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Digestive System Non-Hodgkin Lymphoma

MedGen UID:: 232554
•Concept ID:: C1333800
•: Neoplastic Process

Synonyms:

Gastrointestinal Non-Hodgkin Lymphoma; Gastrointestinal Non-Hodgkin's Lymphoma; Primary Digestive System Non-Hodgkin Lymphoma; Primary Gastrointestinal Non-Hodgkin's Lymphoma

Definition

A non-Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDigestive System Non-Hodgkin Lymphoma

Hematopoietic and Lymphoid System Disorder
- Hematologic disorder
  - Hematologic neoplasm
    - Lymphoma
      - Lymphoma by Site
        Gastrointestinal lymphoma
        Digestive System Non-Hodgkin Lymphoma
        AIDS-Related Anal Non-Hodgkin Lymphoma
        Colorectal Non-Hodgkin Lymphoma
        Colon Non-Hodgkin Lymphoma
        Cecum Non-Hodgkin Lymphoma
        Colon Burkitt lymphoma
        Colon Diffuse Large B-Cell Lymphoma
        Colon Mantle Cell Lymphoma
        Colon mucosa-associated lymphoid tissue lymphoma
        Colorectal Burkitt Lymphoma
        Colorectal diffuse large B-cell lymphoma
        Colorectal High Grade B-Cell Lymphoma, Not Otherwise Specified
        Colorectal Mantle Cell Lymphoma
        Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma
        Digestive System Diffuse Large B-Cell Lymphoma
        Esophageal Diffuse Large B-Cell Lymphoma
        Gastric diffuse large B-cell lymphoma
        Liver diffuse large B-cell lymphoma
        Small intestinal diffuse large B-cell lymphoma
        Small Intestinal High Grade B-Cell Lymphoma, Not Otherwise Specified
        Esophageal Non-Hodgkin Lymphoma
        Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma
        Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System
        Gastric mucosa-associated lymphoid tissue lymphoma
        Helicobacter Pylori-Associated Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
        Liver Mucosa-Associated Lymphoid Tissue Lymphoma
        Small intestinal mucosa-associated lymphoid tissue lymphoma
        Campylobacter Jejuni-Associated Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma
        Gastric non-hodgkin lymphoma
        Gastric Burkitt Lymphoma
        Gastric T-Cell Non-Hodgkin Lymphoma
        Intestinal Follicular Lymphoma
        Small Intestinal Follicular Lymphoma
        Intestinal T-Cell Lymphoma
        Enteropathy-associated T-cell lymphoma
        Enteropathy-Associated T-Cell Lymphoma by Ann Arbor Stage
        Recurrent Enteropathy-Associated T-Cell Lymphoma
        Refractory Enteropathy-Associated T-Cell Lymphoma
        Small intestinal enteropathy-associated T-cell lymphoma
        Intestinal T-Cell Lymphoma, Not Otherwise Specified
        Monomorphic epitheliotropic intestinal T-cell lymphoma
        Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
        Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
        Small Intestinal Monomorphic Epitheliotropic T-Cell Lymphoma
        Liver Non-Hodgkin Lymphoma
        Hepatosplenic T-cell lymphoma
        Recurrent Hepatosplenic T-Cell Lymphoma
        Refractory Hepatosplenic T-Cell Lymphoma
        Multifocal Lymphomatous Polyposis
        Pancreatic Non-Hodgkin Lymphoma
        Small Intestinal Non-Hodgkin Lymphoma
        Small Intestinal B-Cell Non-Hodgkin Lymphoma
        Alpha-heavy chain disease
        Small intestinal Burkitt lymphoma
        Small Intestinal Mantle Cell Lymphoma
        Small Intestinal T-Cell Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Advances in diagnosis, treatment and prognostic factors of gastrointestinal DLBCL.

Lai Q, Zhao Y, Yan H, Peng H
Leuk Res 2023 Dec;135:107406. Epub 2023 Oct 18 doi: 10.1016/j.leukres.2023.107406. PMID: 37944240

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.

Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999

Review of lymphoma in the duodenum: An update of diagnosis and management.

Iwamuro M, Tanaka T, Okada H
World J Gastroenterol 2023 Mar 28;29(12):1852-1862. doi: 10.3748/wjg.v29.i12.1852. PMID: 37032723 Free PMC Article

See all (99)

Recent clinical studies

Etiology

Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study.

Xu R, Zheng T, Ouyang C, Ding X, Ge C
Front Endocrinol (Lausanne) 2023;14:1110523. Epub 2023 Feb 13 doi: 10.3389/fendo.2023.1110523. PMID: 36860363 Free PMC Article

Extranodal T- and NK-cell lymphomas.

de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765 Free PMC Article

Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.

Vithayathil M, Carter P, Kar S, Mason AM, Burgess S, Larsson SC
PLoS Med 2021 Jul;18(7):e1003706. Epub 2021 Jul 29 doi: 10.1371/journal.pmed.1003706. PMID: 34324486 Free PMC Article

Gastrointestinal lymphoproliferative lesions: a practical diagnostic approach.

Pizzi M, Sabattini E, Parente P, Bellan A, Doglioni C, Lazzi S
Pathologica 2020 Sep;112(3):227-247. doi: 10.32074/1591-951X-161. PMID: 33179624 Free PMC Article

Primary Sjögren's syndrome.

Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

See all (703)

Diagnosis

Gastrointestinal lymphoproliferative lesions: a practical diagnostic approach.

Pizzi M, Sabattini E, Parente P, Bellan A, Doglioni C, Lazzi S
Pathologica 2020 Sep;112(3):227-247. doi: 10.32074/1591-951X-161. PMID: 33179624 Free PMC Article

Upfront Surgery for Small Intestinal Non-Hodgkin's Lymphoma.

