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Head and Neck Precancerous Condition

MedGen UID:
232589
Concept ID:
C1333945
Disease or Syndrome

Definition

A premalignant pathologic process that affects the anatomic structures of the head and neck. Representative examples include oral leukoplakia and leukoplakia of the vocal cords. [from NCI]

Professional guidelines

PubMed

Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Recent clinical studies

Etiology

Chen K, Bai J, Reuben A, Zhao H, Kang G, Zhang C, Qi Q, Xu Y, Hubert S, Chang L, Guan Y, Feng L, Zhang K, Zhang K, Yi X, Xia X, Cheng S, Yang F, Zhang J, Wang J
Am J Respir Crit Care Med 2021 Nov 15;204(10):1180-1192. doi: 10.1164/rccm.202101-0119OC. PMID: 34473939Free PMC Article
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article

Diagnosis

Chen K, Bai J, Reuben A, Zhao H, Kang G, Zhang C, Qi Q, Xu Y, Hubert S, Chang L, Guan Y, Feng L, Zhang K, Zhang K, Yi X, Xia X, Cheng S, Yang F, Zhang J, Wang J
Am J Respir Crit Care Med 2021 Nov 15;204(10):1180-1192. doi: 10.1164/rccm.202101-0119OC. PMID: 34473939Free PMC Article
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, Plotnikov A, Barr H, Tsherniak A, Rozenblatt-Rosen O, Krizhanovsky V, Puram SV, Regev A, Tirosh I
Nat Genet 2020 Nov;52(11):1208-1218. Epub 2020 Oct 30 doi: 10.1038/s41588-020-00726-6. PMID: 33128048Free PMC Article
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Therapy

Han G, Sinjab A, Rahal Z, Lynch AM, Treekitkarnmongkol W, Liu Y, Serrano AG, Feng J, Liang K, Khan K, Lu W, Hernandez SD, Liu Y, Cao X, Dai E, Pei G, Hu J, Abaya C, Gomez-Bolanos LI, Peng F, Chen M, Parra ER, Cascone T, Sepesi B, Moghaddam SJ, Scheet P, Negrao MV, Heymach JV, Li M, Dubinett SM, Stevenson CS, Spira AE, Fujimoto J, Solis LM, Wistuba II, Chen J, Wang L, Kadara H
Nature 2024 Mar;627(8004):656-663. Epub 2024 Feb 28 doi: 10.1038/s41586-024-07113-9. PMID: 38418883Free PMC Article
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Chen K, Bai J, Reuben A, Zhao H, Kang G, Zhang C, Qi Q, Xu Y, Hubert S, Chang L, Guan Y, Feng L, Zhang K, Zhang K, Yi X, Xia X, Cheng S, Yang F, Zhang J, Wang J
Am J Respir Crit Care Med 2021 Nov 15;204(10):1180-1192. doi: 10.1164/rccm.202101-0119OC. PMID: 34473939Free PMC Article
Tołoczko-Iwaniuk N, Dziemiańczyk-Pakieła D, Nowaszewska BK, Celińska-Janowicz K, Miltyk W
Curr Drug Targets 2019;20(3):302-315. doi: 10.2174/1389450119666180803121737. PMID: 30073924
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article

Prognosis

Choi JH, Lee BS, Jang JY, Lee YS, Kim HJ, Roh J, Shin YS, Woo HG, Kim CH
Nat Commun 2023 Feb 24;14(1):1055. doi: 10.1038/s41467-023-36691-x. PMID: 36828832Free PMC Article
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, Plotnikov A, Barr H, Tsherniak A, Rozenblatt-Rosen O, Krizhanovsky V, Puram SV, Regev A, Tirosh I
Nat Genet 2020 Nov;52(11):1208-1218. Epub 2020 Oct 30 doi: 10.1038/s41588-020-00726-6. PMID: 33128048Free PMC Article
Tołoczko-Iwaniuk N, Dziemiańczyk-Pakieła D, Nowaszewska BK, Celińska-Janowicz K, Miltyk W
Curr Drug Targets 2019;20(3):302-315. doi: 10.2174/1389450119666180803121737. PMID: 30073924
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article

Clinical prediction guides

Yang N, Huang Y, Yang P, Yan W, Zhang S, Li N, Feng Z
Diagn Pathol 2023 Feb 20;18(1):25. doi: 10.1186/s13000-023-01309-9. PMID: 36803395Free PMC Article
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, Plotnikov A, Barr H, Tsherniak A, Rozenblatt-Rosen O, Krizhanovsky V, Puram SV, Regev A, Tirosh I
Nat Genet 2020 Nov;52(11):1208-1218. Epub 2020 Oct 30 doi: 10.1038/s41588-020-00726-6. PMID: 33128048Free PMC Article
Tołoczko-Iwaniuk N, Dziemiańczyk-Pakieła D, Nowaszewska BK, Celińska-Janowicz K, Miltyk W
Curr Drug Targets 2019;20(3):302-315. doi: 10.2174/1389450119666180803121737. PMID: 30073924

Recent systematic reviews

Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936
Girolami I, Pantanowitz L, Munari E, Martini M, Nocini R, Bisi N, Molteni G, Marchioni D, Ghimenton C, Brunelli M, Eccher A
Head Neck 2020 Oct;42(10):3018-3030. Epub 2020 Jun 22 doi: 10.1002/hed.26339. PMID: 32567746
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Munshi T, Heckman CJ, Darlow S
J Am Dent Assoc 2015 Oct;146(10):760-6. doi: 10.1016/j.adaj.2015.04.014. PMID: 26409986

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