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Conventional leiomyosarcoma

MedGen UID:
232394
Concept ID:
C1333157
Neoplastic Process
Synonyms: Classic Leiomyosarcoma; classic leiomyosarcoma; Conventional Leiomyosarcoma; conventional leiomyosarcoma
 
Monarch Initiative: MONDO:0003348

Definition

An uncommon, aggressive malignant smooth muscle neoplasm. It is characterized by the presence of atypical large spindle or round cells, nuclear palisading, tumor cell necrosis, mitotic figures and may be associated with vascular invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConventional leiomyosarcoma

Professional guidelines

PubMed

Kasper B, D'Ambrosio L, Davis EJ, Ingham M, Broto JM, Trent JC, van Houdt WJ, Van Tine BA
Curr Treat Options Oncol 2022 Mar;23(3):439-449. Epub 2022 Mar 11 doi: 10.1007/s11864-021-00928-y. PMID: 35275323Free PMC Article
Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279
Salti GI, Ailabouni L, Undevia S
Ann Surg Oncol 2012 May;19(5):1410-5. doi: 10.1245/s10434-012-2240-7. PMID: 22302269

Recent clinical studies

Diagnosis

Kim JY, Kim B
Am J Case Rep 2023 May 16;24:e939349. doi: 10.12659/AJCR.939349. PMID: 37190674Free PMC Article
Natsume T, Yoshida H, Nishikawa T, Kikkawa N, Naka T, Kobayashi-Kato M, Tanase Y, Uno M, Ishikawa M, Kato T
Int J Surg Pathol 2023 Aug;31(5):778-784. Epub 2022 Oct 31 doi: 10.1177/10668969221133348. PMID: 36310451
Michal M, Rubin BP, Kazakov DV, Michalová K, Šteiner P, Grossmann P, Hájková V, Martínek P, Švajdler M, Agaimy A, Hadravský L, Kalmykova AV, Konishi E, Heidenreich F, Michal M
Virchows Arch 2020 Aug;477(2):219-230. Epub 2020 Feb 20 doi: 10.1007/s00428-020-02774-z. PMID: 32078043
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Sukpan K, Khunamornpong S, Suprasert P, Siriaunkgul S
J Med Assoc Thai 2010 Apr;93(4):510-5. PMID: 20462098

Prognosis

Wei S, Pei J, Belser P, Lee T, Farma JM, Patchefsky AS, Flieder DB, Montgomery EA
Genes Chromosomes Cancer 2024 Apr;63(4):e23239. doi: 10.1002/gcc.23239. PMID: 38656544
Kim JY, Kim B
Am J Case Rep 2023 May 16;24:e939349. doi: 10.12659/AJCR.939349. PMID: 37190674Free PMC Article
Michal M, Rubin BP, Kazakov DV, Michalová K, Šteiner P, Grossmann P, Hájková V, Martínek P, Švajdler M, Agaimy A, Hadravský L, Kalmykova AV, Konishi E, Heidenreich F, Michal M
Virchows Arch 2020 Aug;477(2):219-230. Epub 2020 Feb 20 doi: 10.1007/s00428-020-02774-z. PMID: 32078043
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Sukpan K, Khunamornpong S, Suprasert P, Siriaunkgul S
J Med Assoc Thai 2010 Apr;93(4):510-5. PMID: 20462098

Clinical prediction guides

Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Wincewicz A, Kowalik A, Zięba S, Góźdź S, Woltanowska M
Rom J Morphol Embryol 2016;57(4):1409-1414. PMID: 28174812

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