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T-cell/histiocyte rich large B cell lymphoma

MedGen UID:
232943
Concept ID:
C1321547
Neoplastic Process
Synonyms: Histiocyte-rich large B-cell lymphoma; T-cell histiocyte rich large B-cell lymphoma; T-cell hystiocyte rich large B-cell lymphoma; T-cell rich large B-cell lymphoma; T-cell rich/histiocyte-rich large B-cell lymphoma; T-Cell Rich/Histiocyte-Rich Large B-Cell Lymphoma; T-cell/histiocyte rich large B-cell lymphoma; T-Cell/Histiocyte Rich Lymphoma; T-cell/histiocyte rich lymphoma; T-Cell/Histiocyte-Rich Large B-Cell Lymphoma; T-cell/histiocyte-rich large B-cell lymphoma; THRLBCL
SNOMED CT: T-cell/histiocyte rich large B-cell lymphoma (450959001); T-cell rich large B-cell lymphoma (450959001); T-cell rich/histiocyte-rich large B-cell lymphoma (450959001); Histiocyte-rich large B-cell lymphoma (450959001); T-cell hystiocyte rich large B-cell lymphoma (724645006); T-cell histiocyte rich large B-cell lymphoma (724645006)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017597
Orphanet: ORPHA300857

Definition

T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare variant of diffuse large B-cell lymphoma (DLBCL; see this term), mainly affecting middle-aged men and often not being discovered until an advanced disease stage, with involvement of the spleen, liver and bone marrow occurring at a greater frequency than in DLBCL. It is often difficult to diagnose due to its similarity with other lymphoid diseases such as classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma (see these terms) and has an aggressive clinical course. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell/histiocyte rich large B cell lymphoma
Follow this link to review classifications for T-cell/histiocyte rich large B cell lymphoma in Orphanet.

Professional guidelines

PubMed

Dogan A, Burke JS, Goteri G, Stitson RN, Wotherspoon AC, Isaacson PG
Am J Surg Pathol 2003 Jul;27(7):903-11. doi: 10.1097/00000478-200307000-00005. PMID: 12826882
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Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341

Recent clinical studies

Etiology

Ally F, Gajzer D, Fromm JR
Clin Lab Med 2023 Sep;43(3):427-444. Epub 2023 Jun 23 doi: 10.1016/j.cll.2023.04.011. PMID: 37481321
Kosari F, Bakhshi T, Ameli F, Mokhtari M
BMC Cancer 2022 Dec 28;22(1):1359. doi: 10.1186/s12885-022-10321-z. PMID: 36577979Free PMC Article
Gorodetskiy VR, Probatova NA, Vasilyev VI
Int J Rheum Dis 2020 Apr;23(4):540-548. Epub 2020 Feb 25 doi: 10.1111/1756-185X.13800. PMID: 32100426Free PMC Article
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
Ollila TA, Reagan JL, Olszewski AJ
Leuk Lymphoma 2019 Dec;60(14):3426-3433. Epub 2019 Jul 9 doi: 10.1080/10428194.2019.1639166. PMID: 31287335Free PMC Article

Diagnosis

Samueli B, Nalbandyan K, Benharroch D, Levi I
Acta Haematol 2022;145(3):310-317. Epub 2021 Nov 9 doi: 10.1159/000520791. PMID: 34753138Free PMC Article
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Zheng SM, Zhou DJ, Chen YH, Jiang R, Wang YX, Zhang Y, Xue HL, Wang HQ, Mou D, Zeng WZ
World J Gastroenterol 2017 Jun 28;23(24):4467-4472. doi: 10.3748/wjg.v23.i24.4467. PMID: 28706431Free PMC Article
Tousseyn T, De Wolf-Peeters C
Virchows Arch 2011 Dec;459(6):557-63. Epub 2011 Nov 12 doi: 10.1007/s00428-011-1165-z. PMID: 22081105

