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Histiocytic and dendritic cell neoplasm

MedGen UID:
232291
•Concept ID:
C1334030
•
Neoplastic Process
Synonyms: histiocytic and dendritic cell; histiocytic and dendritic cell cancer; Histiocytic and Dendritic Cell Neoplasm; histiocytic and dendritic cell neoplasm; Histiocytic and Dendritic Cell Neoplasms; histiocytic and Dendritic cell neoplasms; histiocytic and dendritic cell tumor; Histiocytic and dendritic cell tumor; Histiocytic and Dendritic Cell Tumors; histiocytic and Dendritic cell tumors; histiocytic and dendritic cell tumour; histiocytic and Dendritic cell tumours
 
Monarch Initiative: MONDO:0006247
Orphanet: ORPHA98287

Definition

Rare tumors that affect the hematopoietic and lymphoid tissues. The cells of origin are the histiocytes and accessory cells. They can occur at any age and show no significant variations in geographical distribution. This category includes the histiocytic sarcoma, Langerhans cell histiocytosis, Langerhans cell sarcoma, interdigitading dendritic cell sarcoma/tumor, follicular dendritic cell sarcoma/tumor, and dendritic cell sarcoma, not otherwise specified. (WHO, 2001) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHistiocytic and dendritic cell neoplasm

Professional guidelines

PubMed

Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis.
Skala SL, Lucas DR, Dewar R
Arch Pathol Lab Med 2018 Nov;142(11):1322-1329. doi: 10.5858/arpa.2018-0220-RA. PMID: 30407858
Langerhans cell histiocytosis in adults: Advances in pathophysiology and treatment.
Kobayashi M, Tojo A
Cancer Sci 2018 Dec;109(12):3707-3713. Epub 2018 Oct 30 doi: 10.1111/cas.13817. PMID: 30281871Free PMC Article
Dendritic cell and histiocytic neoplasms: biology, diagnosis, and treatment.
Dalia S, Shao H, Sagatys E, Cualing H, Sokol L
Cancer Control 2014 Oct;21(4):290-300. doi: 10.1177/107327481402100405. PMID: 25310210

Recent clinical studies

Etiology

Histiocytic and dendritic cell neoplasms: Reappraisal of a Japanese series based on t(14;18) and neoplastic PD-L1 expression.
Okada K, Takahara T, Suzuki Y, Kohno K, Sakakibara A, Satou A, Takahashi E, Nakamura S
Pathol Int 2021 Jan;71(1):24-32. Epub 2020 Nov 25 doi: 10.1111/pin.13044. PMID: 33238073
Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion - case report and a review of the literature.
Mosiewicz A, Rola R, Jarosz B, Trojanowska A, Trojanowski T
Neurol Neurochir Pol 2010 Mar-Apr;44(2):196-203. doi: 10.1016/s0028-3843(14)60011-6. PMID: 20496290

Diagnosis

Histiocytic and dendritic cell neoplasms: Reappraisal of a Japanese series based on t(14;18) and neoplastic PD-L1 expression.
Okada K, Takahara T, Suzuki Y, Kohno K, Sakakibara A, Satou A, Takahashi E, Nakamura S
Pathol Int 2021 Jan;71(1):24-32. Epub 2020 Nov 25 doi: 10.1111/pin.13044. PMID: 33238073
Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node.
Shimono J, Miyoshi H, Arakawa F, Abe H, Miyagishima T, Akiba J, Teshima T, Ohshima K
Pathol Int 2018 Nov;68(11):614-617. Epub 2018 Sep 25 doi: 10.1111/pin.12722. PMID: 30255584
Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion - case report and a review of the literature.
Mosiewicz A, Rola R, Jarosz B, Trojanowska A, Trojanowski T
Neurol Neurochir Pol 2010 Mar-Apr;44(2):196-203. doi: 10.1016/s0028-3843(14)60011-6. PMID: 20496290

Prognosis

Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion - case report and a review of the literature.
Mosiewicz A, Rola R, Jarosz B, Trojanowska A, Trojanowski T
Neurol Neurochir Pol 2010 Mar-Apr;44(2):196-203. doi: 10.1016/s0028-3843(14)60011-6. PMID: 20496290

Clinical prediction guides

Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node.
Shimono J, Miyoshi H, Arakawa F, Abe H, Miyagishima T, Akiba J, Teshima T, Ohshima K
Pathol Int 2018 Nov;68(11):614-617. Epub 2018 Sep 25 doi: 10.1111/pin.12722. PMID: 30255584

Supplemental Content

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