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Columnar Metaplasia

MedGen UID:
232385
•Concept ID:
C1333121
•
Finding

Definition

A morphologic finding indicating the transformation of non-columnar epithelial cells into columnar cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColumnar Metaplasia

Professional guidelines

PubMed

Management of Barrett's Esophagus.
Velanovich V
Am Surg 2012 Nov;78(11):1193-200. doi: 10.1177/000313481207801123. PMID: 23089433
Diagnosis and management of Barrett's esophagus.
Nelsen EM, Hawes RH, Iyer PG
Surg Clin North Am 2012 Oct;92(5):1135-54. Epub 2012 Aug 20 doi: 10.1016/j.suc.2012.07.009. PMID: 23026274Free PMC Article
Advances in endoscopic diagnosis and treatment of Barrett's esophagus.
Gaddam S, Sharma P
J Dig Dis 2010 Dec;11(6):323-33. doi: 10.1111/j.1751-2980.2010.00458.x. PMID: 21091894

Recent clinical studies

Etiology

Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Epidemiology and prevention of oesophageal adenocarcinoma.
Ness-Jensen E
Scand J Gastroenterol 2022 Aug;57(8):891-895. Epub 2022 Mar 2 doi: 10.1080/00365521.2022.2042594. PMID: 35234549
Columnar metaplasia in the esophageal remnant after esophagectomy: a systematic review.
Dunn LJ, Shenfine J, Griffin SM
Dis Esophagus 2015 Jan;28(1):32-41. Epub 2013 Nov 13 doi: 10.1111/dote.12129. PMID: 24224923
Controversies in Barrett esophagus.
Dunbar KB, Spechler SJ
Mayo Clin Proc 2014 Jul;89(7):973-84. Epub 2014 May 24 doi: 10.1016/j.mayocp.2014.01.022. PMID: 24867396
Management of Barrett's Esophagus.
Velanovich V
Am Surg 2012 Nov;78(11):1193-200. doi: 10.1177/000313481207801123. PMID: 23089433

Diagnosis

Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Some observations on Barrett esophagus and associated dysplasia.
Montgomery E, Arnold CA, Lam-Himlin D, Salimian K, Waters K
Ann Diagn Pathol 2018 Dec;37:75-82. Epub 2018 Sep 28 doi: 10.1016/j.anndiagpath.2018.09.013. PMID: 30312881
Short-segment and intrasphincteric gastroesophageal reflux.
McColl KE, Derakhshan MH, Mitchell DR
Curr Opin Gastroenterol 2016 Jul;32(4):332-7. doi: 10.1097/MOG.0000000000000273. PMID: 27276369
Controversies in Barrett esophagus.
Dunbar KB, Spechler SJ
Mayo Clin Proc 2014 Jul;89(7):973-84. Epub 2014 May 24 doi: 10.1016/j.mayocp.2014.01.022. PMID: 24867396
Diagnosis and management of Barrett's esophagus.
Nelsen EM, Hawes RH, Iyer PG
Surg Clin North Am 2012 Oct;92(5):1135-54. Epub 2012 Aug 20 doi: 10.1016/j.suc.2012.07.009. PMID: 23026274Free PMC Article

Therapy

Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Epidemiology and prevention of oesophageal adenocarcinoma.
Ness-Jensen E
Scand J Gastroenterol 2022 Aug;57(8):891-895. Epub 2022 Mar 2 doi: 10.1080/00365521.2022.2042594. PMID: 35234549
Columnar metaplasia in the esophageal remnant after esophagectomy: a systematic review.
Dunn LJ, Shenfine J, Griffin SM
Dis Esophagus 2015 Jan;28(1):32-41. Epub 2013 Nov 13 doi: 10.1111/dote.12129. PMID: 24224923
Diagnosis and management of Barrett's esophagus.
Nelsen EM, Hawes RH, Iyer PG
Surg Clin North Am 2012 Oct;92(5):1135-54. Epub 2012 Aug 20 doi: 10.1016/j.suc.2012.07.009. PMID: 23026274Free PMC Article
Are there unmet needs in acid suppression?
Tytgat GN
Best Pract Res Clin Gastroenterol 2004;18 Suppl:67-72. doi: 10.1016/j.bpg.2004.06.014. PMID: 15588797

Prognosis

Clinical Variables as Indicative Factors for Endoscopy in Adolescents with Esophageal Atresia.
Mikkelsen A, Møinichen UI, Reims HM, Grzyb K, Aabakken L, Mørkrid L, IJsselstijn H, Emblem R
J Pediatr Surg 2023 Aug;58(8):1421-1429. Epub 2022 Oct 19 doi: 10.1016/j.jpedsurg.2022.10.003. PMID: 36344284
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.
Naini BV, Souza RF, Odze RD
Am J Surg Pathol 2016 May;40(5):e45-66. doi: 10.1097/PAS.0000000000000598. PMID: 26813745Free PMC Article
Columnar Metaplasia in the Esophageal Remnant After Esophagectomy: A Common Occurrence and a Valuable Insight Into the Development of Barrett Esophagus.
Dunn LJ, Burt AD, Hayes N, Griffin SM
Ann Surg 2016 Dec;264(6):1016-1021. doi: 10.1097/SLA.0000000000001591. PMID: 26756755
Advances in understanding the pathogenesis of Barrett's esophagus.
Clemons NJ, Koh SY, Phillips WA
Discov Med 2014 Jan;17(91):7-14. PMID: 24411696
Field cancerization in Barrett's esophagus.
Zeki SS, McDonald SA, Graham TA
Discov Med 2011 Nov;12(66):371-9. PMID: 22127108

Clinical prediction guides

Clinical Variables as Indicative Factors for Endoscopy in Adolescents with Esophageal Atresia.
Mikkelsen A, Møinichen UI, Reims HM, Grzyb K, Aabakken L, Mørkrid L, IJsselstijn H, Emblem R
J Pediatr Surg 2023 Aug;58(8):1421-1429. Epub 2022 Oct 19 doi: 10.1016/j.jpedsurg.2022.10.003. PMID: 36344284
Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Barrett Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction in Children: A Clinicopathologic Study.
Putra J, Arva NC, Tan SY, Melin-Aldana H, Bass LM, Mitchell PD, Fox VL, Goldsmith JD
J Pediatr Gastroenterol Nutr 2020 May;70(5):562-567. doi: 10.1097/MPG.0000000000002640. PMID: 31977949
Some observations on Barrett esophagus and associated dysplasia.
Montgomery E, Arnold CA, Lam-Himlin D, Salimian K, Waters K
Ann Diagn Pathol 2018 Dec;37:75-82. Epub 2018 Sep 28 doi: 10.1016/j.anndiagpath.2018.09.013. PMID: 30312881
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.
Naini BV, Souza RF, Odze RD
Am J Surg Pathol 2016 May;40(5):e45-66. doi: 10.1097/PAS.0000000000000598. PMID: 26813745Free PMC Article

Recent systematic reviews

The global prevalence of Barrett's esophagus: A systematic review of the published literature.
Marques de Sá I, Marcos P, Sharma P, Dinis-Ribeiro M
United European Gastroenterol J 2020 Nov;8(9):1086-1105. Epub 2020 Jul 6 doi: 10.1177/2050640620939376. PMID: 32631176Free PMC Article
Columnar metaplasia in the esophageal remnant after esophagectomy: a systematic review.
Dunn LJ, Shenfine J, Griffin SM
Dis Esophagus 2015 Jan;28(1):32-41. Epub 2013 Nov 13 doi: 10.1111/dote.12129. PMID: 24224923

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