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Mediastinal Mixed Embryonal Carcinoma and Teratoma

MedGen UID:
233172
•Concept ID:
C1334670
•
Neoplastic Process
Synonyms: Mediastinal Teratocarcinoma; Mixed Embryonal Carcinoma and Teratoma of Mediastinum; Mixed Embryonal Carcinoma and Teratoma of the Mediastinum; Teratocarcinoma of Mediastinum; Teratocarcinoma of the Mediastinum

Definition

An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum and contains teratoma and embryonal carcinoma components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Mixed Embryonal Carcinoma and Teratoma

Professional guidelines

PubMed

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations.
McKenney JK, Heerema-McKenney A, Rouse RV
Adv Anat Pathol 2007 Mar;14(2):69-92. doi: 10.1097/PAP.0b013e31803240e6. PMID: 17471115

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Mediastinal germ cell tumors in childhood.
Yalçın B, Demir HA, Tanyel FC, Akçören Z, Varan A, Akyüz C, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2012 Oct;29(7):633-42. Epub 2012 Aug 9 doi: 10.3109/08880018.2012.713084. PMID: 22877235
Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations.
McKenney JK, Heerema-McKenney A, Rouse RV
Adv Anat Pathol 2007 Mar;14(2):69-92. doi: 10.1097/PAP.0b013e31803240e6. PMID: 17471115
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

Diagnosis

Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features.
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Clinicopathological spectrum of teratomas: An 8-year retrospective study from a tertiary care institute.
Varma AV, Malpani G, Agrawal P, Malukani K, Dosi S
Indian J Cancer 2017 Jul-Sep;54(3):576-579. doi: 10.4103/ijc.IJC_294_17. PMID: 29798962
Mediastinal germ cell tumors in childhood.
Yalçın B, Demir HA, Tanyel FC, Akçören Z, Varan A, Akyüz C, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2012 Oct;29(7):633-42. Epub 2012 Aug 9 doi: 10.3109/08880018.2012.713084. PMID: 22877235
Fat-containing lesions of the chest.
Gaerte SC, Meyer CA, Winer-Muram HT, Tarver RD, Conces DJ Jr
Radiographics 2002 Oct;22 Spec No:S61-78. doi: 10.1148/radiographics.22.suppl_1.g02oc08s61. PMID: 12376601
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

Therapy

Successful treatment of radiotherapy and apatinib in patient with mediastinal mixed non-seminomatous germ cell tumor: A case report.
Ren C, Zhao J, Kang L, Di Y, Qiu G, Wang Q
Medicine (Baltimore) 2021 Oct 29;100(43):e27617. doi: 10.1097/MD.0000000000027617. PMID: 34713845Free PMC Article
Late relapse in testicular germ cell tumors.
Detti B, Livi L, Scoccianti S, Meattini I, Gacci M, Lapini A, Biti G
Tumori 2007 Sep-Oct;93(5):428-31. doi: 10.1177/030089160709300504. PMID: 18038873
Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study.
Mardiak J, Sálek T, Sycová-Milá Z, Obertová J, Recková M, Mego M, Hlavatá Z, Brozmanová K, Risnyovzská Z, Svetlovská D, Koza I
Neoplasma 2007;54(3):240-5. PMID: 17447857
A xenograft line of human teratocarcinoma established by serial transplantation in severe combined immunodeficient (SCID) mice.
Abe Y, Oshika Y, Ohnishi Y, Suto R, Tokunaga T, Yamazaki H, Kijima H, Hiraoka N, Ueyama Y, Tamaoki N, Nakamura M
APMIS 1997 Apr;105(4):283-9. doi: 10.1111/j.1699-0463.1997.tb00570.x. PMID: 9164470
Late relapse of germ cell tumors after cisplatin-based chemotherapy.
Gerl A, Clemm C, Schmeller N, Hentrich M, Lamerz R, Wilmanns W
Ann Oncol 1997 Jan;8(1):41-7. doi: 10.1023/a:1008253323854. PMID: 9093706

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Clinicopathological spectrum of teratomas: An 8-year retrospective study from a tertiary care institute.
Varma AV, Malpani G, Agrawal P, Malukani K, Dosi S
Indian J Cancer 2017 Jul-Sep;54(3):576-579. doi: 10.4103/ijc.IJC_294_17. PMID: 29798962
Mediastinal germ cell tumors in childhood.
Yalçın B, Demir HA, Tanyel FC, Akçören Z, Varan A, Akyüz C, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2012 Oct;29(7):633-42. Epub 2012 Aug 9 doi: 10.3109/08880018.2012.713084. PMID: 22877235
Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma.
Moran CA, Travis WD, Carter D, Koss MN
Arch Pathol Lab Med 1993 Jun;117(6):641-4. PMID: 8135909

Clinical prediction guides

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations.
McKenney JK, Heerema-McKenney A, Rouse RV
Adv Anat Pathol 2007 Mar;14(2):69-92. doi: 10.1097/PAP.0b013e31803240e6. PMID: 17471115
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

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