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Intermediate Lipomatous Neoplasm

MedGen UID:
232652
•Concept ID:
C1334217
•
Neoplastic Process

Definition

A lipomatous neoplasm characterized by a high risk of local recurrence and no risk of metastasis. [from NCI]

Professional guidelines

PubMed

Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment.
Saifuddin A, Andrei V, Rajakulasingam R, Oliveira I, Seddon B
Skeletal Radiol 2021 Oct;50(10):1963-1980. Epub 2021 Apr 1 doi: 10.1007/s00256-021-03769-w. PMID: 33792747
Value of intravoxel incoherent motion for differential diagnosis of renal tumors.
Zhu Q, Zhu W, Ye J, Wu J, Chen W, Hao Z
Acta Radiol 2019 Mar;60(3):382-387. Epub 2018 Jun 4 doi: 10.1177/0284185118778884. PMID: 29863413
Histologic Appearance After Preoperative Radiation Therapy for Soft Tissue Sarcoma: Assessment of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group Response Score.
Schaefer IM, Hornick JL, Barysauskas CM, Raut CP, Patel SA, Royce TJ, Fletcher CDM, Baldini EH
Int J Radiat Oncol Biol Phys 2017 Jun 1;98(2):375-383. Epub 2017 Feb 24 doi: 10.1016/j.ijrobp.2017.02.087. PMID: 28463157

Recent clinical studies

Etiology

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
Rossmeislová L, Gojda J, Smolková K
Cancer Metastasis Rev 2021 Dec;40(4):1115-1139. Epub 2021 Dec 28 doi: 10.1007/s10555-021-10016-0. PMID: 34962613
Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
Chamberlain FE, Wilding C, Jones RL, Huang P
Expert Opin Investig Drugs 2019 Jun;28(6):505-511. Epub 2019 Apr 22 doi: 10.1080/13543784.2019.1607291. PMID: 31010343
Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial.
Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D'Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR
Lancet 2016 Apr 16;387(10028):1629-37. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01283-0. PMID: 26874885
Pathology and genetics of adipocytic tumors.
Hameed M
Cytogenet Genome Res 2007;118(2-4):138-47. doi: 10.1159/000108294. PMID: 18000364

Diagnosis

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Management of adipose tumors in the limbs.
Le Nail LR, Crenn V, Rosset P, Ropars M
Orthop Traumatol Surg Res 2022 Feb;108(1S):103162. Epub 2021 Dec 1 doi: 10.1016/j.otsr.2021.103162. PMID: 34863958
Diagnosis strategy of adipocytic soft-tissue tumors in adults: a consensus from European experts.
Moulin B, Messiou C, Crombe A, Kind M, Hohenberger P, Rutkowski P, van Houdt WJ, Strauss D, Gronchi A, Bonvalot S
Eur J Surg Oncol 2022 Mar;48(3):518-525. Epub 2021 Oct 18 doi: 10.1016/j.ejso.2021.10.009. PMID: 34688512
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Pathology and genetics of adipocytic tumors.
Hameed M
Cytogenet Genome Res 2007;118(2-4):138-47. doi: 10.1159/000108294. PMID: 18000364

Therapy

Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
Chamberlain FE, Wilding C, Jones RL, Huang P
Expert Opin Investig Drugs 2019 Jun;28(6):505-511. Epub 2019 Apr 22 doi: 10.1080/13543784.2019.1607291. PMID: 31010343
Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial.
Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D'Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR
Lancet 2016 Apr 16;387(10028):1629-37. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01283-0. PMID: 26874885
Sustained complete remission of a limited-stage blastic plasmacytoid dendritic cell neoplasm followed by a simultaneous combination of low-dose DeVIC therapy and radiation therapy: a case report and review of the literature.
Sugimoto KJ, Shimada A, Yamaguchi N, Imai H, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M
Int J Clin Exp Pathol 2013;6(11):2603-8. Epub 2013 Oct 15 PMID: 24228127Free PMC Article
Update on the use of aromatase inhibitors in breast cancer.
Brueggemeier RW
Expert Opin Pharmacother 2006 Oct;7(14):1919-30. doi: 10.1517/14656566.7.14.1919. PMID: 17020418
Issues in the design and interpretation of studies of fatty acids and cancer in humans.
Byers T, Gieseker K
Am J Clin Nutr 1997 Dec;66(6 Suppl):1541S-1547S. doi: 10.1093/ajcn/66.6.1541S. PMID: 9394713

Prognosis

Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
Rossmeislová L, Gojda J, Smolková K
Cancer Metastasis Rev 2021 Dec;40(4):1115-1139. Epub 2021 Dec 28 doi: 10.1007/s10555-021-10016-0. PMID: 34962613
The incidence and relevance of non-fatty components in trunk and extremity lipomatous soft tissue masses.
Berkeley R, Okereke O, Malhotra K, Saifuddin A
Br J Radiol 2021 Jun 1;94(1122):20201403. Epub 2021 May 20 doi: 10.1259/bjr.20201403. PMID: 33882249Free PMC Article
Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment.
Saifuddin A, Andrei V, Rajakulasingam R, Oliveira I, Seddon B
Skeletal Radiol 2021 Oct;50(10):1963-1980. Epub 2021 Apr 1 doi: 10.1007/s00256-021-03769-w. PMID: 33792747
Diagnostic performance of MRI and histology in assessment of deep lipomatous tumours.
Cairncross L, Snow HA, Strauss DC, Smith MJF, Sjokvist O, Messiou C, Thway K, Hayes AJ
Br J Surg 2019 Dec;106(13):1794-1799. Epub 2019 Sep 10 doi: 10.1002/bjs.11309. PMID: 31502664
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243

Clinical prediction guides

What Are the Results of Resection of Localized Dedifferentiated Liposarcomas in the Extremities?
Nakata E, Kunisada T, Hasei J, Nakahara R, Yanai H, Toji T, Inoue Ct H, Ozaki T
Clin Orthop Relat Res 2020 Nov;478(11):2550-2561. doi: 10.1097/CORR.0000000000001338. PMID: 33112583Free PMC Article
Brown Adipose Tissue in Breast Cancer Evaluated by [(18)F] FDG-PET/CT.
Pace L, Nicolai E, Basso L, Garbino N, Soricelli A, Salvatore M
Mol Imaging Biol 2020 Aug;22(4):1111-1115. doi: 10.1007/s11307-020-01482-z. PMID: 32034622
Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments.
Sassa N, Yokoyama Y, Nishida Y, Yamada S, Uchida H, Kajiyama H, Nagino M, Kodera Y, Gotoh M
Int J Clin Oncol 2020 May;25(5):929-936. Epub 2020 Jan 16 doi: 10.1007/s10147-020-01620-1. PMID: 31950376
Diagnostic performance of MRI and histology in assessment of deep lipomatous tumours.
Cairncross L, Snow HA, Strauss DC, Smith MJF, Sjokvist O, Messiou C, Thway K, Hayes AJ
Br J Surg 2019 Dec;106(13):1794-1799. Epub 2019 Sep 10 doi: 10.1002/bjs.11309. PMID: 31502664
Active surveillance for clinically localized renal tumors: An updated review of current indications and clinical outcomes.
Borghesi M, Brunocilla E, Volpe A, Dababneh H, Pultrone CV, Vagnoni V, La Manna G, Porreca A, Martorana G, Schiavina R
Int J Urol 2015 May;22(5):432-8. Epub 2015 Mar 17 doi: 10.1111/iju.12734. PMID: 25781204

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