Therapy

Toro J, Patiño J, Flórez A, Rivera JS
BMJ Case Rep 2022 Feb 8;15(2) doi: 10.1136/bcr-2021-246355. PMID: 35135790Free PMC Article
Samueli B, Nalbandyan K, Benharroch D, Levi I
Acta Haematol 2022;145(3):310-317. Epub 2021 Nov 9 doi: 10.1159/000520791. PMID: 34753138Free PMC Article
Ollila TA, Reagan JL, Olszewski AJ
Leuk Lymphoma 2019 Dec;60(14):3426-3433. Epub 2019 Jul 9 doi: 10.1080/10428194.2019.1639166. PMID: 31287335Free PMC Article
Zheng SM, Zhou DJ, Chen YH, Jiang R, Wang YX, Zhang Y, Xue HL, Wang HQ, Mou D, Zeng WZ
World J Gastroenterol 2017 Jun 28;23(24):4467-4472. doi: 10.3748/wjg.v23.i24.4467. PMID: 28706431Free PMC Article
Hartmann S, Döring C, Jakobus C, Rengstl B, Newrzela S, Tousseyn T, Sagaert X, Ponzoni M, Facchetti F, de Wolf-Peeters C, Steidl C, Gascoyne R, Küppers R, Hansmann ML
PLoS One 2013;8(11):e78812. Epub 2013 Nov 11 doi: 10.1371/journal.pone.0078812. PMID: 24244368Free PMC Article

Prognosis

Schmitz C, Rekowski J, Reinke S, Müller SP, Hüttmann A, Klapper W, Dührsen U
Leuk Lymphoma 2020 Jun;61(6):1372-1379. Epub 2020 Feb 5 doi: 10.1080/10428194.2020.1713319. PMID: 32022621
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Zheng SM, Zhou DJ, Chen YH, Jiang R, Wang YX, Zhang Y, Xue HL, Wang HQ, Mou D, Zeng WZ
World J Gastroenterol 2017 Jun 28;23(24):4467-4472. doi: 10.3748/wjg.v23.i24.4467. PMID: 28706431Free PMC Article
Hartmann S
Pathol Res Pract 2015 Dec;211(12):901-4. Epub 2015 Oct 28 doi: 10.1016/j.prp.2015.10.012. PMID: 26596262

Clinical prediction guides

Hartmann S, Dojcinov S, Dotlic S, Gibson SE, Hsi ED, Klapper W, Klimkowska M, Pinilla SMR, Richter J, Sabattini E, Tousseyn T, de Jong D
Virchows Arch 2023 Oct;483(4):451-463. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03554-1. PMID: 37530790Free PMC Article
Griffin GK, Weirather JL, Roemer MGM, Lipschitz M, Kelley A, Chen PH, Gusenleitner D, Jeter E, Pak C, Gjini E, Chapuy B, Rosenthal MH, Xu J, Chen BJ, Sohani AR, Lovitch SB, Abramson JS, Ishizuka JJ, Kim AI, Jacobson CA, LaCasce AS, Fletcher CD, Neuberg D, Freeman GJ, Hodi FS, Wright K, Ligon AH, Jacobsen ED, Armand P, Shipp MA, Rodig SJ
Blood 2021 Mar 11;137(10):1353-1364. doi: 10.1182/blood.2020006464. PMID: 32871584Free PMC Article
Barut F, Kandemir NO, Gun BD, Ozdamar SO
J Pak Med Assoc 2016 Jul;66(7):905-7. PMID: 27427148
Vezzoli P, Fiorani R, Girgenti V, Fanoni D, Tavecchio S, Balice Y, Mozzana R, Crosti C, Berti E
Dermatology 2011;222(3):225-30. Epub 2011 Apr 30 doi: 10.1159/000327376. PMID: 21540569
Mourad WA, Al Thani S, Tbakhi A, Al Omari M, Khafaga Y, Shoukri M, El Weshi A, Al Shabana M, Ezzat A
Hematol Oncol Stem Cell Ther 2008 Jan-Mar;1(1):22-7. doi: 10.1016/s1658-3876(08)50056-2. PMID: 20063524

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