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Malignant Parotid Gland Mixed Tumor

MedGen UID:
233157
•Concept ID:
C1334610
•
Neoplastic Process
Synonyms: Malignant Mixed Neoplasm of Parotid; Malignant Mixed Neoplasm of Parotid Gland; Malignant Mixed Neoplasm of the Parotid; Malignant Mixed Neoplasm of the Parotid Gland; Malignant Mixed Tumor of Parotid; Malignant Mixed Tumor of Parotid Gland; Malignant Mixed Tumor of the Parotid; Malignant Mixed Tumor of the Parotid Gland; Malignant Parotid Gland Mixed Neoplasm; Malignant Parotid Mixed Neoplasm; Malignant Parotid Mixed Tumor

Definition

A malignant tumor arising from the parotid gland. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881
Management of parotid gland neoplasms.
Biörklund A, Eneroth CM
Am J Otolaryngol 1980 Feb;1(2):155-67. doi: 10.1016/s0196-0709(80)80011-1. PMID: 6255810

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Clinicopathological features of incidental parotid lesions.
Al-Balas H, Metwalli ZA, Eberson S, Sada DM
Head Face Med 2021 Mar 23;17(1):10. doi: 10.1186/s13005-021-00262-6. PMID: 33757536Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Parotid gland tumors: a retrospective study of 154 patients.
Maahs GS, Oppermann Pde O, Maahs LG, Machado Filho G, Ronchi AD
Braz J Otorhinolaryngol 2015 May-Jun;81(3):301-6. Epub 2015 Mar 30 doi: 10.1016/j.bjorl.2015.03.007. PMID: 25934418Free PMC Article
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Diagnosis

Clinicopathological features of incidental parotid lesions.
Al-Balas H, Metwalli ZA, Eberson S, Sada DM
Head Face Med 2021 Mar 23;17(1):10. doi: 10.1186/s13005-021-00262-6. PMID: 33757536Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195
Outpatient parotidectomy.
Steckler RM
Am J Surg 1991 Oct;162(4):303-5. doi: 10.1016/0002-9610(91)90136-2. PMID: 1659241
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Salivary gland tumors in children: a retrospective clinical review.
Varan A, Akyüz C, Ataş E, Yücel T, Aydın B, Yalçın B, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2014 Nov;31(8):681-6. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.942936. PMID: 25247345
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
The recurrent pleomorphic adenoma conundrum.
Bradley PJ
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):134-141. doi: 10.1097/MOO.0000000000000435. PMID: 29278551
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Clinical prediction guides

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
An audit of parotid gland surgeries in Kano, Nigeria: A review of 34 cases.
Ajiya A, Shuaibu IY, Omeje UK
Niger Postgrad Med J 2021 Jan-Mar;28(1):27-32. doi: 10.4103/npmj.npmj_309_20. PMID: 33642321
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368

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