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Immunodeficiency-related disorder

MedGen UID:: 232641
•Concept ID:: C1334159
•: Disease or Syndrome

Synonyms:	Immunodeficiency-Related Disorder; immunodeficiency-related disorder; Immunodepression-Related Disorder; Immunodepression-related disorder; Immunosuppression disorders; Immunosuppression-Related Disorder; Immunosuppression-related disorder

Monarch Initiative:	MONDO:0024572

Definition

A non-neoplastic or neoplastic disorder that develops in a patient with immunodeficiency. Representative examples include AIDS-related disorders and disorders that develop following organ transplantation. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVImmunodeficiency-related disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Immune System and Related Disorders
        Immunodeficiency-related disorder
        AIDS-related disorder
        AIDS-Related Cryptococcosis
        AIDS-Related Enterocolitis
        AIDS-Related Herpes Zoster
        AIDS-Related Human Papillomavirus Infection
        AIDS-Related Isosporiasis
        AIDS-Related Malignant Neoplasm
        AIDS-Related Carcinoma
        AIDS-Related Kaposi Sarcoma
        AIDS-Related Lymphoma
        AIDS-Related Malignant Anal Neoplasm
        AIDS-Related Malignant Cervical Neoplasm
        AIDS-Related Oropharyngeal Candidiasis
        AIDS-Related Pelvic Inflammatory Disease
        AIDS-Related Pneumocystis Pneumonia
        AIDS-Related Retinopathy
        AIDS-Related Toxoplasmosis
        AIDS-Related Vulvovaginal Candidiasis
        HIV-associated nephropathy
        Human immunodeficiency virus encephalopathy
        Dementia associated with AIDS
        Oral hairy leukoplakia
        Hairy Leukoplakia of Tongue
        Immunodeficiency-Related Neoplasm
        Immunodeficiency-Related Malignant Neoplasm
        Immunodeficiency-Related Burkitt Lymphoma
        Methotrexate-Associated Lymphoma
        Transplant-Related Malignant Neoplasm
        Neoplastic Post-Transplant Lymphoproliferative Disorder
        EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder
        Monomorphic Post-Transplant Lymphoproliferative Disorder
        Polymorphic Post-Transplant Lymphoproliferative Disorder
        Transplant-Related Disorder
        Allograft Thrombosis
        Renal Allograft Thrombosis
        Bone Marrow Transplantation Nephropathy
        Chronic Allograft Arteriopathy
        Chronic rejection of renal transplant
        Delayed Graft Function
        Engraftment syndrome
        Graft versus host disease
        Acute graft versus host disease
        Acute on chronic graft-versus-host disease
        Chronic graft versus host disease
        Intestinal Graft Versus Host Disease
        Maternally Derived Graft Versus Host Disease
        Ocular Graft Versus Host Disease
        Steroid Refractory Graft Versus Host Disease
        Hyperacute Allograft Rejection
        Kidney Transplant Rejection
        Acute Cellular Allograft Nephropathy
        Acute Humoral Allograft Nephropathy
        New Onset Diabetes After Transplant
        Post-transplant lymphoproliferative disease
        EBV-Related Post-Transplant Lymphoproliferative Disorder
        Non-Destructive Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center.

Goussault H, Salvator H, Catherinot E, Chabi ML, Tcherakian C, Chabrol A, Didier M, Rivaud E, Fischer A, Suarez F, Hermine O, Lanternier F, Lortholary O, Mahlaoui N, Devillier P, Couderc LJ
Respir Res 2019 Dec 4;20(1):275. doi: 10.1186/s12931-019-1242-4. PMID: 31801528 Free PMC Article

Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma.

Perelygina L, Buchbinder D, Dorsey MJ, Eloit M, Hauck F, Hautala T, Moshous D, Uriarte I, Deripapa E, Icenogle J, Sullivan KE
J Clin Immunol 2019 Jan;39(1):112-117. Epub 2019 Jan 24 doi: 10.1007/s10875-019-0589-0. PMID: 30680653 Free PMC Article

Utilization of genomic sequencing for population screening of immunodeficiencies in the newborn.

Pavey AR, Bodian DL, Vilboux T, Khromykh A, Hauser NS, Huddleston K, Klein E, Black A, Kane MS, Iyer RK, Niederhuber JE, Solomon BD
Genet Med 2017 Dec;19(12):1367-1375. Epub 2017 Jun 15 doi: 10.1038/gim.2017.57. PMID: 28617419

See all (4)

Recent clinical studies

Etiology

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review.

Bintalib HM, van de Ven A, Jacob J, Davidsen JR, Fevang B, Hanitsch LG, Malphettes M, van Montfrans J, Maglione PJ, Milito C, Routes J, Warnatz K, Hurst JR
Front Immunol 2023;14:1190235. Epub 2023 May 8 doi: 10.3389/fimmu.2023.1190235. PMID: 37223103 Free PMC Article

Secondary Immunodeficiency Related to Kidney Disease (SIDKD)-Definition, Unmet Need, and Mechanisms.

Steiger S, Rossaint J, Zarbock A, Anders HJ
J Am Soc Nephrol 2022 Feb;33(2):259-278. Epub 2021 Dec 14 doi: 10.1681/ASN.2021091257. PMID: 34907031 Free PMC Article

HIV-associated Burkitt lymphoma.

Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838

Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.

Bhavsar T, Crane GM
Curr Hematol Malig Rep 2020 Aug;15(4):360-371. doi: 10.1007/s11899-020-00594-1. PMID: 32535851

Lymphoid proliferations associated with human immunodeficiency virus infection.

