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Corneal intraepithelial neoplasm

MedGen UID:
232396
•Concept ID:
C1333159
•
Neoplastic Process
Synonyms: CIN - corneal intraepithelial neoplasia; Cornea Intraepithelial Neoplasia; cornea intraepithelial neoplasia; cornea squamous cell intraepithelial neoplasia; Corneal intraepithelial neoplasia; Corneal Intraepithelial Neoplasia; corneal intraepithelial neoplasia; corneal intraepithelial neoplasm; Corneal Squamous Intraepithelial Neoplasia; Intraepithelial Neoplasia of Cornea; intraepithelial neoplasia of cornea; Intraepithelial Neoplasia of the Cornea; intraepithelial neoplasia of the cornea
SNOMED CT: Corneal intraepithelial neoplasia (420835009); CIN - corneal intraepithelial neoplasia (420835009)
 
Monarch Initiative: MONDO:0003801

Definition

A precancerous neoplastic intraepithelial process involving the corneal epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal intraepithelial neoplasm

Professional guidelines

PubMed

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology.
Oliveira GG, Oliveira JMDSC, Eleutério RMN, Barbosa RCC, Almeida PRC, Eleutério J Jr
Acta Cytol 2018;62(5-6):386-392. Epub 2018 Jun 13 doi: 10.1159/000489386. PMID: 29898441
Conjunctival Squamous Neoplasia: Staging and Initial Treatment.
Bellerive C, Berry JL, Polski A, Singh AD
Cornea 2018 Oct;37(10):1287-1291. doi: 10.1097/ICO.0000000000001651. PMID: 29863543Free PMC Article
Management of diffuse ocular surface squamous neoplasia: efficacy and complications of topical chemotherapy.
Rudkin AK, Dempster L, Muecke JS
Clin Exp Ophthalmol 2015 Jan-Feb;43(1):20-5. Epub 2014 Sep 9 doi: 10.1111/ceo.12377. PMID: 24995542

Recent clinical studies

Etiology

Safety and efficacy of topical interferon alpha 2B and mitomycin C for localized conjunctival intraepithelial neoplasia: long-term report of their pharmacological safety and efficacy.
Alvarado-Castillo B, Santa Cruz-Pavlovich FJ, Gonzalez-Castillo C, Vidal-Paredes IA, Garcia-Benavides L, Rosales-Gradilla ME, Navarro-Partida J
BMC Ophthalmol 2023 Jul 27;23(1):335. doi: 10.1186/s12886-023-03092-z. PMID: 37501105Free PMC Article
Primary Mucoepidermoid Carcinoma of the Lacrimal Apparatus.
Sun H, Cai R, Zhai C, Song W, Sun J, Bi Y
Am J Ophthalmol 2022 Jul;239:170-179. Epub 2022 Mar 12 doi: 10.1016/j.ajo.2022.03.008. PMID: 35288069
The treatment of recurrent conjunctival and corneal intraepithelial neoplasia with interferon alfa-2b and retinoic acid: ~9 years' follow-up on tumor control.
Ip MH, Tat L, Coroneo MT
Ocul Surf 2020 Jul;18(3):354-359. Epub 2020 Apr 18 doi: 10.1016/j.jtos.2020.04.004. PMID: 32311432
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Management of intraepithelial and invasive neoplasia of the cornea and conjunctiva: a long-term follow up.
Zaki AA, Farid SF
Cornea 2009 Oct;28(9):986-8. doi: 10.1097/ICO.0b013e3181a0a23d. PMID: 19724215

Diagnosis

An Unusual Presentation of Corneal Intraepithelial Neoplasia: A Case Report.
Bajracharya L, Sapkota J
Nepal J Ophthalmol 2022 Jan;14(27):178-182. doi: 10.3126/nepjoph.v14i1.39806. PMID: 35996917
Corneal Epithelial Thickness Mapping in the Diagnosis of Ocular Surface Disorders Involving the Corneal Epithelium: A Comparative Study.
Levy A, Georgeon C, Knoeri J, Tourabaly M, Leveziel L, Bouheraoua N, Borderie VM
Cornea 2022 Nov 1;41(11):1353-1361. Epub 2022 Mar 30 doi: 10.1097/ICO.0000000000003012. PMID: 35349542Free PMC Article
Primary Mucoepidermoid Carcinoma of the Lacrimal Apparatus.
Sun H, Cai R, Zhai C, Song W, Sun J, Bi Y
Am J Ophthalmol 2022 Jul;239:170-179. Epub 2022 Mar 12 doi: 10.1016/j.ajo.2022.03.008. PMID: 35288069
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Prostate lesions with cribriform / pseudocribriform pattern.
Dema A, Borda A, Lazăr E, Lăzureanu C, Tăban S, Anderco D, Cornianu M, Mureşan A, Herman D, Loghin A, Cornea R, Faur A
Rom J Morphol Embryol 2010;51(3):413-25. PMID: 20809015

