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FIGO Stage IV Gestational Trophoblastic Tumor

MedGen UID:
232496
•Concept ID:
C1333563
•
Neoplastic Process

Definition

Gestational trophoblastic tumor in all other metastatic sites. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Results of treatment of gestational trophoblastic neoplasia in the Slovak Republic in the years 1993-2017.
Korbeľ Miroslav, Šufliarsky Jozef, Danihel Ľudovít, Nižňanská Zuzana
Ceska Gynekol 2021;86(2):94-101. doi: 10.48095/cccg202194. PMID: 34020555
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Recent clinical studies

Etiology

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia: experience at Salah Azaiez Institute.
Batti R, Mokrani A, Rachdi H, Raies H, Touhami O, Ayadi M, Meddeb K, Letaief F, Yahiaoui Y, Chraiet N, Mezlini A
Pan Afr Med J 2019;33:121. Epub 2019 Jun 17 doi: 10.11604/pamj.2019.33.121.13897. PMID: 31489099Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654

Diagnosis

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia: experience at Salah Azaiez Institute.
Batti R, Mokrani A, Rachdi H, Raies H, Touhami O, Ayadi M, Meddeb K, Letaief F, Yahiaoui Y, Chraiet N, Mezlini A
Pan Afr Med J 2019;33:121. Epub 2019 Jun 17 doi: 10.11604/pamj.2019.33.121.13897. PMID: 31489099Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654

Therapy

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Real-World Study of Cisplatin, Etoposide, and Bleomycin Chemotherapy Regimen in Gestational Trophoblastic Neoplasia.
Wang M, Shen L, Xu X, Duan W, Miao J, Kong W, Su L, Wu Y
Biomed Res Int 2021;2021:6661698. Epub 2021 Jun 24 doi: 10.1155/2021/6661698. PMID: 34258277Free PMC Article
Management and prognostic analysis of patients with gestational trophoblastic neoplasia (GTN) in FIGO stage IV and its special type.
Wang K, Chen Y
Clin Exp Metastasis 2021 Feb;38(1):47-59. Epub 2020 Nov 20 doi: 10.1007/s10585-020-10064-w. PMID: 33219408Free PMC Article
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654
Treatment of gestational trophoblastic tumors.
Lurain JR
Curr Treat Options Oncol 2002 Apr;3(2):113-24. doi: 10.1007/s11864-002-0057-5. PMID: 12057074

Prognosis

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Management and prognostic analysis of patients with gestational trophoblastic neoplasia (GTN) in FIGO stage IV and its special type.
Wang K, Chen Y
Clin Exp Metastasis 2021 Feb;38(1):47-59. Epub 2020 Nov 20 doi: 10.1007/s10585-020-10064-w. PMID: 33219408Free PMC Article
Gestational trophoblastic neoplasia: experience at Salah Azaiez Institute.
Batti R, Mokrani A, Rachdi H, Raies H, Touhami O, Ayadi M, Meddeb K, Letaief F, Yahiaoui Y, Chraiet N, Mezlini A
Pan Afr Med J 2019;33:121. Epub 2019 Jun 17 doi: 10.11604/pamj.2019.33.121.13897. PMID: 31489099Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome.
Hyman DM, Bakios L, Gualtiere G, Carr C, Grisham RN, Makker V, Sonoda Y, Aghajanian C, Jewell EL
Gynecol Oncol 2013 Apr;129(1):58-62. Epub 2012 Dec 26 doi: 10.1016/j.ygyno.2012.12.029. PMID: 23274560

Clinical prediction guides

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia: experience at Salah Azaiez Institute.
Batti R, Mokrani A, Rachdi H, Raies H, Touhami O, Ayadi M, Meddeb K, Letaief F, Yahiaoui Y, Chraiet N, Mezlini A
Pan Afr Med J 2019;33:121. Epub 2019 Jun 17 doi: 10.11604/pamj.2019.33.121.13897. PMID: 31489099Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654

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