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Central nervous system melanocytic neoplasm

MedGen UID:
232333
Concept ID:
C1332887
Neoplastic Process
Synonyms: Central Nervous System Melanocytic Neoplasm; central nervous system melanocytic neoplasm; Central Nervous System Melanocytic Neoplasms; central nervous system melanocytic neoplasms; Central Nervous System Melanocytic Tumor; central nervous system melanocytic tumor; central nervous system melanocytic tumour; central nervous system primary melanocytic lesion; CNS Melanocytic Neoplasm; CNS melanocytic neoplasm; CNS Melanocytic Tumor; CNS melanocytic tumor; CNS melanocytic tumour; Melanocytic Neoplasm of Central Nervous System; melanocytic neoplasm of central nervous system; Melanocytic Neoplasm of CNS; melanocytic neoplasm of CNS; Melanocytic Neoplasm of the Central Nervous System; melanocytic neoplasm of the central nervous system; Melanocytic Neoplasm of the CNS; melanocytic neoplasm of the CNS; Melanocytic Tumor of Central Nervous System; melanocytic tumor of central nervous system; Melanocytic Tumor of CNS; melanocytic tumor of CNS; Melanocytic Tumor of the Central Nervous System; melanocytic tumor of the central nervous system; Melanocytic Tumor of the CNS; melanocytic tumor of the CNS; melanocytic tumour of central nervous system; melanocytic tumour of CNS; melanocytic tumour of the central nervous system; melanocytic tumour of the CNS; primary melanocytic lesion of meninges; primary melanocytic lesions of the CNS
 
Monarch Initiative: MONDO:0003222

Definition

A primary tumor of the central nervous system that arises from leptomeningeal melanocytes. It may present as a diffuse proliferative leptomeningeal process (often as a component of the neurocutaneous melanosis complex) or as a distinct mass lesion. [from NCI]

Professional guidelines

PubMed

Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Habibi Z, Ebrahimi H, Meybodi KT, Yaghmaei B, Nejat F
World Neurosurg 2021 Feb;146:e1063-e1070. Epub 2020 Nov 24 doi: 10.1016/j.wneu.2020.11.091. PMID: 33246180
Albano L, Losa M, Barzaghi LR, Spatola G, Panni P, Terreni MR, Mortini P
J Endocrinol Invest 2020 May;43(5):575-585. Epub 2019 Dec 3 doi: 10.1007/s40618-019-01158-8. PMID: 31797309

Recent clinical studies

Etiology

Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Kinsler VA, O'Hare P, Bulstrode N, Calonje JE, Chong WK, Hargrave D, Jacques T, Lomas D, Sebire NJ, Slater O
Br J Dermatol 2017 May;176(5):1131-1143. Epub 2017 Apr 4 doi: 10.1111/bjd.15301. PMID: 28078671Free PMC Article

Diagnosis

Kurokawa R, Kurokawa M, Isshiki S, Harada T, Nakaya M, Baba A, Naganawa S, Kim J, Bapuraj J, Srinivasan A, Abe O, Moritani T
Radiographics 2023 Aug;43(9):e230039. doi: 10.1148/rg.230039. PMID: 37535461
Bailo M, Gagliardi F, Boari N, Spina A, Piloni M, Castellano A, Mortini P
Adv Exp Med Biol 2023;1405:73-97. doi: 10.1007/978-3-031-23705-8_3. PMID: 37452935
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Viana AC, Gontijo B, Bittencourt FV
An Bras Dermatol 2013 Nov-Dec;88(6):863-78. doi: 10.1590/abd1806-4841.20132233. PMID: 24474093Free PMC Article

Therapy

Guida S, Guida G, Goding CR
J Invest Dermatol 2022 Feb;142(2):293-302.e1. Epub 2021 Aug 4 doi: 10.1016/j.jid.2021.06.018. PMID: 34362555
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Franceschini D, Dinulos JG
Curr Opin Pediatr 2015 Aug;27(4):480-5. doi: 10.1097/MOP.0000000000000247. PMID: 26087431
Tadini G, Restano L, Happle R, Itin P
Dermatology 2012;224(1):24-30. Epub 2012 Mar 9 doi: 10.1159/000336794. PMID: 22414678
de Wied D
Acta Neurobiol Exp (Wars) 1990;50(4-5):353-66. PMID: 1966658

Prognosis

Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Bailo M, Gagliardi F, Boari N, Spina A, Piloni M, Castellano A, Mortini P
Adv Exp Med Biol 2023;1405:73-97. doi: 10.1007/978-3-031-23705-8_3. PMID: 37452935
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Magaña M, Sánchez-Romero E, Magaña P, Beck-Magaña A, Magaña-Lozano M
Am J Dermatopathol 2015 Jan;37(1):31-7. doi: 10.1097/DAD.0000000000000183. PMID: 25140664

Clinical prediction guides

Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Dean DN, Lee JC
Mov Disord 2021 Jul;36(7):1489-1498. Epub 2021 May 22 doi: 10.1002/mds.28655. PMID: 34021920Free PMC Article
Herman H, Fazakas C, Haskó J, Molnár K, Mészáros Á, Nyúl-Tóth Á, Szabó G, Erdélyi F, Ardelean A, Hermenean A, Krizbai IA, Wilhelm I
J Cell Mol Med 2019 Apr;23(4):2619-2631. Epub 2019 Feb 2 doi: 10.1111/jcmm.14156. PMID: 30712288Free PMC Article
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Namkoong J, Martino JJ, Chen S
Front Biosci 2006 Sep 1;11:2081-92. doi: 10.2741/1951. PMID: 16720295

Recent systematic reviews

Fledderus AC, Widdershoven AL, Lapid O, Breugem CC, Pasmans SGMA, van der Horst CMAM, Engelen MM, Spuls PI
Orphanet J Rare Dis 2022 Mar 2;17(1):95. doi: 10.1186/s13023-022-02234-8. PMID: 35236387Free PMC Article
Pellino G, Gencarelli J, Bertelli S, Russo A, Fiumana E, Faggioli R
Epilepsy Behav 2020 Jun;107:107061. Epub 2020 Apr 6 doi: 10.1016/j.yebeh.2020.107061. PMID: 32272368

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