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Myeloproliferative neoplasm, unclassifiable

MedGen UID:
232365
Concept ID:
C1333046
Neoplastic Process
Synonyms: Chronic Myeloproliferative Disease, Unclassifiable; chronic myeloproliferative disease, unclassifiable; Chronic myeloproliferative disease, unclassifiable; Chronic Myeloproliferative Disorder, Unclassifiable; chronic myeloproliferative disorder, unclassifiable; CMPD, U; CMPD-U; MPN, U; MPN-U; Myeloproliferative neoplasm unclassifiable; Myeloproliferative Neoplasm, Unclassifiable; myeloproliferative neoplasm, unclassifiable; Unclassifiable Chronic Myeloproliferative Disease; unclassifiable chronic myeloproliferative disease; Unclassifiable Chronic Myeloproliferative Disorder; unclassifiable chronic myeloproliferative disorder; Undifferentiated myeloproliferative disease; undifferentiated myeloproliferative disease
SNOMED CT: Myeloproliferative neoplasm unclassifiable (1255668009)
 
Monarch Initiative: MONDO:0019452
Orphanet: ORPHA86830

Definition

Chronic myeloproliferative disease, unclassifiable is a hematological neoplasm characterized by clonal proliferation of myeloid precursors in the bone marrow, blood and other tissues (spleen, liver), with clinical, morphological and molecular features of myeloproliferative neoplasms (MPN), failing to meet criteria of a specific MPN. The presentation is nonspecific and variable and often includes leukocytosis, thrombocytosis and anemia. Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Myeloproliferative neoplasm, unclassifiable

Professional guidelines

PubMed

Hargreaves R, Harrison CN, McLornan DP
Curr Res Transl Med 2022 Jul;70(3):103338. Epub 2022 Feb 23 doi: 10.1016/j.retram.2022.103338. PMID: 35217310
Yun J, Kim JA, Park J, Im K, Lee YE, Jeong D, Ryu S, Lim KM, Kim SM, Ahn YO, Lee DS
Leuk Lymphoma 2020 Dec;61(14):3498-3502. Epub 2020 Sep 2 doi: 10.1080/10428194.2020.1808212. PMID: 32876501
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Recent clinical studies

Etiology

Li N, Chen M, Yin CC
Semin Diagn Pathol 2023 May;40(3):187-194. Epub 2023 Apr 13 doi: 10.1053/j.semdp.2023.04.007. PMID: 37087305
Hargreaves R, Harrison CN, McLornan DP
Curr Res Transl Med 2022 Jul;70(3):103338. Epub 2022 Feb 23 doi: 10.1016/j.retram.2022.103338. PMID: 35217310
McLornan DP, Hargreaves R, Hernández-Boluda JC, Harrison CN
Br J Haematol 2022 May;197(4):407-416. Epub 2022 Feb 22 doi: 10.1111/bjh.18087. PMID: 35191542
Deschamps P, Moonim M, Radia D, Curto-Garcia N, Woodley C, Bassiony S, O'Sullivan J, Harrington P, Raj K, Francis Y, Kordasti S, Ali S, Harrison CN, McLornan DP
Br J Haematol 2021 May;193(4):792-797. Epub 2021 Mar 9 doi: 10.1111/bjh.17375. PMID: 33751548
Gianelli U, Cattaneo D, Bossi A, Cortinovis I, Boiocchi L, Liu YC, Augello C, Bonometti A, Fiori S, Orofino N, Guidotti F, Orazi A, Iurlo A
Mod Pathol 2017 Feb;30(2):169-179. Epub 2016 Oct 14 doi: 10.1038/modpathol.2016.182. PMID: 27739437

Diagnosis

Li N, Chen M, Yin CC
Semin Diagn Pathol 2023 May;40(3):187-194. Epub 2023 Apr 13 doi: 10.1053/j.semdp.2023.04.007. PMID: 37087305
McLornan DP, Hargreaves R, Hernández-Boluda JC, Harrison CN
Br J Haematol 2022 May;197(4):407-416. Epub 2022 Feb 22 doi: 10.1111/bjh.18087. PMID: 35191542
Shallis RM, Zeidan AM
Best Pract Res Clin Haematol 2020 Jun;33(2):101132. Epub 2019 Dec 6 doi: 10.1016/j.beha.2019.101132. PMID: 32460977
Gianelli U, Cattaneo D, Bossi A, Cortinovis I, Boiocchi L, Liu YC, Augello C, Bonometti A, Fiori S, Orofino N, Guidotti F, Orazi A, Iurlo A
Mod Pathol 2017 Feb;30(2):169-179. Epub 2016 Oct 14 doi: 10.1038/modpathol.2016.182. PMID: 27739437
Klco JM, Vij R, Kreisel FH, Hassan A, Frater JL
Am J Clin Pathol 2010 Apr;133(4):602-15. doi: 10.1309/AJCPPPZ1WFVGNE4A. PMID: 20231614

Therapy

Shi S, Han J, Yao Y, Xu Y, Wu D, Wang Y
Transfusion 2020 Jul;60(7):1639-1642. Epub 2020 Mar 5 doi: 10.1111/trf.15735. PMID: 32134497
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Prognosis

Hargreaves R, Harrison CN, McLornan DP
Curr Res Transl Med 2022 Jul;70(3):103338. Epub 2022 Feb 23 doi: 10.1016/j.retram.2022.103338. PMID: 35217310
McLornan DP, Hargreaves R, Hernández-Boluda JC, Harrison CN
Br J Haematol 2022 May;197(4):407-416. Epub 2022 Feb 22 doi: 10.1111/bjh.18087. PMID: 35191542
Deschamps P, Moonim M, Radia D, Curto-Garcia N, Woodley C, Bassiony S, O'Sullivan J, Harrington P, Raj K, Francis Y, Kordasti S, Ali S, Harrison CN, McLornan DP
Br J Haematol 2021 May;193(4):792-797. Epub 2021 Mar 9 doi: 10.1111/bjh.17375. PMID: 33751548
Kim SY, Im K, Park SN, Kwon J, Kim JA, Lee DS
Am J Clin Pathol 2015 May;143(5):635-44. doi: 10.1309/AJCPUAAC16LIWZMM. PMID: 25873496
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Clinical prediction guides

Deschamps P, Moonim M, Radia D, Curto-Garcia N, Woodley C, Bassiony S, O'Sullivan J, Harrington P, Raj K, Francis Y, Kordasti S, Ali S, Harrison CN, McLornan DP
Br J Haematol 2021 May;193(4):792-797. Epub 2021 Mar 9 doi: 10.1111/bjh.17375. PMID: 33751548
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Kim SY, Im K, Park SN, Kwon J, Kim JA, Lee DS
Am J Clin Pathol 2015 May;143(5):635-44. doi: 10.1309/AJCPUAAC16LIWZMM. PMID: 25873496
Duletić AN, Dekanić A, Hadzisejdić I, Kusen I, Matusan-Ilijas K, Grohovac D, Grahovac B, Jonjić N
Coll Antropol 2012 Sep;36(3):859-65. PMID: 23213945
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

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