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Malignant cardiac germ cell tumor

MedGen UID:
233143
Concept ID:
C1334566
Neoplastic Process
Synonyms: Malignant Cardiac Germ Cell Neoplasm; malignant Cardiac germ cell neoplasm; Malignant Cardiac Germ Cell Tumor; malignant cardiac germ cell tumor; malignant Cardiac germ cell tumor; malignant Cardiac germ cell tumour; Malignant germ cell neoplasm of heart; Malignant Germ Cell Neoplasm of Heart; malignant germ cell neoplasm of heart; Malignant Germ Cell Neoplasm of the Heart; malignant germ cell neoplasm of the heart; Malignant Germ Cell Tumor of Heart; malignant germ cell tumor of heart; Malignant Germ Cell Tumor of the Heart; malignant germ cell tumor of the heart; malignant germ cell tumour of heart; malignant germ cell tumour of the heart; Malignant Heart Germ Cell Neoplasm; malignant heart germ cell neoplasm; Malignant Heart Germ Cell Tumor; malignant heart germ cell tumor; malignant heart germ cell tumour
SNOMED CT: Malignant germ cell neoplasm of heart (866080006)
 
Monarch Initiative: MONDO:0001991

Definition

A rare malignant germ cell tumor that arises within the myocardium or cardiac chambers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant cardiac germ cell tumor

Professional guidelines

PubMed

Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

Schwartz SM
Clin Chem 2024 Jan 4;70(1):140-149. doi: 10.1093/clinchem/hvad202. PMID: 38175589
Hyeraci M, Papanikolau ES, Grimaldi M, Ricci F, Pallotta S, Monetta R, Minafò YA, Di Lella G, Galdo G, Abeni D, Fania L, Dellambra E
Biomolecules 2023 Jul 2;13(7) doi: 10.3390/biom13071067. PMID: 37509103Free PMC Article
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Diagnosis

Pęczkowska M, Konsek-Komorowska SJ, Kolasińska-Ćwikła AD, Konka M, Michałowska I, Ćwikła JB
Kardiol Pol 2022;80(10):990-1001. Epub 2022 Sep 22 doi: 10.33963/KP.a2022.0222. PMID: 36136036
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Maleszewski JJ, Anavekar NS
Cardiol Clin 2017 Nov;35(4):589-600. Epub 2017 Sep 6 doi: 10.1016/j.ccl.2017.07.011. PMID: 29025549
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128

Therapy

Nazari MA, Hasan R, Haigney M, Maghsoudi A, Lenders JWM, Carey RM, Pacak K
Lancet Diabetes Endocrinol 2023 Dec;11(12):942-954. Epub 2023 Nov 6 doi: 10.1016/S2213-8587(23)00256-5. PMID: 37944546
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145
Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM
Endocr Pract 2008 Dec;14(9):1137-49. doi: 10.4158/EP.14.9.1137. PMID: 19158054

Prognosis

Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145

Clinical prediction guides

Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Recent systematic reviews

Mofatteh M, Mashayekhi MS, Arfaie S, Wei H, Kazerouni A, Skandalakis GP, Pour-Rashidi A, Baiad A, Elkaim L, Lam J, Palmisciano P, Su X, Liao X, Das S, Ashkan K, Cohen-Gadol AA
Neurosurg Rev 2023 Nov 1;46(1):290. doi: 10.1007/s10143-023-02187-x. PMID: 37910275Free PMC Article
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Hamza M, Manasrah N, Patel NN, Sattar Y, Patel B
Am J Cardiol 2023 May 1;194:86-92. Epub 2023 Mar 29 doi: 10.1016/j.amjcard.2023.02.011. PMID: 36996525
Francischini CRD, Mendonça CR, Barcelos KA, Silva MAM, Botelho AFM
Toxicon 2022 Sep;216:15-27. Epub 2022 Jun 27 doi: 10.1016/j.toxicon.2022.06.010. PMID: 35772506
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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