Chadburn A, Abdul-Nabi AM, Teruya BS, Lo AA
Arch Pathol Lab Med 2013 Mar;137(3):360-70. doi: 10.5858/arpa.2012-0095-RA. PMID: 23451747

See all (47)

Diagnosis

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review.

Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.

Bhavsar T, Crane GM
Curr Hematol Malig Rep 2020 Aug;15(4):360-371. doi: 10.1007/s11899-020-00594-1. PMID: 32535851

EBV-Associated Lymphoproliferative Disorders: Update in Classification.

Rezk SA, Weiss LM
Surg Pathol Clin 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002. PMID: 31352986

Pulmonary Hypertension in HIV.

Basyal B, Jarrett H, Barnett CF
Can J Cardiol 2019 Mar;35(3):288-298. doi: 10.1016/j.cjca.2019.01.005. PMID: 30825951

Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders.

Agarwal S, Cunningham-Rundles C
Immunol Allergy Clin North Am 2019 Feb;39(1):81-94. doi: 10.1016/j.iac.2018.08.006. PMID: 30466774 Free PMC Article

See all (45)

Therapy

Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.

Bhavsar T, Crane GM
Curr Hematol Malig Rep 2020 Aug;15(4):360-371. doi: 10.1007/s11899-020-00594-1. PMID: 32535851

Efficacy and Tolerability of Intravenous Immunoglobulin and Subcutaneous Immunoglobulin in Neurologic Diseases.

Chen Y, Wang C, Xu F, Ming F, Zhang H
Clin Ther 2019 Oct;41(10):2112-2136. Epub 2019 Aug 21 doi: 10.1016/j.clinthera.2019.07.009. PMID: 31445679

EBV-Associated Lymphoproliferative Disorders: Update in Classification.

Rezk SA, Weiss LM
Surg Pathol Clin 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002. PMID: 31352986

Immunodeficiency-related vaccine-derived poliovirus (iVDPV) cases: a systematic review and implications for polio eradication.

Guo J, Bolivar-Wagers S, Srinivas N, Holubar M, Maldonado Y
Vaccine 2015 Mar 3;33(10):1235-42. Epub 2015 Jan 16 doi: 10.1016/j.vaccine.2015.01.018. PMID: 25600519 Free PMC Article

Immunodeficiency-related Hodgkin lymphoma and its mimics.

Said JW
Adv Anat Pathol 2007 May;14(3):189-94. doi: 10.1097/PAP.0b013e31805048fc. PMID: 17452815

See all (29)

Prognosis

Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia.

Somasundaram N, Meyer O, Scheibenbogen C, Hanitsch LG, Stittrich A, Kölsch U, Wittke K
Clin Exp Med 2023 Dec;23(8):5423-5432. Epub 2023 Sep 5 doi: 10.1007/s10238-023-01166-2. PMID: 37670184 Free PMC Article

HIV-associated Burkitt lymphoma.

Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838

Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.

Bhavsar T, Crane GM
Curr Hematol Malig Rep 2020 Aug;15(4):360-371. doi: 10.1007/s11899-020-00594-1. PMID: 32535851

EBV-Associated Lymphoproliferative Disorders: Update in Classification.

Rezk SA, Weiss LM
Surg Pathol Clin 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002. PMID: 31352986

Pulmonary Hypertension in HIV.

Basyal B, Jarrett H, Barnett CF
Can J Cardiol 2019 Mar;35(3):288-298. doi: 10.1016/j.cjca.2019.01.005. PMID: 30825951

See all (28)

Clinical prediction guides

Integrating Clinics, Laboratory, and Imaging for the Diagnosis of Common Variable Immunodeficiency-Related Granulomatous-Lymphocytic Interstitial Lung Disease.

Cabanero-Navalon MD, Garcia-Bustos V, Forero-Naranjo LF, Baettig-Arriagada EJ, Núñez-Beltrán M, Cañada-Martínez AJ, Forner Giner MJ, Catalán-Cáceres N, Martínez Francés M, Moral Moral P
Front Immunol 2022;13:813491. Epub 2022 Feb 23 doi: 10.3389/fimmu.2022.813491. PMID: 35281075 Free PMC Article

Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center.

Utilization of genomic sequencing for population screening of immunodeficiencies in the newborn.

Clinical Predictors of a Diagnosis of Common Variable Immunodeficiency-related Granulomatous-Lymphocytic Interstitial Lung Disease.

Mannina A, Chung JH, Swigris JJ, Solomon JJ, Huie TJ, Yunt ZX, Truong TQ, Brown KK, Achcar RD, Olson AL, Cox CW, Kligerman SJ, Curran-Everett D, Fernández Pérez ER
Ann Am Thorac Soc 2016 Jul;13(7):1042-9. doi: 10.1513/AnnalsATS.201511-728OC. PMID: 27064856

Therapeutic application of calf thymus extract (TFX).

Skotnicki AB
Med Oncol Tumor Pharmacother 1989;6(1):31-43. doi: 10.1007/BF02985221. PMID: 2657248

See all (25)

Recent systematic reviews

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review.

Burkitt and Burkitt-Like Lymphomas: a Systematic Review.

Saleh K, Michot JM, Camara-Clayette V, Vassetsky Y, Ribrag V
Curr Oncol Rep 2020 Mar 6;22(4):33. doi: 10.1007/s11912-020-0898-8. PMID: 32144513

Immunodeficiency-related vaccine-derived poliovirus (iVDPV) cases: a systematic review and implications for polio eradication.

Guo J, Bolivar-Wagers S, Srinivas N, Holubar M, Maldonado Y
Vaccine 2015 Mar 3;33(10):1235-42. Epub 2015 Jan 16 doi: 10.1016/j.vaccine.2015.01.018. PMID: 25600519 Free PMC Article

See all (3)

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Immunodeficiency-related disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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