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Gingival Angiofibroma

MedGen UID:
232556
•Concept ID:
C1333818
•
Neoplastic Process

Definition

A benign neoplasm arising from the fibrous soft tissues of the gingiva. It is characterized by the presence of spindle-shaped fibroblasts and numerous dilated vascular channels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGingival Angiofibroma

Recent clinical studies

Etiology

Gingival enlargement as a manifestation of tuberous sclerosis: case report and periodontal management.
Korol UB, Schoor R, Nanda V, Almas K, Phelan JA
J Periodontol 2008 Apr;79(4):759-63. doi: 10.1902/jop.2008.070407. PMID: 18380572

Diagnosis

Bannayan-Riley-Ruvalcaba syndrome with gingival hyperpigmentation and facial papules.
Niklinska EB, Lyons EM, Hicks A, Zwerner JP, Albers SE
Pediatr Dermatol 2021 Sep;38(5):1351-1353. Epub 2021 Jul 14 doi: 10.1111/pde.14691. PMID: 34259361
Clinicopathological investigation of odontogenic fibroma in tuberous sclerosis complex.
Musha A, Yokoo S, Takayama Y, Sato H
Int J Oral Maxillofac Surg 2018 Jul;47(7):918-922. Epub 2018 Apr 10 doi: 10.1016/j.ijom.2018.03.025. PMID: 29653868
Tuberous Sclerosis Complex with Gingival Enlargement in an Adolescent.
Nath S, Prakash J, Singh NN, Prajapati VK
J Coll Physicians Surg Pak 2018 Mar;28(3):S16-S18. doi: 10.29271/jcpsp.2018.03.S16. PMID: 29482692
Oral and neurocutaneous phenotypes of familial tuberous sclerosis.
Araujo Lde J, Lima LS, Alvarenga TM, Martelli-Júnior H, Coletta RD, de Aquino SN, Bonan PR
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jan;111(1):87-94. Epub 2010 Nov 4 doi: 10.1016/j.tripleo.2010.07.002. PMID: 21055980
Gingival enlargement as a manifestation of tuberous sclerosis: case report and periodontal management.
Korol UB, Schoor R, Nanda V, Almas K, Phelan JA
J Periodontol 2008 Apr;79(4):759-63. doi: 10.1902/jop.2008.070407. PMID: 18380572

Therapy

Tuberous sclerosis: histological analysis with confocal laser scanning microscope of gingival angiofibromatosis.
Favia G, Tempesta A, Limongelli L, Maiorano E
Pathologica 2015 Sep-Dec;107(3-4):197-200. PMID: 26946876

Prognosis

Clinicopathological investigation of odontogenic fibroma in tuberous sclerosis complex.
Musha A, Yokoo S, Takayama Y, Sato H
Int J Oral Maxillofac Surg 2018 Jul;47(7):918-922. Epub 2018 Apr 10 doi: 10.1016/j.ijom.2018.03.025. PMID: 29653868
Gingival enlargement as a manifestation of tuberous sclerosis: case report and periodontal management.
Korol UB, Schoor R, Nanda V, Almas K, Phelan JA
J Periodontol 2008 Apr;79(4):759-63. doi: 10.1902/jop.2008.070407. PMID: 18380572

Clinical prediction guides

Tuberous sclerosis: histological analysis with confocal laser scanning microscope of gingival angiofibromatosis.
Favia G, Tempesta A, Limongelli L, Maiorano E
Pathologica 2015 Sep-Dec;107(3-4):197-200. PMID: 26946876
Evaluation of MMP-1, MMP-10, TIMP-1, a-SMA and TGF-b1 in angiofibromas of tuberous sclerosis.
De Jesus Araújo L, Yamamoto De Almeida L, Santos Lima J, Martelli-Júnior H, Ferreti Bonan PR
Minerva Stomatol 2011 Jan-Feb;60(1-2):25-33. PMID: 21252847
Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.
Darling TN, Skarulis MC, Steinberg SM, Marx SJ, Spiegel AM, Turner M
Arch Dermatol 1997 Jul;133(7):853-7. PMID: 9236523

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