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Tenosynovial giant cell tumor

MedGen UID:
232927
Concept ID:
C1318543
Neoplastic Process
Synonyms: Fibrous Histiocytoma of Tendon Sheath; Giant Cell Tumor of Tendon Sheath; Tenosynovial Giant Cell Tumor
SNOMED CT: Giant cell tumor of tendon sheath (95413004); Giant cell tumor of tendon sheath (128777004); Fibrous histiocytoma of tendon sheath (128777004); Tenosynovial giant cell tumor (128777004); Fibrous histiocytoma of tendon sheath (310605004)
 
Monarch Initiative: MONDO:0002522

Definition

A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse. [from NCI]

Professional guidelines

PubMed

Chan AS, Katiyar V, Dy P, Singh V
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. PMID: 37363972
Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703

Recent clinical studies

Etiology

Barnett JR, Rudran B, Khan A, O'Reilly-Harbidge S, Patel S, Malhotra K, Cullen N, Welck M, Aston W
Foot Ankle Int 2023 Oct;44(10):1013-1020. Epub 2023 Aug 30 doi: 10.1177/10711007231189491. PMID: 37644900
Palmerini E, Healey JH, Bernthal NM, Bauer S, Schreuder H, Leithner A, Martin-Broto J, Gouin F, Lopez-Bastida J, Gelderblom H, Staals EL, Mercier F, Laeis P, Ye X, van de Sande M
Oncologist 2023 Jun 2;28(6):e425-e435. doi: 10.1093/oncolo/oyad011. PMID: 36869793Free PMC Article
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Zenginkinet T, Faruq AU, Toksoz Yildirim AN, Iyetin Y, Ozturan B, Okay E, Celik A, Ozkan K, Akyurek M
Medicina (Kaunas) 2022 Sep 13;58(9) doi: 10.3390/medicina58091270. PMID: 36143947Free PMC Article
Alsayadi YMMA, Chawla PA
Anticancer Agents Med Chem 2021;21(12):1510-1519. doi: 10.2174/1871520620999201102123555. PMID: 33143617

Diagnosis

Kao EY, Chen EY
Surg Pathol Clin 2024 Mar;17(1):77-82. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.006. PMID: 38278609
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Zenginkinet T, Faruq AU, Toksoz Yildirim AN, Iyetin Y, Ozturan B, Okay E, Celik A, Ozkan K, Akyurek M
Medicina (Kaunas) 2022 Sep 13;58(9) doi: 10.3390/medicina58091270. PMID: 36143947Free PMC Article
Anaya JEC, Coelho SRN, Taneja AK, Cardoso FN, Skaf AY, Aihara AY
Radiographics 2021 Mar-Apr;41(2):543-558. Epub 2021 Jan 22 doi: 10.1148/rg.2021200079. PMID: 33481690
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604

Therapy

Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703
Lamb YN
Drugs 2019 Nov;79(16):1805-1812. doi: 10.1007/s40265-019-01210-0. PMID: 31602563Free PMC Article
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604

Prognosis

Chan AS, Katiyar V, Dy P, Singh V
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. PMID: 37363972
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH
Mol Cancer Ther 2021 Aug;20(8):1388-1399. Epub 2021 Jun 4 doi: 10.1158/1535-7163.MCT-20-0591. PMID: 34088832Free PMC Article
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689
Ravi V, Wang WL, Lewis VO
Curr Opin Oncol 2011 Jul;23(4):361-6. doi: 10.1097/CCO.0b013e328347e1e3. PMID: 21577109

Clinical prediction guides

Palmerini E, Healey JH, Bernthal NM, Bauer S, Schreuder H, Leithner A, Martin-Broto J, Gouin F, Lopez-Bastida J, Gelderblom H, Staals EL, Mercier F, Laeis P, Ye X, van de Sande M
Oncologist 2023 Jun 2;28(6):e425-e435. doi: 10.1093/oncolo/oyad011. PMID: 36869793Free PMC Article
Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689
Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303Free PMC Article

Recent systematic reviews

Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Siegel M, Bode L, Südkamp N, Kühle J, Zwingmann J, Schmal H, Herget GW
PLoS One 2021;16(12):e0260795. Epub 2021 Dec 2 doi: 10.1371/journal.pone.0260795. PMID: 34855875Free PMC Article
Zeoli T, Mathkour M, Scullen T, Carr C, Abou-Al-Shaar H, Wang L, Divagaran A, Dindial R, Tubbs RS, Bui CJ, Maulucci CM
Clin Neurol Neurosurg 2021 Mar;202:106489. Epub 2021 Jan 12 doi: 10.1016/j.clineuro.2021.106489. PMID: 33596487
Healey JH, Bernthal NM, van de Sande M
J Am Acad Orthop Surg Glob Res Rev 2020 Nov;4(11):e20.00028. doi: 10.5435/JAAOSGlobal-D-20-00028. PMID: 33156160Free PMC Article
Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R
Drug Des Devel Ther 2020;14:1693-1704. Epub 2020 May 4 doi: 10.2147/DDDT.S253232. PMID: 32440095Free PMC Article

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