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Malignant Parotid Gland Mixed Tumor

MedGen UID:
233157
Concept ID:
C1334610
Neoplastic Process
Synonyms: Malignant Mixed Neoplasm of Parotid; Malignant Mixed Neoplasm of Parotid Gland; Malignant Mixed Neoplasm of the Parotid; Malignant Mixed Neoplasm of the Parotid Gland; Malignant Mixed Tumor of Parotid; Malignant Mixed Tumor of Parotid Gland; Malignant Mixed Tumor of the Parotid; Malignant Mixed Tumor of the Parotid Gland; Malignant Parotid Gland Mixed Neoplasm; Malignant Parotid Mixed Neoplasm; Malignant Parotid Mixed Tumor

Definition

A malignant tumor arising from the parotid gland. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Malard O, Thariat J, Cartier C, Chevalier D, Courtade-Saidi M, Uro-Coste E, Garrel R, Kennel T, Mogultay P, Tronche S, Varoquaux A, Righini CA, Vergez S, Fakhry N
Eur Ann Otorhinolaryngol Head Neck Dis 2021 Jan;138(1):45-49. Epub 2020 Aug 13 doi: 10.1016/j.anorl.2020.08.009. PMID: 32800715
Zaghi S, Hendizadeh L, Hung T, Farahvar S, Abemayor E, Sepahdari AR
Am J Otolaryngol 2014 Nov-Dec;35(6):713-8. Epub 2014 Jul 22 doi: 10.1016/j.amjoto.2014.07.013. PMID: 25128908

Recent clinical studies

Etiology

Dimitrijevic MV, Boricic IV, Tomanović NR, Dimitrijevic AM, Bjelogrlić GM, Krstić AM, Stojkovic GM, Rajovic NZ, Djordjevic IPM, Djurkovic PM
J Craniofac Surg 2022 Jul-Aug 01;33(5):e507-e509. Epub 2022 Feb 2 doi: 10.1097/SCS.0000000000008482. PMID: 36041131
Michel MC, Mulcahy CF, Benito DA, Patel S, Badger C, Kane S, Li NW, Goodman JF, Thakkar PG, Joshi AS
Ann Otol Rhinol Laryngol 2021 Mar;130(3):254-261. Epub 2020 Jul 16 doi: 10.1177/0003489420938101. PMID: 32672069
Aro K, Valle J, Tarkkanen J, Mäkitie A, Atula T
Acta Otorhinolaryngol Ital 2019 Jun;39(3):156-161. doi: 10.14639/0392-100X-2307. PMID: 31131834Free PMC Article
Coniglio AJ, Deal AM, Hackman TG
Head Neck 2019 Jul;41(7):2154-2158. Epub 2019 Feb 1 doi: 10.1002/hed.25671. PMID: 30706566
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Dimitrijevic MV, Boricic IV, Tomanović NR, Dimitrijevic AM, Bjelogrlić GM, Krstić AM, Stojkovic GM, Rajovic NZ, Djordjevic IPM, Djurkovic PM
J Craniofac Surg 2022 Jul-Aug 01;33(5):e507-e509. Epub 2022 Feb 2 doi: 10.1097/SCS.0000000000008482. PMID: 36041131
Haltiner CC, Betz S, Smith J, Nelson B, Ambrosio AA
Mil Med 2021 Jan 25;186(Suppl 1):828-832. doi: 10.1093/milmed/usaa448. PMID: 33499534
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2008 Feb;31(1):95-9. doi: 10.1097/COC.0b013e3181595ae0. PMID: 18376235

Therapy

Ştefănescu EH, Mogoantă CA, Căluianu EI, Predescu OI, Florou C, Chercotă V, Iovănescu G
Rom J Morphol Embryol 2022 Jul-Sep;63(3):563-567. doi: 10.47162/RJME.63.3.11. PMID: 36588495Free PMC Article
Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093Free PMC Article
Woo SH, Kim JP, Baek CH
Head Neck 2016 Mar;38(3):375-9. Epub 2015 May 27 doi: 10.1002/hed.23901. PMID: 25351942
Varan A, Akyüz C, Ataş E, Yücel T, Aydın B, Yalçın B, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2014 Nov;31(8):681-6. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.942936. PMID: 25247345
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Vrinceanu D, Dumitru M, Popa-Cherecheanu M, Marinescu AN, Patrascu OM, Bobirca F
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061167. PMID: 37374372Free PMC Article
Jeong JS, Cho KJ, Kim D, Lee YS, Song JS
Pathol Res Pract 2021 Dec;228:153678. Epub 2021 Oct 29 doi: 10.1016/j.prp.2021.153678. PMID: 34781210
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Di Palma S, Guzzo M
Virchows Arch A Pathol Anat Histopathol 1993;423(5):389-96. doi: 10.1007/BF01607152. PMID: 8116228
Delgado R, Vuitch F, Albores-Saavedra J
Cancer 1993 Sep 1;72(5):1503-12. doi: 10.1002/1097-0142(19930901)72:5<1503::aid-cncr2820720503>3.0.co;2-k. PMID: 7688652

Clinical prediction guides

Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Lombardi D, Tomasoni M, Nicolai A, Paderno A, Grammatica A, Arcuri M, Lancini D, Battocchio S, Ardighieri L, Bozzola A, Pittiani F, Farina D, Redaelli de Zinis LO, Nicolai P, Piazza C
Eur Arch Otorhinolaryngol 2022 May;279(5):2543-2551. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07018-7. PMID: 34355271
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Zhi K, Ren W, Zhou H, Wen Y, Zhang Y
J Oral Maxillofac Surg 2009 Jun;67(6):1239-44. doi: 10.1016/j.joms.2008.09.003. PMID: 19446210

Recent systematic reviews

Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368

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