Iida T, Nozawa H, Sonoda H, Toyama K, Kawai K, Hata K, Tanaka T, Nishikawa T, Sasaki K, Shuno Y, Kaneko M, Murono K, Emoto S, Ishii H, Kurokawa M, Ishihara S
Anticancer Res 2020 Apr;40(4):2373-2377. doi: 10.21873/anticanres.14206. PMID: 32234940

Non-Hodgkin's lymphoma of the oral cavity and maxillofacial region: a pathologist viewpoint.

Abdelwahed Hussein MR
Expert Rev Hematol 2018 Sep;11(9):737-748. Epub 2018 Aug 21 doi: 10.1080/17474086.2018.1506326. PMID: 30058399

Celiac disease.

Rodrigo L
World J Gastroenterol 2006 Nov 7;12(41):6585-93. doi: 10.3748/wjg.v12.i41.6585. PMID: 17075969 Free PMC Article

Neutropenic enterocolitis.

Davila ML
Curr Opin Gastroenterol 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b. PMID: 16319675

See all (1528)

Therapy

Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study.

Xu R, Zheng T, Ouyang C, Ding X, Ge C
Front Endocrinol (Lausanne) 2023;14:1110523. Epub 2023 Feb 13 doi: 10.3389/fendo.2023.1110523. PMID: 36860363 Free PMC Article

Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.

Vithayathil M, Carter P, Kar S, Mason AM, Burgess S, Larsson SC
PLoS Med 2021 Jul;18(7):e1003706. Epub 2021 Jul 29 doi: 10.1371/journal.pmed.1003706. PMID: 34324486 Free PMC Article

Gamma-delta t-cell lymphomas.

Foppoli M, Ferreri AJ
Eur J Haematol 2015 Mar;94(3):206-18. Epub 2014 Oct 1 doi: 10.1111/ejh.12439. PMID: 25154298

Celiac disease.

Rodrigo L
World J Gastroenterol 2006 Nov 7;12(41):6585-93. doi: 10.3748/wjg.v12.i41.6585. PMID: 17075969 Free PMC Article

Neutropenic enterocolitis.

Davila ML
Curr Opin Gastroenterol 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b. PMID: 16319675

See all (629)

Prognosis

Appendix Tumor Microenvironment.

Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678

Non-Hodgkin's lymphoma of the oral cavity and maxillofacial region: a pathologist viewpoint.

Abdelwahed Hussein MR
Expert Rev Hematol 2018 Sep;11(9):737-748. Epub 2018 Aug 21 doi: 10.1080/17474086.2018.1506326. PMID: 30058399

Primary Gastrointestinal Non-Hodgkin's Lymphoma of the Small and Large Intestines: a Systematic Review.

Lightner AL, Shannon E, Gibbons MM, Russell MM
J Gastrointest Surg 2016 Apr;20(4):827-39. Epub 2015 Dec 16 doi: 10.1007/s11605-015-3052-4. PMID: 26676930

Neutropenic enterocolitis.

Davila ML
Curr Opin Gastroenterol 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b. PMID: 16319675

Non-Hodgkin lymphomas.

Jones SE
JAMA 1975 Nov 10;234(6):633-8. PMID: 1100872

See all (735)

Clinical prediction guides

Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study.

Xu R, Zheng T, Ouyang C, Ding X, Ge C
Front Endocrinol (Lausanne) 2023;14:1110523. Epub 2023 Feb 13 doi: 10.3389/fendo.2023.1110523. PMID: 36860363 Free PMC Article

Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.

Vithayathil M, Carter P, Kar S, Mason AM, Burgess S, Larsson SC
PLoS Med 2021 Jul;18(7):e1003706. Epub 2021 Jul 29 doi: 10.1371/journal.pmed.1003706. PMID: 34324486 Free PMC Article

Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: An update.

Wagner VP, Rodrigues-Fernandes CI, Carvalho MVR, Dos Santos JN, Barra MB, Hunter KD, Aguirre-Urizar JM, van Heerden WFP, Vargas PA, Fonseca FP, Martins MD
J Oral Pathol Med 2021 Jul;50(6):622-630. Epub 2021 Jul 1 doi: 10.1111/jop.13214. PMID: 34101256

Appendix Tumor Microenvironment.

Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678

Predicting lymphoma development in patients with Sjögren's syndrome.

De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413

See all (409)

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.

Lymphomas of the salivary glands: a systematic review.

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309

Gastrosplenic fistula occurring in lymphoma patients: Systematic review with a new case of extranodal NK/T-cell lymphoma.

Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ
World J Gastroenterol 2017 Sep 21;23(35):6491-6499. doi: 10.3748/wjg.v23.i35.6491. PMID: 29085199 Free PMC Article

Primary Gastrointestinal Non-Hodgkin's Lymphoma of the Small and Large Intestines: a Systematic Review.

Lightner AL, Shannon E, Gibbons MM, Russell MM
J Gastrointest Surg 2016 Apr;20(4):827-39. Epub 2015 Dec 16 doi: 10.1007/s11605-015-3052-4. PMID: 26676930

Primary low-grade and high-grade gastric MALT-lymphoma presentation.

Zullo A, Hassan C, Andriani A, Cristofari F, Cardinale V, Spinelli GP, Tomao S, Morini S
J Clin Gastroenterol 2010 May-Jun;44(5):340-4. doi: 10.1097/MCG.0b013e3181b4b1ab. PMID: 19745757

See all (8)

MedGen

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Digestive System Non-Hodgkin Lymphoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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