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Tenosynovial giant cell tumor

MedGen UID:
232927
•Concept ID:
C1318543
•
Neoplastic Process
Synonyms: Fibrous Histiocytoma of Tendon Sheath; Giant Cell Tumor of Tendon Sheath; Tenosynovial Giant Cell Tumor
SNOMED CT: Giant cell tumor of tendon sheath (95413004); Giant cell tumor of tendon sheath (128777004); Fibrous histiocytoma of tendon sheath (128777004); Tenosynovial giant cell tumor (128777004); Fibrous histiocytoma of tendon sheath (310605004)
 
Monarch Initiative: MONDO:0002522

Definition

A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse. [from NCI]

Professional guidelines

PubMed

Treatment updates on tenosynovial giant cell tumor.
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703
Differential Diagnosis of Facet Joint Disorders.
Anaya JEC, Coelho SRN, Taneja AK, Cardoso FN, Skaf AY, Aihara AY
Radiographics 2021 Mar-Apr;41(2):543-558. Epub 2021 Jan 22 doi: 10.1148/rg.2021200079. PMID: 33481690
Management of Pigmented Villonodular Synovitis (PVNS): an Orthopedic Surgeon's Perspective.
Bernthal NM, Ishmael CR, Burke ZDC
Curr Oncol Rep 2020 Jun 4;22(6):63. doi: 10.1007/s11912-020-00926-7. PMID: 32494892

Recent clinical studies

Etiology

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Turalio risk evaluation and mitigation strategy for treatment of tenosynovial giant cell tumor: framework and experience.
Dharmani C, Wang E, Salas M, McCabe C, Diggs A, Choi Y, Jiang J, Keedy VL
Future Oncol 2022 Apr;18(13):1595-1607. Epub 2022 Feb 2 doi: 10.2217/fon-2021-1475. PMID: 35105158
Prospects of Treating Tenosynovial Giant Cell Tumor through Pexidartinib: A Review.
Alsayadi YMMA, Chawla PA
Anticancer Agents Med Chem 2021;21(12):1510-1519. doi: 10.2174/1871520620999201102123555. PMID: 33143617
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region.
Lee JC, Huang HY
Head Neck Pathol 2020 Mar;14(1):97-108. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01086-2. PMID: 31950466Free PMC Article
Tenosynovial giant cell tumor in the foot and ankle.
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689

Diagnosis

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Differential Diagnosis of Facet Joint Disorders.
Anaya JEC, Coelho SRN, Taneja AK, Cardoso FN, Skaf AY, Aihara AY
Radiographics 2021 Mar-Apr;41(2):543-558. Epub 2021 Jan 22 doi: 10.1148/rg.2021200079. PMID: 33481690
Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.
Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187
Pigmented villonodular synovitis.
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis).
Gouin F, Noailles T
Orthop Traumatol Surg Res 2017 Feb;103(1S):S91-S97. Epub 2017 Jan 2 doi: 10.1016/j.otsr.2016.11.002. PMID: 28057477

Therapy

CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.
Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Treatment updates on tenosynovial giant cell tumor.
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703
Pexidartinib: First Approval.
Lamb YN
Drugs 2019 Nov;79(16):1805-1812. doi: 10.1007/s40265-019-01210-0. PMID: 31602563Free PMC Article
Pigmented villonodular synovitis.
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604

Prognosis

Updates on the Treatment of Tenosynovial Giant Cell Tumor.
Chan AS, Katiyar V, Dy P, Singh V
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. PMID: 37363972
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment.
Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH
Mol Cancer Ther 2021 Aug;20(8):1388-1399. Epub 2021 Jun 4 doi: 10.1158/1535-7163.MCT-20-0591. PMID: 34088832Free PMC Article
Tenosynovial giant cell tumor in the foot and ankle.
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis.
Ravi V, Wang WL, Lewis VO
Curr Opin Oncol 2011 Jul;23(4):361-6. doi: 10.1097/CCO.0b013e328347e1e3. PMID: 21577109

Clinical prediction guides

Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.
Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Pexidartinib: first approved systemic therapy for patients with tenosynovial giant cell tumor.
Gelderblom H, de Sande MV
Future Oncol 2020 Oct;16(29):2345-2356. Epub 2020 Jul 23 doi: 10.2217/fon-2020-0542. PMID: 32700568
Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.
Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187
Tenosynovial giant cell tumor in the foot and ankle.
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis.
Brahmi M, Vinceneux A, Cassier PA
Curr Treat Options Oncol 2016 Feb;17(2):10. doi: 10.1007/s11864-015-0385-x. PMID: 26820289

Recent systematic reviews

Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.
Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Management of Tenosynovial Giant Cell Tumor: A Neoplastic and Inflammatory Disease.
Healey JH, Bernthal NM, van de Sande M
J Am Acad Orthop Surg Glob Res Rev 2020 Nov;4(11):e20.00028. doi: 10.5435/JAAOSGlobal-D-20-00028. PMID: 33156160Free PMC Article
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development.
Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R
Drug Des Devel Ther 2020;14:1693-1704. Epub 2020 May 4 doi: 10.2147/DDDT.S253232. PMID: 32440095Free PMC Article
Tenosynovial Giant Cell Tumors in Children: A Similar Entity Compared With Adults.
Mastboom MJL, Verspoor FGM, Uittenbogaard D, Schaap GR, Jutte PC, Schreuder HWB, van de Sande MAJ
Clin Orthop Relat Res 2018 Sep;476(9):1803-1812. doi: 10.1007/s11999.0000000000000102. PMID: 29494352Free PMC Article
Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature.
Wang K, Zhu B, Yang S, Liu Z, Yu M, Liu X
Turk Neurosurg 2014;24(5):804-13. doi: 10.5137/1019-5149.JTN.9594-13.1. PMID: 25269059

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