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Malignant Pericytic Neoplasm

MedGen UID:
233158
•Concept ID:
C1334611
•
Neoplastic Process
Synonyms: Malignant Pericytic Tumor; Malignant Perivascular Neoplasm; Malignant Perivascular Tumor

Definition

A malignant mesenchymal neoplasm arising from the perivascular cells of the connective and soft tissues. It is characterized by the presence of pericytes that grow in a circumferential pattern around vessels, and cytologic atypia. [from NCI]

Professional guidelines

PubMed

Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database.
Wang K, Mei F, Wu S, Tan Z
Biomed Res Int 2020;2020:2468320. Epub 2020 Nov 2 doi: 10.1155/2020/2468320. PMID: 33204688Free PMC Article
PDGF receptors in tumor stroma: Biological effects and associations with prognosis and response to treatment.
Östman A
Adv Drug Deliv Rev 2017 Nov 1;121:117-123. Epub 2017 Sep 29 doi: 10.1016/j.addr.2017.09.022. PMID: 28970051
Normalization of the vasculature for treatment of cancer and other diseases.
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article

Recent clinical studies

Etiology

Fusion genes aiding the diagnosis of soft tissue tumours of the oral cavity: From bench to bedside.
Gomes IP, Guimarães LM, Gomez RS, Gomes CC
J Oral Pathol Med 2023 Aug;52(7):575-582. Epub 2023 Apr 17 doi: 10.1111/jop.13429. PMID: 36945188
Cytokines in CAR T Cell-Associated Neurotoxicity.
Gust J, Ponce R, Liles WC, Garden GA, Turtle CJ
Front Immunol 2020;11:577027. Epub 2020 Dec 16 doi: 10.3389/fimmu.2020.577027. PMID: 33391257Free PMC Article
Spinal Cord Tumor Microenvironment.
Rauschenbach L
Adv Exp Med Biol 2020;1226:97-109. doi: 10.1007/978-3-030-36214-0_8. PMID: 32030679
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Pericytes, an overlooked player in vascular pathobiology.
Ferland-McCollough D, Slater S, Richard J, Reni C, Mangialardi G
Pharmacol Ther 2017 Mar;171:30-42. Epub 2016 Dec 1 doi: 10.1016/j.pharmthera.2016.11.008. PMID: 27916653Free PMC Article

Diagnosis

Hand Masses.
Teh J, Shahabpour M, Drape JL, Feydy A, Sudoł-Szopińska I, Vanhoenacker FM
Semin Musculoskelet Radiol 2021 Apr;25(2):216-231. Epub 2021 Jun 3 doi: 10.1055/s-0041-1724017. PMID: 34082448
Pearls and Pitfalls in the Imaging of Soft-Tissue Masses in Children.
Navarro OM
Semin Ultrasound CT MR 2020 Oct;41(5):498-512. Epub 2020 May 28 doi: 10.1053/j.sult.2020.05.014. PMID: 32980096
What is new in pericytomatous, myoid, and myofibroblastic tumors?
John I, Fritchie KJ
Virchows Arch 2020 Jan;476(1):57-64. Epub 2019 Nov 8 doi: 10.1007/s00428-019-02700-y. PMID: 31705190
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
The Role of PDGFs and PDGFRs in Colorectal Cancer.
Manzat Saplacan RM, Balacescu L, Gherman C, Chira RI, Craiu A, Mircea PA, Lisencu C, Balacescu O
Mediators Inflamm 2017;2017:4708076. Epub 2017 Jan 10 doi: 10.1155/2017/4708076. PMID: 28163397Free PMC Article

Therapy

The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.
Iesato A, Li S, Sadow PM, Abbasian M, Nazarian A, Lawler J, Nucera C
Thyroid 2023 Jul;33(7):835-848. doi: 10.1089/thy.2022.0597. PMID: 37171127Free PMC Article
Targeting the tumor stroma for cancer therapy.
Xu M, Zhang T, Xia R, Wei Y, Wei X
Mol Cancer 2022 Nov 2;21(1):208. doi: 10.1186/s12943-022-01670-1. PMID: 36324128Free PMC Article
Exercise Training Improves Tumor Control by Increasing CD8(+) T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.
Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D
Cancer Immunol Res 2021 Jul;9(7):765-778. Epub 2021 Apr 10 doi: 10.1158/2326-6066.CIR-20-0499. PMID: 33839688Free PMC Article
Targeting the microenvironment in solid tumors.
Belli C, Trapani D, Viale G, D'Amico P, Duso BA, Della Vigna P, Orsi F, Curigliano G
Cancer Treat Rev 2018 Apr;65:22-32. Epub 2018 Feb 22 doi: 10.1016/j.ctrv.2018.02.004. PMID: 29502037
Normalization of the vasculature for treatment of cancer and other diseases.
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article

Prognosis

Integration of Pan-Cancer Single-Cell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment.
Du Y, Shi J, Wang J, Xun Z, Yu Z, Sun H, Bao R, Zheng J, Li Z, Ye Y
Cancer Res 2024 Jan 16;84(2):192-210. doi: 10.1158/0008-5472.CAN-23-1418. PMID: 38225927
The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
Single-cell RNA sequencing reveals the multi-cellular ecosystem in different radiological components of pulmonary part-solid nodules.
Li Y, Li X, Chen H, Sun K, Li H, Zhou Y, Wang J, Bai F, Yang F
Clin Transl Med 2022 Feb;12(2):e723. doi: 10.1002/ctm2.723. PMID: 35184398Free PMC Article
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL
Nat Commun 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. PMID: 34921143Free PMC Article
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming.
Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH
Nature 2017 Apr 13;544(7649):250-254. Epub 2017 Apr 3 doi: 10.1038/nature21724. PMID: 28371798Free PMC Article

Clinical prediction guides

Thrombospondins in the tumor microenvironment.
Petrik J, Lauks S, Garlisi B, Lawler J
Semin Cell Dev Biol 2024 Mar 1;155(Pt B):3-11. Epub 2023 Jun 5 doi: 10.1016/j.semcdb.2023.05.010. PMID: 37286406
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma.
Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, Coppieters W, van den Bosch TPP, Bolleboom A, Gao Z, Vincent AJPE, Karim L, Deckers M, Taphoorn MJB, Kerkhof M, Weyerbrock A, Sanson M, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Golfinopoulos V, Bours V, van den Bent MJ, Robe PA, French PJ
Cancer Cell 2023 Apr 10;41(4):678-692.e7. Epub 2023 Mar 9 doi: 10.1016/j.ccell.2023.02.019. PMID: 36898379
PDGFRB and NOTCH3 Mutations are Detectable in a Wider Range of Pericytic Tumors, Including Myopericytomas, Angioleiomyomas, Glomus Tumors, and Their Combined Tumors.
Iwamura R, Komatsu K, Kusano M, Kubo C, Inaba Y, Shiba E, Nawata A, Tajiri R, Matsuyama A, Matoba H, Koga K, Takeda M, Itami H, Hisaoka M
Mod Pathol 2023 Mar;36(3):100070. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100070. PMID: 36788105
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL
Nat Commun 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. PMID: 34921143Free PMC Article
Cutaneous myofibroma.
Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

Recent systematic reviews

Pericyte in Oral Squamous Cell Carcinoma: A Systematic Review.
Valle IB, Schuch LF, da Silva JM, Gala-García A, Diniz IMA, Birbrair A, Abreu LG, Silva TA
Head Neck Pathol 2020 Dec;14(4):1080-1091. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01188-2. PMID: 32506378Free PMC Article

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