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Conventional leiomyosarcoma

MedGen UID:
232394
•Concept ID:
C1333157
•
Neoplastic Process
Synonyms: Classic Leiomyosarcoma; classic leiomyosarcoma; Conventional Leiomyosarcoma; conventional leiomyosarcoma
 
Monarch Initiative: MONDO:0003348

Definition

An uncommon, aggressive malignant smooth muscle neoplasm. It is characterized by the presence of atypical large spindle or round cells, nuclear palisading, tumor cell necrosis, mitotic figures and may be associated with vascular invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConventional leiomyosarcoma

Professional guidelines

PubMed

What Clinical Trials Are Needed for Treatment of Leiomyosarcoma?
Kasper B, D'Ambrosio L, Davis EJ, Ingham M, Broto JM, Trent JC, van Houdt WJ, Van Tine BA
Curr Treat Options Oncol 2022 Mar;23(3):439-449. Epub 2022 Mar 11 doi: 10.1007/s11864-021-00928-y. PMID: 35275323Free PMC Article
Efficacy of Hyperthermic Intraperitoneal Chemotherapy and Cytoreductive Surgery in the Treatment of Recurrent Uterine Sarcoma.
Díaz-Montes TP, El-Sharkawy F, Lynam S, Harper A, Sittig M, MacDonald R, Gushchin V, Sardi A
Int J Gynecol Cancer 2018 Jul;28(6):1130-1137. doi: 10.1097/IGC.0000000000001289. PMID: 29975291
Myxoid Mesenchymal Tumors of the Uterus: An Update on Classification, Definitions, and Differential Diagnosis.
Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279

Recent clinical studies

Diagnosis

Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report.
Kim JY, Kim B
Am J Case Rep 2023 May 16;24:e939349. doi: 10.12659/AJCR.939349. PMID: 37190674Free PMC Article
Uterine Leiomyosarcoma Masquerading as a Malignant Perivascular Epithelioid Cell Tumor: A Diagnostic Challenge.
Natsume T, Yoshida H, Nishikawa T, Kikkawa N, Naka T, Kobayashi-Kato M, Tanase Y, Uno M, Ishikawa M, Kato T
Int J Surg Pathol 2023 Aug;31(5):778-784. Epub 2022 Oct 31 doi: 10.1177/10668969221133348. PMID: 36310451
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.
Michal M, Rubin BP, Kazakov DV, Michalová K, Šteiner P, Grossmann P, Hájková V, Martínek P, Švajdler M, Agaimy A, Hadravský L, Kalmykova AV, Konishi E, Heidenreich F, Michal M
Virchows Arch 2020 Aug;477(2):219-230. Epub 2020 Feb 20 doi: 10.1007/s00428-020-02774-z. PMID: 32078043
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases.
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review.
Sukpan K, Khunamornpong S, Suprasert P, Siriaunkgul S
J Med Assoc Thai 2010 Apr;93(4):510-5. PMID: 20462098

Prognosis

Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report.
Kim JY, Kim B
Am J Case Rep 2023 May 16;24:e939349. doi: 10.12659/AJCR.939349. PMID: 37190674Free PMC Article
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.
Michal M, Rubin BP, Kazakov DV, Michalová K, Šteiner P, Grossmann P, Hájková V, Martínek P, Švajdler M, Agaimy A, Hadravský L, Kalmykova AV, Konishi E, Heidenreich F, Michal M
Virchows Arch 2020 Aug;477(2):219-230. Epub 2020 Feb 20 doi: 10.1007/s00428-020-02774-z. PMID: 32078043
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases.
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review.
Sukpan K, Khunamornpong S, Suprasert P, Siriaunkgul S
J Med Assoc Thai 2010 Apr;93(4):510-5. PMID: 20462098
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity.
Chang A, Schuetze SM, Conrad EU 3rd, Swisshelm KL, Norwood TH, Rubin BP
Int J Surg Pathol 2005 Apr;13(2):185-95. doi: 10.1177/106689690501300210. PMID: 15864383

Clinical prediction guides

Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases.
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling.
Wincewicz A, Kowalik A, Zięba S, Góźdź S, Woltanowska M
Rom J Morphol Embryol 2016;57(4):1409-1414. PMID: 28174812

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