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Major Salivary Gland Sarcoma

MedGen UID:
233141
•Concept ID:
C1334553
•
Neoplastic Process
Synonyms: Sarcoma of Major Salivary Gland; Sarcoma of the Major Salivary Gland

Definition

A rare malignant soft tissue neoplasm that arises from the parotid gland, submandibular gland, or sublingual gland. Representative examples include fibrosarcoma, angiosarcoma, leiomyosarcoma, and Kaposi sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMajor Salivary Gland Sarcoma

Professional guidelines

PubMed

Radiation-Related New Primary Solid Cancers in the Childhood Cancer Survivor Study: Comparative Radiation Dose Response and Modification of Treatment Effects.
Inskip PD, Sigurdson AJ, Veiga L, Bhatti P, Ronckers C, Rajaraman P, Boukheris H, Stovall M, Smith S, Hammond S, Henderson TO, Watt TC, Mertens AC, Leisenring W, Stratton K, Whitton J, Donaldson SS, Armstrong GT, Robison LL, Neglia JP
Int J Radiat Oncol Biol Phys 2016 Mar 15;94(4):800-7. Epub 2015 Dec 15 doi: 10.1016/j.ijrobp.2015.11.046. PMID: 26972653Free PMC Article

Recent clinical studies

Etiology

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Oral Cavity Cancer in the Indian Subcontinent - Challenges and Opportunities.
Mummudi N, Agarwal JP, Chatterjee S, Mallick I, Ghosh-Laskar S
Clin Oncol (R Coll Radiol) 2019 Aug;31(8):520-528. Epub 2019 Jun 4 doi: 10.1016/j.clon.2019.05.013. PMID: 31174947
Is open surgery for head and neck cancers truly declining?
Hartl DM, Brasnu DF, Shah JP, Hinni ML, Takes RP, Olsen KD, Kowalski LP, Rodrigo JP, Strojan P, Wolf GT, Rinaldo A, Suárez C, Mendenhall WM, Paleri V, Forastiere AA, Werner JA, Ferlito A
Eur Arch Otorhinolaryngol 2013 Nov;270(11):2793-802. Epub 2013 Jan 3 doi: 10.1007/s00405-012-2322-y. PMID: 23283241
Human herpesvirus 6: An emerging pathogen.
Campadelli-Fiume G, Mirandola P, Menotti L
Emerg Infect Dis 1999 May-Jun;5(3):353-66. doi: 10.3201/eid0503.990306. PMID: 10341172Free PMC Article
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Diagnosis

Buccal space tumours.
Hasan Z, Tan D, Buchanan M, Palme C, Riffat F
Auris Nasus Larynx 2019 Apr;46(2):160-166. Epub 2018 Jul 18 doi: 10.1016/j.anl.2018.06.011. PMID: 30031665
Examination of the patient with head and neck cancer.
Georgopoulos R, Liu JC
Surg Oncol Clin N Am 2015 Jul;24(3):409-21. Epub 2015 Apr 9 doi: 10.1016/j.soc.2015.03.003. PMID: 25979391
Oral lesions associated with human immunodeficiency virus disease.
Patton LL
Dent Clin North Am 2013 Oct;57(4):673-98. Epub 2013 Aug 15 doi: 10.1016/j.cden.2013.07.005. PMID: 24034072
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839
Primary sarcomas of the major salivary glands.
Luna MA, Tortoledo ME, Ordóñez NG, Frankenthaler RA, Batsakis JG
Arch Otolaryngol Head Neck Surg 1991 Mar;117(3):302-6. doi: 10.1001/archotol.1991.01870150070009. PMID: 1998570

Therapy

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations.
Kaplan I, Raiser V, Shuster A, Shlomi B, Rosenfeld E, Greenberg A, Hirshberg A, Yahalom R, Shnaiderman-Shapiro A, Vered M
Acta Histochem 2019 Nov;121(8):151448. Epub 2019 Sep 27 doi: 10.1016/j.acthis.2019.151448. PMID: 31570205
Oral lesions associated with human immunodeficiency virus disease.
Patton LL
Dent Clin North Am 2013 Oct;57(4):673-98. Epub 2013 Aug 15 doi: 10.1016/j.cden.2013.07.005. PMID: 24034072
Long-term survival of a phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases.
Den Hengst WA, Van Putte BP, Hendriks JM, Stockman B, van Boven WJ, Weyler J, Schramel FM, Van Schil PE
Eur J Cardiothorac Surg 2010 Nov;38(5):621-7. Epub 2010 May 15 doi: 10.1016/j.ejcts.2010.03.048. PMID: 20478715
The use of neutrons in cancer therapy: a historical perspective through the modern era.
Laramore GE
Semin Oncol 1997 Dec;24(6):672-85. PMID: 9422263

Prognosis

Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy.
Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ
Laryngoscope 2020 May;130(5):E335-E339. Epub 2019 Jul 10 doi: 10.1002/lary.28183. PMID: 31291005
Oral Cavity Cancer in the Indian Subcontinent - Challenges and Opportunities.
Mummudi N, Agarwal JP, Chatterjee S, Mallick I, Ghosh-Laskar S
Clin Oncol (R Coll Radiol) 2019 Aug;31(8):520-528. Epub 2019 Jun 4 doi: 10.1016/j.clon.2019.05.013. PMID: 31174947
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147
Primary sarcomas of the major salivary glands.
Luna MA, Tortoledo ME, Ordóñez NG, Frankenthaler RA, Batsakis JG
Arch Otolaryngol Head Neck Surg 1991 Mar;117(3):302-6. doi: 10.1001/archotol.1991.01870150070009. PMID: 1998570

Clinical prediction guides

The number and ratio of positive lymph nodes are independent prognostic factors for patients with major salivary gland cancer: Results from the surveillance, epidemiology, and End Results dataset.
Qian K, Sun W, Guo K, Zheng X, Sun T, Chen L, Xiang J, Li D, Wu Y, Ji Q, Wang Z
Eur J Surg Oncol 2019 Jun;45(6):1025-1032. Epub 2018 Nov 15 doi: 10.1016/j.ejso.2018.11.008. PMID: 30472214
Diagnostic reliability of pretreatment biopsy in malignant nasoethmoidal tumors: A retrospective study of 77 cases.
Schreiber A, Rampinelli V, Ferrari M, Mattavelli D, Farina D, Battocchio S, Nicolai P
Laryngoscope 2018 Aug;128(8):1772-1777. Epub 2018 Jan 4 doi: 10.1002/lary.27077. PMID: 29314070
FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi-institutional study of 184 cases.
Wang H, Hoda RS, Faquin W, Rossi ED, Hotchandani N, Sun T, Pusztaszeri M, Bizzarro T, Bongiovanni M, Patel V, Jhala N, Fadda G, Gong Y
Cancer Cytopathol 2017 Feb;125(2):91-103. Epub 2016 Dec 21 doi: 10.1002/cncy.21798. PMID: 28001329
Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases.
Cho KJ, Ro JY, Choi J, Choi SH, Nam SY, Kim SY
Eur Arch Otorhinolaryngol 2008 Jul;265 Suppl 1:S47-56. Epub 2007 Oct 13 doi: 10.1007/s00405-007-0488-5. PMID: 17934743
Natural history of HIV-associated salivary gland disease.
Schiødt M, Dodd CL, Greenspan D, Daniels TE, Chernoff D, Hollander H, Wara D, Greenspan JS
Oral Surg Oral Med Oral Pathol 1992 Sep;74(3):326-31. doi: 10.1016/0030-4220(92)90069-3. PMID: 1407995

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