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Malignant Pericytic Neoplasm

MedGen UID:
233158
Concept ID:
C1334611
Neoplastic Process
Synonyms: Malignant Pericytic Tumor; Malignant Perivascular Neoplasm; Malignant Perivascular Tumor

Definition

A malignant mesenchymal neoplasm arising from the perivascular cells of the connective and soft tissues. It is characterized by the presence of pericytes that grow in a circumferential pattern around vessels, and cytologic atypia. [from NCI]

Professional guidelines

PubMed

Wang K, Mei F, Wu S, Tan Z
Biomed Res Int 2020;2020:2468320. Epub 2020 Nov 2 doi: 10.1155/2020/2468320. PMID: 33204688Free PMC Article
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article
Wong ET, Brem S
J Natl Compr Canc Netw 2008 May;6(5):515-22. doi: 10.6004/jnccn.2008.0039. PMID: 18492463

Recent clinical studies

Etiology

Qian C, Liu C, Liu W, Zhou R, Zhao L
Front Immunol 2023;14:1291530. Epub 2023 Dec 15 doi: 10.3389/fimmu.2023.1291530. PMID: 38193080Free PMC Article
Gust J, Ponce R, Liles WC, Garden GA, Turtle CJ
Front Immunol 2020;11:577027. Epub 2020 Dec 16 doi: 10.3389/fimmu.2020.577027. PMID: 33391257Free PMC Article
Rauschenbach L
Adv Exp Med Biol 2020;1226:97-109. doi: 10.1007/978-3-030-36214-0_8. PMID: 32030679
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Sirohi D, Smith SC, Epstein JI, Balzer BL, Simko JP, Balitzer D, Benhamida J, Kryvenko ON, Gupta NS, Paluru S, da Cunha IW, Leal DN, Williamson SR, de Peralta-Venturina M, Amin MB
Hum Pathol 2017 Jun;64:106-117. Epub 2017 Apr 21 doi: 10.1016/j.humpath.2017.04.005. PMID: 28438616

Diagnosis

Zhang C, Du Z, Gao Y, Lim KS, Zhou W, Huang H, He H, Xiao J, Xu D, Li Q
Cell Metab 2024 Apr 2;36(4):778-792.e10. Epub 2024 Feb 19 doi: 10.1016/j.cmet.2024.01.018. PMID: 38378000
Teh J, Shahabpour M, Drape JL, Feydy A, Sudoł-Szopińska I, Vanhoenacker FM
Semin Musculoskelet Radiol 2021 Apr;25(2):216-231. Epub 2021 Jun 3 doi: 10.1055/s-0041-1724017. PMID: 34082448
Navarro OM
Semin Ultrasound CT MR 2020 Oct;41(5):498-512. Epub 2020 May 28 doi: 10.1053/j.sult.2020.05.014. PMID: 32980096
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Manzat Saplacan RM, Balacescu L, Gherman C, Chira RI, Craiu A, Mircea PA, Lisencu C, Balacescu O
Mediators Inflamm 2017;2017:4708076. Epub 2017 Jan 10 doi: 10.1155/2017/4708076. PMID: 28163397Free PMC Article

Therapy

Xu M, Zhang T, Xia R, Wei Y, Wei X
Mol Cancer 2022 Nov 2;21(1):208. doi: 10.1186/s12943-022-01670-1. PMID: 36324128Free PMC Article
Yamazaki T, Young KH
Mol Carcinog 2022 Feb;61(2):165-172. Epub 2021 Oct 13 doi: 10.1002/mc.23360. PMID: 34644811
Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D
Cancer Immunol Res 2021 Jul;9(7):765-778. Epub 2021 Apr 10 doi: 10.1158/2326-6066.CIR-20-0499. PMID: 33839688Free PMC Article
Belli C, Trapani D, Viale G, D'Amico P, Duso BA, Della Vigna P, Orsi F, Curigliano G
Cancer Treat Rev 2018 Apr;65:22-32. Epub 2018 Feb 22 doi: 10.1016/j.ctrv.2018.02.004. PMID: 29502037
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article

Prognosis

Du Y, Shi J, Wang J, Xun Z, Yu Z, Sun H, Bao R, Zheng J, Li Z, Ye Y
Cancer Res 2024 Jan 16;84(2):192-210. doi: 10.1158/0008-5472.CAN-23-1418. PMID: 38225927
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
Li Y, Li X, Chen H, Sun K, Li H, Zhou Y, Wang J, Bai F, Yang F
Clin Transl Med 2022 Feb;12(2):e723. doi: 10.1002/ctm2.723. PMID: 35184398Free PMC Article
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL
Nat Commun 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. PMID: 34921143Free PMC Article
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article

Clinical prediction guides

Petrik J, Lauks S, Garlisi B, Lawler J
Semin Cell Dev Biol 2024 Mar 1;155(Pt B):3-11. Epub 2023 Jun 5 doi: 10.1016/j.semcdb.2023.05.010. PMID: 37286406
Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, Coppieters W, van den Bosch TPP, Bolleboom A, Gao Z, Vincent AJPE, Karim L, Deckers M, Taphoorn MJB, Kerkhof M, Weyerbrock A, Sanson M, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Golfinopoulos V, Bours V, van den Bent MJ, Robe PA, French PJ
Cancer Cell 2023 Apr 10;41(4):678-692.e7. Epub 2023 Mar 9 doi: 10.1016/j.ccell.2023.02.019. PMID: 36898379
Iwamura R, Komatsu K, Kusano M, Kubo C, Inaba Y, Shiba E, Nawata A, Tajiri R, Matsuyama A, Matoba H, Koga K, Takeda M, Itami H, Hisaoka M
Mod Pathol 2023 Mar;36(3):100070. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100070. PMID: 36788105
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL
Nat Commun 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. PMID: 34921143Free PMC Article
Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

Recent systematic reviews

Valle IB, Schuch LF, da Silva JM, Gala-García A, Diniz IMA, Birbrair A, Abreu LG, Silva TA
Head Neck Pathol 2020 Dec;14(4):1080-1091. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01188-2. PMID: 32506378Free PMC Article

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