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Mediastinal yolk sac tumor

MedGen UID:
233176
Concept ID:
C1334683
Neoplastic Process
Synonyms: Endodermal Sinus Neoplasm of Mediastinum; endodermal sinus neoplasm of mediastinum; Endodermal Sinus Neoplasm of the Mediastinum; endodermal sinus neoplasm of the mediastinum; Endodermal Sinus Tumor of Mediastinum; endodermal sinus tumor of mediastinum; Endodermal Sinus Tumor of the Mediastinum; endodermal sinus tumor of the mediastinum; endodermal sinus tumour of mediastinum; endodermal sinus tumour of the mediastinum; EST; Mediastinal Endodermal Sinus Neoplasm; mediastinal endodermal sinus neoplasm; Mediastinal Endodermal Sinus Tumor; mediastinal endodermal sinus tumor; mediastinal endodermal sinus tumors; mediastinal endodermal sinus tumour; mediastinal endodermal sinus tumours; Mediastinal Yolk Sac Neoplasm; mediastinal yolk Sac neoplasm; Mediastinal Yolk Sac Tumor; mediastinal yolk sac tumor; mediastinal yolk Sac tumor; mediastinal yolk Sac tumour; mediastinum yolk sac tumor; mediastinum yolk sac tumour; Yolk Sac Neoplasm of Mediastinum; yolk Sac neoplasm of mediastinum; Yolk Sac Neoplasm of the Mediastinum; yolk Sac neoplasm of the mediastinum; Yolk Sac Tumor of Mediastinum; yolk Sac tumor of mediastinum; Yolk Sac Tumor of the Mediastinum; yolk Sac tumor of the mediastinum; yolk Sac tumour of mediastinum; yolk Sac tumour of the mediastinum
 
Monarch Initiative: MONDO:0023726

Definition

An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Porcu P, Bhatia S, Sharma M, Einhorn LH
J Clin Oncol 2000 Mar;18(6):1181-6. doi: 10.1200/JCO.2000.18.6.1181. PMID: 10715286

Recent clinical studies

Etiology

Yang Q, Liu H, Liu Y
Echocardiography 2021 Sep;38(9):1662-1665. Epub 2021 Aug 25 doi: 10.1111/echo.15180. PMID: 34435391
Levy DR, Agaram NP, Kao CS, Franks SE, Kesler KA, Stram AR, Einhorn LH, Bangs CD, Ulbright TM
Am J Surg Pathol 2021 Apr 1;45(4):463-476. doi: 10.1097/PAS.0000000000001615. PMID: 33136584
Porcu P, Bhatia S, Sharma M, Einhorn LH
J Clin Oncol 2000 Mar;18(6):1181-6. doi: 10.1200/JCO.2000.18.6.1181. PMID: 10715286

Diagnosis

Yang Q, Liu H, Liu Y
Echocardiography 2021 Sep;38(9):1662-1665. Epub 2021 Aug 25 doi: 10.1111/echo.15180. PMID: 34435391
Imaniar R, Syahruddin E, Soepandi PZ, Putra AC, Nurwidya F
Exp Oncol 2018 Mar;40(1):82-84. PMID: 29600980
Silva LLCD, Vergilio FS, Yamaguti DCC, Cruz IAND, Queen JAG
Einstein (Sao Paulo) 2017 Oct-Dec;15(4):496-499. Epub 2017 Sep 21 doi: 10.1590/S1679-45082017RC4008. PMID: 28954036Free PMC Article
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Saxman S, Nichols CR, Williams SD, Loehrer PJ, Einhorn LH
J Thorac Cardiovasc Surg 1991 Dec;102(6):913-6. PMID: 1960997

Therapy

Liu B, Lin G, Liu J, Liu H, Shang X, Li J
Thorac Cancer 2018 Apr;9(4):491-494. Epub 2018 Jan 10 doi: 10.1111/1759-7714.12591. PMID: 29318787Free PMC Article
Hirakawa H, Nakashima C, Nakamura T, Masuda M, Funakoshi T, Nakagawa S, Horimatsu T, Matsubara K, Muto M, Kimura S, Sueoka-Aragane N
J Med Case Rep 2017 Feb 16;11(1):43. doi: 10.1186/s13256-017-1213-7. PMID: 28202048Free PMC Article
Porcu P, Bhatia S, Sharma M, Einhorn LH
J Clin Oncol 2000 Mar;18(6):1181-6. doi: 10.1200/JCO.2000.18.6.1181. PMID: 10715286
Uchiyama M, Iwafuchi M, Matsuda Y, Naitoh M, Yagi M, Yamato Y
J Pediatr Surg 1996 Sep;31(9):1318-21. doi: 10.1016/s0022-3468(96)90264-x. PMID: 8887115
Saxman S, Nichols CR, Williams SD, Loehrer PJ, Einhorn LH
J Thorac Cardiovasc Surg 1991 Dec;102(6):913-6. PMID: 1960997

Prognosis

Imaniar R, Syahruddin E, Soepandi PZ, Putra AC, Nurwidya F
Exp Oncol 2018 Mar;40(1):82-84. PMID: 29600980
Liu B, Lin G, Liu J, Liu H, Shang X, Li J
Thorac Cancer 2018 Apr;9(4):491-494. Epub 2018 Jan 10 doi: 10.1111/1759-7714.12591. PMID: 29318787Free PMC Article
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Porcu P, Bhatia S, Sharma M, Einhorn LH
J Clin Oncol 2000 Mar;18(6):1181-6. doi: 10.1200/JCO.2000.18.6.1181. PMID: 10715286
Saxman S, Nichols CR, Williams SD, Loehrer PJ, Einhorn LH
J Thorac Cardiovasc Surg 1991 Dec;102(6):913-6. PMID: 1960997

Clinical prediction guides

Cheng X, Yu H, Li J, Han X, Meng E, Zhou H, Wang D, Niu B, Zhang X
Cancer Biol Ther 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635. PMID: 35576916Free PMC Article
Hirakawa H, Nakashima C, Nakamura T, Masuda M, Funakoshi T, Nakagawa S, Horimatsu T, Matsubara K, Muto M, Kimura S, Sueoka-Aragane N
J Med Case Rep 2017 Feb 16;11(1):43. doi: 10.1186/s13256-017-1213-7. PMID: 28202048Free PMC Article
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Coskun U, Günel N, Yildirim Y, Memis L, Boyacioglu ZM
Med Princ Pract 2002 Oct-Dec;11(4):218-20. doi: 10.1159/000065812. PMID: 12424419
Porcu P, Bhatia S, Sharma M, Einhorn LH
J Clin Oncol 2000 Mar;18(6):1181-6. doi: 10.1200/JCO.2000.18.6.1181. PMID: 10715286

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