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High grade glandular intraepithelial neoplasia

MedGen UID:
232289
Concept ID:
C1334014
Neoplastic Process
Synonyms: Glandular intraepithelial neoplasia grade III; Grade III Glandular Intraepithelial Neoplasia; High grade flat intraepithelial neoplasia; High Grade Glandular Intraepithelial Neoplasia
SNOMED CT: High grade flat intraepithelial neoplasia (818948002); High grade glandular intraepithelial neoplasia (818948002); Glandular intraepithelial neoplasia grade III (818948002)

Definition

This lesion shows moderate or marked architectural distortion with glandular crowding and prominent cellular atypia. It includes moderate dysplasia and severe dysplasia. (WHO, 2000) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh grade glandular intraepithelial neoplasia

Professional guidelines

PubMed

McGee AE, Alibegashvili T, Elfgren K, Frey B, Grigore M, Heinonen A, Jach R, Jariene K, Kesic V, Küppers V, Kyrgiou M, Leeson S, Louwers J, Mazurec M, Mergui J, Pedro A, Šavrova A, Siegler E, Tabuica U, Trojnarska D, Trzeszcz M, Turyna R, Volodko N, Cruickshank ME; European Federation for Colposcopy and Pathology of the Lower Genital Tract (EFC) and the European Society of Gynaecological Oncology (ESGO)
Eur J Obstet Gynecol Reprod Biol 2023 Nov;290:27-37. Epub 2023 Aug 31 doi: 10.1016/j.ejogrb.2023.08.369. PMID: 37716200
Zhang YJ, Dai Q, Sun DF, Xiong H, Tian XQ, Gao FH, Xu MH, Chen GQ, Han ZG, Fang JY
Ann Surg Oncol 2009 Sep;16(9):2617-28. Epub 2009 Jun 11 doi: 10.1245/s10434-009-0555-9. PMID: 19517193
Wright VC
Salud Publica Mex 2003;45 Suppl 3:S417-29. doi: 10.1590/s0036-36342003000900016. PMID: 14746035

Recent clinical studies

Etiology

Polacarz SV, Darne J, Sheridan EG, Ginsberg R, Sharp F
J Clin Pathol 1991 Nov;44(11):896-9. doi: 10.1136/jcp.44.11.896. PMID: 1752978Free PMC Article
Cullimore JE, Luesley DM, Rollason TP, Waddell C, Williams DR
Gynecol Oncol 1989 Aug;34(2):249-52. doi: 10.1016/0090-8258(89)90153-4. PMID: 2753431

Diagnosis

Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S
Endoscopy 2001 Sep;33(9):761-5. doi: 10.1055/s-2001-16525. PMID: 11558029
Cullimore JE, Luesley DM, Rollason TP, Waddell C, Williams DR
Gynecol Oncol 1989 Aug;34(2):249-52. doi: 10.1016/0090-8258(89)90153-4. PMID: 2753431

Prognosis

Cullimore JE, Luesley DM, Rollason TP, Waddell C, Williams DR
Gynecol Oncol 1989 Aug;34(2):249-52. doi: 10.1016/0090-8258(89)90153-4. PMID: 2753431

Clinical prediction guides

Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S
Endoscopy 2001 Sep;33(9):761-5. doi: 10.1055/s-2001-16525. PMID: 11558029

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