenoma of the colon.
Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S
Endoscopy 2001 Sep;33(9):761-5. doi: 10.1055/s-2001-16525. PMID: 11558029

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...