Therapy

A Man With a Cloudy Cornea.
Ocran C, Harmsen H, Shieh C
JAMA Ophthalmol 2021 Feb 1;139(2):238-239. doi: 10.1001/jamaophthalmol.2020.4646. PMID: 33355628
Retinoic acid and the ocular surface.
Samarawickrama C, Chew S, Watson S
Surv Ophthalmol 2015 May-Jun;60(3):183-95. Epub 2014 Oct 16 doi: 10.1016/j.survophthal.2014.10.001. PMID: 25890622
Topical chemotherapy for ocular surface squamous neoplasia.
Nanji AA, Sayyad FE, Karp CL
Curr Opin Ophthalmol 2013 Jul;24(4):336-42. doi: 10.1097/ICU.0b013e3283622a13. PMID: 23680759
Management of intraepithelial and invasive neoplasia of the cornea and conjunctiva: a long-term follow up.
Zaki AA, Farid SF
Cornea 2009 Oct;28(9):986-8. doi: 10.1097/ICO.0b013e3181a0a23d. PMID: 19724215
Topical medical therapies for ocular surface tumors.
Poothullil AM, Colby KA
Semin Ophthalmol 2006 Jul-Sep;21(3):161-9. doi: 10.1080/08820530500351694. PMID: 16912014

Prognosis

An Unusual Presentation of Corneal Intraepithelial Neoplasia: A Case Report.
Bajracharya L, Sapkota J
Nepal J Ophthalmol 2022 Jan;14(27):178-182. doi: 10.3126/nepjoph.v14i1.39806. PMID: 35996917
Primary Mucoepidermoid Carcinoma of the Lacrimal Apparatus.
Sun H, Cai R, Zhai C, Song W, Sun J, Bi Y
Am J Ophthalmol 2022 Jul;239:170-179. Epub 2022 Mar 12 doi: 10.1016/j.ajo.2022.03.008. PMID: 35288069
Prostate lesions with cribriform / pseudocribriform pattern.
Dema A, Borda A, Lazăr E, Lăzureanu C, Tăban S, Anderco D, Cornianu M, Mureşan A, Herman D, Loghin A, Cornea R, Faur A
Rom J Morphol Embryol 2010;51(3):413-25. PMID: 20809015
Management of intraepithelial and invasive neoplasia of the cornea and conjunctiva: a long-term follow up.
Zaki AA, Farid SF
Cornea 2009 Oct;28(9):986-8. doi: 10.1097/ICO.0b013e3181a0a23d. PMID: 19724215
Conjunctival and corneal intraepithelial and invasive neoplasia.
Erie JC, Campbell RJ, Liesegang TJ
Ophthalmology 1986 Feb;93(2):176-83. doi: 10.1016/s0161-6420(86)33764-3. PMID: 3951824

Clinical prediction guides

Primary Mucoepidermoid Carcinoma of the Lacrimal Apparatus.
Sun H, Cai R, Zhai C, Song W, Sun J, Bi Y
Am J Ophthalmol 2022 Jul;239:170-179. Epub 2022 Mar 12 doi: 10.1016/j.ajo.2022.03.008. PMID: 35288069
Could Extension Into the Lacrimal Gland and Sac Thwart Topical Chemotherapy for Intraepithelial Sebaceous Carcinoma?
Gupta T, Vahdani K, Rose GE, Luthert PJ, Daniel C, Verity DH
Ophthalmic Plast Reconstr Surg 2022 Jan-Feb 01;38(1):17-21. doi: 10.1097/IOP.0000000000001960. PMID: 33782326
The treatment of recurrent conjunctival and corneal intraepithelial neoplasia with interferon alfa-2b and retinoic acid: ~9 years' follow-up on tumor control.
Ip MH, Tat L, Coroneo MT
Ocul Surf 2020 Jul;18(3):354-359. Epub 2020 Apr 18 doi: 10.1016/j.jtos.2020.04.004. PMID: 32311432
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Clinical and pathologic description of 17 cases of corneal intraepithelial neoplasia.
Waring GO 3rd, Roth AM, Ekins MB
Am J Ophthalmol 1984 May;97(5):547-59. doi: 10.1016/0002-9394(84)90371-4. PMID: 6720832

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