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Central nervous system melanocytic neoplasm

MedGen UID:
232333
•Concept ID:
C1332887
•
Neoplastic Process
Synonyms: Central Nervous System Melanocytic Neoplasm; central nervous system melanocytic neoplasm; Central Nervous System Melanocytic Neoplasms; central nervous system melanocytic neoplasms; Central Nervous System Melanocytic Tumor; central nervous system melanocytic tumor; central nervous system melanocytic tumour; central nervous system primary melanocytic lesion; CNS Melanocytic Neoplasm; CNS melanocytic neoplasm; CNS Melanocytic Tumor; CNS melanocytic tumor; CNS melanocytic tumour; Melanocytic Neoplasm of Central Nervous System; melanocytic neoplasm of central nervous system; Melanocytic Neoplasm of CNS; melanocytic neoplasm of CNS; Melanocytic Neoplasm of the Central Nervous System; melanocytic neoplasm of the central nervous system; Melanocytic Neoplasm of the CNS; melanocytic neoplasm of the CNS; Melanocytic Tumor of Central Nervous System; melanocytic tumor of central nervous system; Melanocytic Tumor of CNS; melanocytic tumor of CNS; Melanocytic Tumor of the Central Nervous System; melanocytic tumor of the central nervous system; Melanocytic Tumor of the CNS; melanocytic tumor of the CNS; melanocytic tumour of central nervous system; melanocytic tumour of CNS; melanocytic tumour of the central nervous system; melanocytic tumour of the CNS; primary melanocytic lesion of meninges; primary melanocytic lesions of the CNS
 
Monarch Initiative: MONDO:0003222

Definition

A primary tumor of the central nervous system that arises from leptomeningeal melanocytes. It may present as a diffuse proliferative leptomeningeal process (often as a component of the neurocutaneous melanosis complex) or as a distinct mass lesion. [from NCI]

Professional guidelines

PubMed

Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Clinical characteristics and treatment outcomes of pigmented tumors in central nervous system: Focusing on melanocytic tumors.
Lyu L, Zou L, Jiang Y, Ding H, Chen C, Ye F, Hu Y, Yin S, Zhou P, Jiang S
J Clin Neurosci 2020 Nov;81:83-89. Epub 2020 Sep 29 doi: 10.1016/j.jocn.2020.09.009. PMID: 33222976
Primary sellar melanocytoma: pathological, clinical and treatment review.
Albano L, Losa M, Barzaghi LR, Spatola G, Panni P, Terreni MR, Mortini P
J Endocrinol Invest 2020 May;43(5):575-585. Epub 2019 Dec 3 doi: 10.1007/s40618-019-01158-8. PMID: 31797309

Recent clinical studies

Etiology

Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Giant congenital melanocytic nevus.
Viana AC, Gontijo B, Bittencourt FV
An Bras Dermatol 2013 Nov-Dec;88(6):863-78. doi: 10.1590/abd1806-4841.20132233. PMID: 24474093Free PMC Article

Diagnosis

Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Primary sellar melanocytoma.
Claus M, Van Der Linden M, Van Dorpe J, Lapauw B, T'Sjoen G
Pituitary 2021 Dec;24(6):970-977. Epub 2021 Sep 13 doi: 10.1007/s11102-021-01186-9. PMID: 34518998
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074

Therapy

MC1R Functions, Expression, and Implications for Targeted Therapy.
Guida S, Guida G, Goding CR
J Invest Dermatol 2022 Feb;142(2):293-302.e1. Epub 2021 Aug 4 doi: 10.1016/j.jid.2021.06.018. PMID: 34362555
Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.
Mandel VD, Persechino F, Berardi A, Ponti G, Ciardo S, Rossi C, Pellacani G, Farnetani F
Ital J Pediatr 2016 May 14;42(1):47. doi: 10.1186/s13052-016-0260-9. PMID: 27180150Free PMC Article
Dermal melanocytosis and associated disorders.
Franceschini D, Dinulos JG
Curr Opin Pediatr 2015 Aug;27(4):480-5. doi: 10.1097/MOP.0000000000000247. PMID: 26087431
From existing therapies to novel targets: a current view on melanoma.
Namkoong J, Martino JJ, Chen S
Front Biosci 2006 Sep 1;11:2081-92. doi: 10.2741/1951. PMID: 16720295

Prognosis

Meningioma and Other Meningeal Tumors.
Bailo M, Gagliardi F, Boari N, Spina A, Piloni M, Castellano A, Mortini P
Adv Exp Med Biol 2023;1405:73-97. doi: 10.1007/978-3-031-23705-8_3. PMID: 37452935
Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626
Primary melanocytic neoplasms of the central nervous system.
Liubinas SV, Maartens N, Drummond KJ
J Clin Neurosci 2010 Oct;17(10):1227-32. Epub 2010 Jun 16 doi: 10.1016/j.jocn.2010.01.017. PMID: 20558070

Clinical prediction guides

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.
Mormina E, Granata F, Vinci SL, Coglitore A, Caragliano AA, Tessitore A, Longo M, Visalli C
Curr Med Imaging 2021;17(12):1391-1402. doi: 10.2174/1573405617666210527091109. PMID: 34047260
Clinical characteristics and treatment outcomes of pigmented tumors in central nervous system: Focusing on melanocytic tumors.
Lyu L, Zou L, Jiang Y, Ding H, Chen C, Ye F, Hu Y, Yin S, Zhou P, Jiang S
J Clin Neurosci 2020 Nov;81:83-89. Epub 2020 Sep 29 doi: 10.1016/j.jocn.2020.09.009. PMID: 33222976
Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.
Mandel VD, Persechino F, Berardi A, Ponti G, Ciardo S, Rossi C, Pellacani G, Farnetani F
Ital J Pediatr 2016 May 14;42(1):47. doi: 10.1186/s13052-016-0260-9. PMID: 27180150Free PMC Article

Recent systematic reviews

Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis.
Fledderus AC, Widdershoven AL, Lapid O, Breugem CC, Pasmans SGMA, van der Horst CMAM, Engelen MM, Spuls PI
Orphanet J Rare Dis 2022 Mar 2;17(1):95. doi: 10.1186/s13023-022-02234-8. PMID: 35236387Free PMC Article
Epilepsy in isolated parenchymal neurocutaneous melanosis: A systematic review.
Pellino G, Gencarelli J, Bertelli S, Russo A, Fiumana E, Faggioli R
Epilepsy Behav 2020 Jun;107:107061. Epub 2020 Apr 6 doi: 10.1016/j.yebeh.2020.107061. PMID: 32272368

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