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Malignant cardiac germ cell tumor

MedGen UID:
233143
Concept ID:
C1334566
Neoplastic Process
Synonyms: Malignant Cardiac Germ Cell Neoplasm; malignant Cardiac germ cell neoplasm; Malignant Cardiac Germ Cell Tumor; malignant cardiac germ cell tumor; malignant Cardiac germ cell tumor; malignant Cardiac germ cell tumour; Malignant germ cell neoplasm of heart; Malignant Germ Cell Neoplasm of Heart; malignant germ cell neoplasm of heart; Malignant Germ Cell Neoplasm of the Heart; malignant germ cell neoplasm of the heart; Malignant Germ Cell Tumor of Heart; malignant germ cell tumor of heart; Malignant Germ Cell Tumor of the Heart; malignant germ cell tumor of the heart; malignant germ cell tumour of heart; malignant germ cell tumour of the heart; Malignant Heart Germ Cell Neoplasm; malignant heart germ cell neoplasm; Malignant Heart Germ Cell Tumor; malignant heart germ cell tumor; malignant heart germ cell tumour
SNOMED CT: Malignant germ cell neoplasm of heart (866080006)
 
Monarch Initiative: MONDO:0001991

Definition

A rare malignant germ cell tumor that arises within the myocardium or cardiac chambers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant cardiac germ cell tumor

Professional guidelines

PubMed

Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288

Recent clinical studies

Etiology

Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Chan EY, Ali A, Umana JP, Nguyen DT, Hamilton DJ, Graviss EA, Ravi V, MacGillivray TE, Reardon MJ
J Thorac Cardiovasc Surg 2022 Jul;164(1):158-166.e1. Epub 2020 Oct 3 doi: 10.1016/j.jtcvs.2020.09.100. PMID: 33148444
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Diagnosis

Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Cornu E, Motiejunaite J, Belmihoub I, Vidal-Petiot E, Mirabel M, Amar L
Ann Endocrinol (Paris) 2021 Jun;82(3-4):201-205. Epub 2020 Mar 18 doi: 10.1016/j.ando.2020.03.011. PMID: 32988608
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article

Therapy

Bouffet E, Hansford JR, Garrè ML, Hara J, Plant-Fox A, Aerts I, Locatelli F, van der Lugt J, Papusha L, Sahm F, Tabori U, Cohen KJ, Packer RJ, Witt O, Sandalic L, Bento Pereira da Silva A, Russo M, Hargrave DR
N Engl J Med 2023 Sep 21;389(12):1108-1120. doi: 10.1056/NEJMoa2303815. PMID: 37733309
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145

Prognosis

Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145

Clinical prediction guides

Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Recent systematic reviews

Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Francischini CRD, Mendonça CR, Barcelos KA, Silva MAM, Botelho AFM
Toxicon 2022 Sep;216:15-27. Epub 2022 Jun 27 doi: 10.1016/j.toxicon.2022.06.010. PMID: 35772506
de Waure C, Quaranta G, Gualano MR, Cadeddu C, Jovic-Vranes A, Djikanovic B, La Torre G, Ricciardi W
Public Health 2015 Aug;129(8):1099-113. Epub 2015 Jul 23 doi: 10.1016/j.puhe.2015.06.015. PMID: 26212104
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Zheng J, Zhang J
Clin Neurol Neurosurg 2015 Jan;128:107-11. Epub 2014 Nov 22 doi: 10.1016/j.clineuro.2014.11.010. PMID: 25484302

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